Essak S. Khan
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View article: The bacterial molecular switch DnaA-ATP integrates chromosome replication with cell growth and division dynamics
The bacterial molecular switch DnaA-ATP integrates chromosome replication with cell growth and division dynamics Open
Successful proliferation of bacteria requires the coordination of multiple cellular events. The precise coordination between the replication of the chromosome with cell growth and division is essential for daughter cells to inherit an inta…
View article: HSP47 in human diseases: Navigating pathophysiology, diagnosis and therapy
HSP47 in human diseases: Navigating pathophysiology, diagnosis and therapy Open
Heat shock protein 47 (HSP47) is a chaperone protein responsible for regulating collagen maturation and transport, directly impacting collagen synthesis levels. Aberrant HSP47 expression or malfunction has been associated with collagen‐rel…
View article: Retraction: Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly
Retraction: Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly Open
Adv. Sci . 2019 , 6 , 1801982 DOI: 10.1002/advs.201801982 The above article, published online on May 3, 2019, in Wiley Online Library ( https://doi.org/10.1002/advs.201801982 ), has been retracted by agreement between the authors, the jour…
View article: Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond
Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond Open
R-loops are DNA–RNA hybrids that play multifunctional roles in gene regulation, including replication, transcription, transcription–replication collision, epigenetics, and preserving the integrity of the genome. The aberrant formation and …
View article: P1689: TISSUE-SELECTIVE PHARMACOLOGICAL TARGETING OF TUMOR INTRINSIC PROTHROMBIN (F2) EXPRESSION USING AN INTEGRATED GENETIC REPORTER SYSTEM
P1689: TISSUE-SELECTIVE PHARMACOLOGICAL TARGETING OF TUMOR INTRINSIC PROTHROMBIN (F2) EXPRESSION USING AN INTEGRATED GENETIC REPORTER SYSTEM Open
Background: Thrombin is the central protease involved in blood coagulation. Beyond its well-established role in stemming blood loss, it has a detrimental function in various (patho)physiological conditions including sepsis and various canc…
View article: Inhibition of Collagenase Q1 of <i>Bacillus cereus</i> as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Inhibition of Collagenase Q1 of <i>Bacillus cereus</i> as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections Open
Despite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity…
View article: Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices
Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices Open
Efficacy of cytotoxic T lymphocyte (CTL)-based immunotherapy is still unsatisfactory against solid tumors, which are frequently characterized by condensed extracellular matrix. Here, using a unique 3D killing assay, we identify that the ki…
View article: Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells
Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells Open
Solid tumors are often characterized by condensed extracellular matrix (ECM). The impact of dense ECM on cytotoxic T lymphocytes (CTL) function is not fully understood. Here, we report that CTL-mediated cytotoxicity is substantially impair…
View article: Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures <i>in vitro</i>
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures <i>in vitro</i> Open
Background Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders like Epidermolysis bullosa, EDS the ability to offer such stability is lost either due to mu…
View article: Retracted: Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly
Retracted: Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly Open
Collagen is the most abundant structural protein in mammals and is crucial for the mechanical integrity of tissues. Hsp47, an endoplasmic reticulum resident collagen‐specific chaperone, is involved in collagen biosynthesis and plays a fund…
View article: Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion &amp; Assembly
Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly Open
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assemb…
View article: Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion &amp; Assembly
Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly Open
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assemb…
View article: Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion &amp; Assembly
Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly Open
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assemb…
View article: Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly
Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly Open
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assemb…