Ezra Blumenthal
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View article: The Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading Open
MicroRNA (miRNA) homeostasis is crucial for the posttranscriptional regulation of their target genes during development and in disease states. miRNAs are derived from primary transcripts and are processed from a hairpin precursor intermedi…
View article: Integrator enforces the fidelity of transcriptional termination at protein-coding genes
Integrator enforces the fidelity of transcriptional termination at protein-coding genes Open
Integrator directly binds and terminates protein-coding transcripts enriched in alternative polyadenylation sequences.
View article: The Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading Open
MicroRNA (miRNA) homeostasis is crucial for the post-transcriptional regulation of their target genes and miRNA dysregulation has been linked to multiple diseases, including cancer. The molecular mechanisms underlying miRNA biogenesis from…
View article: RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells Open
The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 is expressed in both estrogen receptor alpha (ER)-positive and ER-negative breast cancer (BC) …
View article: The Integrator complex at the crossroad of coding and noncoding RNA
The Integrator complex at the crossroad of coding and noncoding RNA Open
Genomic transcription is fundamental to all organisms. In metazoans, the Integrator complex is required for endonucleolytic processing of noncoding RNAs, regulation of RNA polymerase II pause-release, and premature transcription attenuatio…
View article: Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA <i>NEAT1</i>
Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA <i>NEAT1</i> Open
Integrator is a key regulator of NEAT1 isoform switching and, thereby, paraspeckles biogenesis and chemosensitivity.
View article: The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts Open
Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that Integrator subunit 11 (INTS11), the cata…
View article: Targeted chemotherapy overcomes drug resistance in melanoma
Targeted chemotherapy overcomes drug resistance in melanoma Open
The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growt…
View article: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis Open
View article: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis Open