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View article: E3 ubiquitin ligase SKP2 limits autophagy during <i>S. aureus</i> infection
E3 ubiquitin ligase SKP2 limits autophagy during <i>S. aureus</i> infection Open
Ubiquitination is a posttranslational modification that affects protein function, stability, and localization and is thereby balancing protein homeostasis. During infection, ubiquitination is crucial in regulating host cell signaling pathw…
View article: Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells
Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells Open
Primary and acquired therapy resistance is a major problem in patients with BRAF-mutant melanomas being treated with BRAF and MEK inhibitors (BRAFI, MEKi). Therefore, development of alternative therapy regimes is still required. In this re…
View article: T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation Open
Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucle…
View article: The platelet proteasome and immunoproteasome are stable in buffy‐coat derived platelet concentrates for up to 7 days
The platelet proteasome and immunoproteasome are stable in buffy‐coat derived platelet concentrates for up to 7 days Open
Objectives Characterization of the proteasome and its stability in buffy‐coat derived platelet concentrates (PCs) during storage. Background The proteasome plays a key role in cell homeostasis by processing misfolded or abnormal proteins a…
View article: The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis
The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis Open
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis. However, upon inflammation, the sharp in…
View article: ER‐aminopeptidase 1 determines the processing and presentation of an immunotherapy‐relevant melanoma epitope
ER‐aminopeptidase 1 determines the processing and presentation of an immunotherapy‐relevant melanoma epitope Open
Dissecting the different steps of the processing and presentation of tumor‐associated antigens is a key aspect of immunotherapies enabling to tackle the immune response evasion attempts of cancer cells. The immunodominant glycoprotein gp10…