Eyad Almasri
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View article: Clinical Laboratory Experience With Prenatal cfDNA Screening in Triplet Pregnancies
Clinical Laboratory Experience With Prenatal cfDNA Screening in Triplet Pregnancies Open
Objective Prenatal cfDNA screening is the most sensitive and specific screen for common aneuploidies in singleton and twin pregnancies and has been endorsed by several professional societies as a first‐tier screen or contingent screen. How…
View article: 0912 Obstructive Sleep Apnea and Periodic Limb Movements of Sleep in Patients with Chronic Obstructive Pulmonary Disease
0912 Obstructive Sleep Apnea and Periodic Limb Movements of Sleep in Patients with Chronic Obstructive Pulmonary Disease Open
Introduction Chronic obstructive pulmonary disease (COPD) coexisting with obstructive sleep apnea, the overlap syndrome, can worsen nocturnal hypoxemia, disrupted sleep architecture, and adverse consequences. OSA is often comorbid with ele…
View article: Overview of the Current Challenges in Pulmonary Coccidioidomycosis
Overview of the Current Challenges in Pulmonary Coccidioidomycosis Open
Coccidioidomycosis is a disease caused by soil fungi of the genus Coccidioides, divided genetically into Coccidioides immitis (California isolates) and Coccidioides posadasii (isolates outside California). Coccidioidomycosis is transmitted…
View article: Impact of Baseline SARS-CoV-2 Load in Plasma and Upper Airways on the Incidence of Acute Extrapulmonary Complications of COVID-19: A Multicentric, Prospective, Cohort Study
Impact of Baseline SARS-CoV-2 Load in Plasma and Upper Airways on the Incidence of Acute Extrapulmonary Complications of COVID-19: A Multicentric, Prospective, Cohort Study Open
Background Extrapulmonary complications (EPCs) are common in patients hospitalized for coronavirus disease 2019 (COVID-19), but data on their clinical consequences and association with viral replication and systemic viral dissemination are…
View article: Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Open
Importance Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates. Objective To determine whether aceta…
View article: Stress cardiomyopathy as a cardiovascular manifestation of COVID-19
Stress cardiomyopathy as a cardiovascular manifestation of COVID-19 Open
Patients with coronavirus disease 2019 (COVID-19) may present with a broad spectrum of clinical manifestations, affecting several organ systems. Commonly reported cardiac manifestations include myocardial injury, heart failure (HF), cardio…
View article: Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial Open
View article: Laboratory performance of genome-wide cfDNA for copy number variants as compared to prenatal microarray
Laboratory performance of genome-wide cfDNA for copy number variants as compared to prenatal microarray Open
View article: Positive cfDNA screening results for 22q11.2 deletion syndrome—Clinical and laboratory considerations
Positive cfDNA screening results for 22q11.2 deletion syndrome—Clinical and laboratory considerations Open
Introduction: Non-invasive prenatal screening (NIPS) via cell-free DNA (cfDNA) screens for fetal chromosome disorders using maternal plasma, including 22q11.2 deletion syndrome (22q11.2DS). While it is the commonest microdeletion syndrome …
View article: Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months
Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months Open
Importance Individuals who survived COVID-19 often report persistent symptoms, disabilities, and financial consequences. However, national longitudinal estimates of symptom burden remain limited. Objective To measure the incidence and chan…
View article: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 Open
National Institutes of Health.
View article: Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial
Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial Open
View article: Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial Open
View article: Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO):a randomised controlled trial
Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO):a randomised controlled trial Open
BackgroundWe aimed to assess the efficacy and safety of two neutralising monoclonal antibody therapies (sotrovimab [Vir Biotechnology and GlaxoSmithKline] and BRII-196 plus BRII-198 [Brii Biosciences]) for adults admitted to hospital for C…
View article: Tixagevimab/Cilgavimab for Treatment of Hospitalised COVID-19 Patients: A Randomised, Double-Blind, Phase 3 Trial
Tixagevimab/Cilgavimab for Treatment of Hospitalised COVID-19 Patients: A Randomised, Double-Blind, Phase 3 Trial Open
View article: Assessing CAR T-Cell Therapy Response Using Genome-Wide Sequencing of Cell-Free DNA in Patients With B-Cell Lymphomas
Assessing CAR T-Cell Therapy Response Using Genome-Wide Sequencing of Cell-Free DNA in Patients With B-Cell Lymphomas Open
Methods that enable monitoring of therapeutic efficacy of autologous chimeric antigen receptor (CAR) T-cell therapy will be clinically useful. The aim of this study is to demonstrate the feasibility of blood-derived cell-free DNA (cfDNA) t…
View article: Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible
Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible Open
When tissue biopsy is not medically prudent or tissue is insufficient for molecular testing, alternative methods are needed. Because cell-free DNA (cfDNA) has been shown to provide a representative surrogate for tumor tissue, we sought to …
View article: Genome-wide cell-free DNA screening: a focus on copy-number variants
Genome-wide cell-free DNA screening: a focus on copy-number variants Open
Genome-wide cfDNA screening identifies chromosomal abnormalities beyond the scope of traditional cfDNA screening, and the overall PPV associated with subchromosomal CNVs in cases with diagnostic outcomes was >70%.
View article: Correction to: Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy number variants
Correction to: Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy number variants Open
View article: Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy-number variants
Three years of clinical experience with a genome-wide cfDNA screening test for aneuploidies and copy-number variants Open
A broader patient population is utilizing genome-wide cfDNA, yet positivity rates and the contribution of genome-wide events have remained stable at approximately 5% and 25%, respectively. Test performance in a real-world clinical populati…
View article: Application of mosaicism ratio to multifetal gestations
Application of mosaicism ratio to multifetal gestations Open
Mosaicism ratio, or MR, is a laboratory metric that can be calculated using massively parallel sequencing data from cell-free DNA (cfDNA) screening. MR compares the amount of cfDNA present from a particular chromosome or chromosomal region…
View article: Not all low fetal fraction cell‐free DNA screening failures are at increased risk for aneuploidy
Not all low fetal fraction cell‐free DNA screening failures are at increased risk for aneuploidy Open
Objective To evaluate cell‐free DNA (cfDNA) redraws and pregnancy outcomes following low fetal fraction (FF) cfDNA failures, as it has been suggested that a failed cfDNA screen due to insufficient FF carries increased risk for fetal aneupl…
View article: Issue Information
Issue Information Open
8Effi cacy, safety, and success of 18-versus 20-gauge needle for transabdominal chorionic
View article: Impact of mosaicism ratio on positive predictive value of <scp>cfDNA</scp> screening
Impact of mosaicism ratio on positive predictive value of <span>cfDNA</span> screening Open
Objective To examine the relationship between the fraction of cell‐free DNA (cfDNA) affected by aneuploidy compared to the overall fetal fraction of a prenatal screening specimen and its effect on positive predictive value (PPV). Method Cf…
View article: Cell‐free <scp>DNA</scp> screening in twin pregnancies: A more accurate and reliable screening tool
Cell‐free <span>DNA</span> screening in twin pregnancies: A more accurate and reliable screening tool Open
Objective Outcome data from cell‐free DNA (cfDNA) screening in twin gestations are limited. This study adds an appreciable number of confirmed outcomes to the literature, and assesses performance of cfDNA screening in twins over a 4.5‐year…
View article: Investigations of Hellenistic Mortar from Umm Qais (Gadara), Jordan
Investigations of Hellenistic Mortar from Umm Qais (Gadara), Jordan Open
Ancient mortars have been widely studied, in connection with both diagnosis and applications required for restoration. This study is primarily based on analyses of different mortar samples from a Hellenistic temple. The study was done by m…
View article: ISPD 2018 abstract author index
ISPD 2018 abstract author index Open
View article: Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing
Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing Open
BACKGROUND Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal cfDNA contributions are comingled, changes in the maternal genome can…
View article: Genome-wide cfDNA screening: clinical laboratory experience with the first 10,000 cases
Genome-wide cfDNA screening: clinical laboratory experience with the first 10,000 cases Open
View article: Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants
Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants Open