Eytan Herzig
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View article: 223 Anti-TnMuc1 CAR-T cells that are conditionally armed with IL12 eliminate adenocarcinomas in preclinical models
223 Anti-TnMuc1 CAR-T cells that are conditionally armed with IL12 eliminate adenocarcinomas in preclinical models Open
Background Chimeric antigen receptor T (CAR-T) cell therapeutics have been successful at driving remissions in several B cell malignancies, but their efficacy against most tumor types remains limited. An emerging strategy to increase CAR-T…
View article: CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir Open
There are currently over 35 million people living with HIV worldwide, and we still have no vaccine or scalable cure. One of the difficulties with HIV is its ability to rapidly establish a viral reservoir in lymphoid tissues that allows it …
View article: Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity <i>Ex Vivo</i> and <i>In Vivo</i>
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity <i>Ex Vivo</i> and <i>In Vivo</i> Open
If combined with immune therapeutics, latency-reversing agents (LRAs) have the potential to reduce the size of the reservoir sufficiently that an engineered immune response can control the virus in the absence of antiretroviral therapy. We…
View article: Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling
Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling Open
STUDY QUESTION Do seminal plasma (SP) and its constituents affect the decidualization capacity and transcriptome of human primary endometrial stromal fibroblasts (eSFs)? SUMMARY ANSWER SP promotes decidualization of eSFs from women with an…
View article: HIV-2 Depletes CD4 T Cells through Pyroptosis despite Vpx-Dependent Degradation of SAMHD1
HIV-2 Depletes CD4 T Cells through Pyroptosis despite Vpx-Dependent Degradation of SAMHD1 Open
CD4 T cell depletion during HIV-1 infection involves the demise of bystander CD4 T cells due to abortive infection, viral DNA sensing, inflammasome assembly, and death by caspase-1-dependent pyroptosis. HIV-2 infection is associated with m…
View article: HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication
HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication Open
HIV-1 is the causative agent of AIDS (Autoimmune Deficiency Syndrome). HIV-1 infection results in systemic CD4+ T cell depletion, thereby impairing cell-mediated immunity. MicroRNAs are short (~22 nucleotides long), endogenous single-stran…
View article: dUTPase: the frequently overlooked enzyme encoded by many retroviruses
dUTPase: the frequently overlooked enzyme encoded by many retroviruses Open
Retroviruses are among the best studied viruses in last decades due to their pivotal involvement in cellular processes and, most importantly, in causing human diseases, most notably-acquired immunodeficiency syndrome (AIDS) that is trigger…
View article: A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication
A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication Open
The process of reverse transcription (RTN) in retroviruses is essential to the viral life cycle. This key process is catalyzed exclusively by the viral reverse transcriptase (RT) that copies the viral RNA into DNA by its DNA polymerase act…
View article: MicroRNA regulation of p21 and TASK1 cellular restriction-factors enhances HIV-1 infection
MicroRNA regulation of p21 and TASK1 cellular restriction-factors enhances HIV-1 infection Open
MicroRNAs are short non-coding RNAs that play a central role in regulation of gene-expression by binding to target-gene mRNAs. Several studies have revealed alterations in cellular-miRNA profiles following HIV-1 infection, mostly inhibitin…