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View article: First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT
First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT Open
Purpose The physical properties of 44 Sc, combined with its imminent clinical application, position it as a prime candidate for in vivo positronium lifetime imaging. In this study, we investigate the count statistics for ortho-positronium …
View article: Quality control of plastic scintillators for the total-body J-PET scanner
Quality control of plastic scintillators for the total-body J-PET scanner Open
The construction of the total-body Jagiellonian positron emission tomography scanner requires component verification before detector assembly. The purpose of this research is to verify the quality of BC-408 plastic scintillators with dimen…
View article: Positronium Imaging: History, Current Status, and Future Perspectives
Positronium Imaging: History, Current Status, and Future Perspectives Open
Positronium imaging was recently proposed to image the properties of positronium atoms in the patient body. Positronium properties depend on the size of intramolecular voids and oxygen concentration; therefore, they deliver information dif…
View article: Developing a Tumor Microenvironment in Rotating Human Melanoma Cell Cultures: Study of a Novel Preclinical Model
Developing a Tumor Microenvironment in Rotating Human Melanoma Cell Cultures: Study of a Novel Preclinical Model Open
The 3D culture is currently the most promising technique used in preclinical studies for drug testing. One of the main challenges in preclinical in vitro studies is the long-term observations (over 21 days), which can be performed using ce…
View article: First Positronium Lifetime Imaging with Scandium-44 on a Long Axial Field-of-view PET/CT
First Positronium Lifetime Imaging with Scandium-44 on a Long Axial Field-of-view PET/CT Open
Purpose: 44Sc has been successfully produced, synthesized, labeled and first-in-human studies were conducted some years ago. The decay properties of 44Sc, together with being close to a clinical implementation, make it an ideal candidate f…
View article: Epigenetic Biomarkers of Cardiovascular Risk in Frail Patients—A Scope Review
Epigenetic Biomarkers of Cardiovascular Risk in Frail Patients—A Scope Review Open
Epigenetic biomarkers offer promising potential for early identification and risk stratification of frail individuals susceptible to adverse cardiovascular outcomes. This scope review aimed to identify and evaluate epigenetic biomarkers co…
View article: μPPET: Investigating the Muon Puzzle with J-PET Detectors
μPPET: Investigating the Muon Puzzle with J-PET Detectors Open
The μPPET [mu(μ)on Probe with J-PET] project aims to investigate the “Muon Puzzle” seen in cosmic ray air showers. This puzzle arises from the observation of a significantly larger number of muons on Earth’s surface than that predicted by …
View article: In Vivo Intralesional Positronium Lifetime Imaging of Thyroid Cancer Using Clinically Routine I-124 PET/CT
In Vivo Intralesional Positronium Lifetime Imaging of Thyroid Cancer Using Clinically Routine I-124 PET/CT Open
Purpose Measuring the lifetime of orthopositronium (oPs), the spin triplet of an electron and positron, has emerged as a promising approach for assessing tumor microen-vironment characteristics, leveraging the susceptibility of oPs lifetim…
View article: Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a plastic PET scanner
Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a plastic PET scanner Open
In state-of-the-art positron emission tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via t…
View article: The Proteomic Analysis of Platelet Extracellular Vesicles in Diabetic Patients by nanoLC-MALDI-MS/MS and nanoLC-TIMS-MS/MS
The Proteomic Analysis of Platelet Extracellular Vesicles in Diabetic Patients by nanoLC-MALDI-MS/MS and nanoLC-TIMS-MS/MS Open
Platelet extracellular vesicles (PEVs) are emerging as key biomarkers in diabetes mellitus (DM), reflecting altered platelet function and coagulation pathways. This study compares two proteomic techniques—nanoLC-MALDI-MS/MS and nanoLC-TIMS…
View article: Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes
Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes Open
Melanoma is an aggressive disease that arises from mutations in the cells that produce the pigment melanin, melanocytes. Melanoma is characterized by a high mortality rate, due to avoidance of applied therapies and metastasis to other orga…
View article: Realistic total‐body J‐PET geometry optimization: Monte Carlo study
Realistic total‐body J‐PET geometry optimization: Monte Carlo study Open
Background Total‐body (TB) Positron Emission Tomography (PET) is one of the most promising medical diagnostics modalities, opening new perspectives for personalized medicine, low‐dose imaging, multi‐organ dynamic imaging or kinetic modelin…
View article: Positronium Lifetime Imaging with the Biograph Vision Quadra using 124I
Positronium Lifetime Imaging with the Biograph Vision Quadra using 124I Open
Purpose: Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom mea…
View article: Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes
Effect of Neutron Radiation on 10BPA-Loaded Melanoma Spheroids and Melanocytes Open
Melanoma is an aggressive disease that arises from mutations in the cells that produce the pigment melanin, melanocytes. Melanoma is characterized by a high mortality rate, due to avoidance of applied therapies and metastasis to other orga…
View article: First Positronium Imaging Using <sup>44</sup>Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom
First Positronium Imaging Using <sup>44</sup>Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom Open
Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the p…
View article: Calibration of PALS System withCRM Materials for BiomedicalStudies
Calibration of PALS System withCRM Materials for BiomedicalStudies Open
Objective and method: Positron annihilation lifetime spectroscopy (PALS) is a powerfultechnique in material science that allows the investigation of the properties andbehavior of positrons in various materials. PALS can be used to investig…
View article: Extracellular vesicles produced in hollow fiber bioreactor as potential drug delivery systems – cell uptake tracking with label-free optical diffraction tomography
Extracellular vesicles produced in hollow fiber bioreactor as potential drug delivery systems – cell uptake tracking with label-free optical diffraction tomography Open
Extracellular vesicles (EVs) are emerging as one of the most promising candidates for novel drug delivery systems (DDS). Unique features, like biocompatibility, encapsulation capability and functionalization for precise targeting make them…
View article: Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study
Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study Open
Introduction: Melanoma, an aggressive and highly immunogenic cancer, arises from uncontrolled melanocyte growth. FLASH radiotherapy, a breakthrough technique, delivers ultra-high radiation doses, offering the potential for improved cancer …
View article: Calculational Cross-Sections of (p,x) Reactions on the <sup>12</sup>C, <sup>14</sup>N and <sup>16</sup>O for <sup>10,11</sup>C Production
Calculational Cross-Sections of (p,x) Reactions on the <sup>12</sup>C, <sup>14</sup>N and <sup>16</sup>O for <sup>10,11</sup>C Production Open
For in vivo dose delivery monitoring in proton therapy the positron emission tomography can be applied because the positron emitters are being produced by the nuclear reactions of protons with atomic nuclei in a human body. The estimation …
View article: In Vivo Positronium Lifetime Measurements with Intravenous Tracer Administration and a Long Axial Field-of-View PET/CT
In Vivo Positronium Lifetime Measurements with Intravenous Tracer Administration and a Long Axial Field-of-View PET/CT Open
Purpose Measuring orthopositronium (oPs) lifetime could in principle provide diagnostic information about the tissue microenvironment that goes beyond standard positron emission tomography (PET) imaging. This study demonstrates that in viv…
View article: Development of the normalization method for the first large field-of-view plastic-based PET Modular scanner
Development of the normalization method for the first large field-of-view plastic-based PET Modular scanner Open
In positron emission tomography acquisition (PET), sensitivity along a line of response can vary due to crystal geometrical arrangements in the scanner and/or detector inefficiencies, leading to severe artefacts in the reconstructed image.…
View article: Positronium image of the human brain in vivo
Positronium image of the human brain in vivo Open
Positronium is abundantly produced within the molecular voids of a patient’s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxyg…
View article: Nanoporosity imaging by positronium lifetime tomography
Nanoporosity imaging by positronium lifetime tomography Open
Positron Annihilation Lifetime Spectroscopy (PALS) is a well-established non-destructive technique used for nanostructural characterization of porous materials. It is based on the annihilation of a positron and an electron. Mean positron l…
View article: Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner
Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner Open
Overall, the methodology presented in this manuscript demonstrates the repeatability of Ps lifetime measurements with clinically available isotopes in a commercially-available LA-FOV PET scanner. This validation work lays the foundation fo…
View article: Developing tumor microenvironment in rotating human melanoma cell cultures: study of novel preclinical model
Developing tumor microenvironment in rotating human melanoma cell cultures: study of novel preclinical model Open
More than 97% of anticancer drugs under investigation fail in vitro evaluation, while only 0.4% of drug candidates that pass this stage proceed to the clinical trials. The differences between cell morphology and physiology observed in vitr…
View article: Investigation of Novel Preclinical Total Body PET Designed With J-PET Technology:A Simulation Study
Investigation of Novel Preclinical Total Body PET Designed With J-PET Technology:A Simulation Study Open
The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment …