Ewan M. Smith
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mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 Open
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the adjacent 5′TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex on these transcripts. mTORC1 controls TOP mRNA translation via LARP…
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction Open
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achi…
LARP1 is a major phosphorylation substrate of mTORC1 Open
The mammalian target of rapamycin complex 1 (mTORC1) controls critical cellular functions such as protein synthesis, lipid metabolism, protein turnover and ribosome biogenesis through the phosphorylation of multiple substrates. In this stu…
Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells Open
Two proteins comprising the ZEB family of zinc finger transcription factors, ZEB1 and ZEB2, execute EMT programs in embryonic development and cancer. By studying regulation of their expression, we describe a novel mechanism that limits ZEB…
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice Open
See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis rates in cells. …