Mashael Alqahtani
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View article: Airway pressure release ventilation as a recruitment maneuver in mechanically ventilated children with restrictive lung disease
Airway pressure release ventilation as a recruitment maneuver in mechanically ventilated children with restrictive lung disease Open
Rationale Restrictive lung disease is common in pediatric patients, leading to acute-on-chronic respiratory failure and the need for invasive mechanical ventilation. There is no consensus on lung recruitment maneuvers. Objectives To examin…
View article: Factors Associated with Intubation After Less Invasive Surfactant Administration (LISA); A Single-Center Cohort from Saudi Arabia
Factors Associated with Intubation After Less Invasive Surfactant Administration (LISA); A Single-Center Cohort from Saudi Arabia Open
Background: Less invasive surfactant administration (LISA) can reduce exposure to mechanical ventilation in preterm infants, but factors associated with LISA failure in routine practice remain uncertain, particularly outside Europe. Method…
View article: Trends, risk factors, and outcomes of unplanned extubation in a neonatal intensive care unit: a seven-year retrospective study
Trends, risk factors, and outcomes of unplanned extubation in a neonatal intensive care unit: a seven-year retrospective study Open
Background Unplanned extubation (UE) is a critical adverse event in neonatal intensive care units (NICUs), contributing to increased morbidity, prolonged mechanical ventilation, and potential complications such as airway trauma, ventilator…
View article: NanoRanger enables rapid single-base-pair resolution of genomic disorders
NanoRanger enables rapid single-base-pair resolution of genomic disorders Open
View article: Association of Polymorphisms in PD-1 and LAG-3 Genes with Acute Myeloid Leukemia
Association of Polymorphisms in PD-1 and LAG-3 Genes with Acute Myeloid Leukemia Open
Background and objectives: Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled proliferation of immature myeloid cells. Immune checkpoint molecules such as programmed cell death protein 1 (PD-1) and lym…
View article: TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia
TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia Open
This is the first study focusing on single nucleotide polymorphisms (SNPs) for CTLA-4 and TIM-3 in acute myeloid leukemia patients in a Saudi community and could be a potential new prognostic factor for this disease.
View article: The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants
The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants Open
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted over time, with normal memory αβ and high γδ T cell cou…
View article: Vitamin D-binding protein deficiency: an underrecognized Mendelian disorder of vitamin D metabolism
Vitamin D-binding protein deficiency: an underrecognized Mendelian disorder of vitamin D metabolism Open
View article: Beyond the exome: utility of long-read whole genome sequencing in exome-negative autosomal recessive diseases
Beyond the exome: utility of long-read whole genome sequencing in exome-negative autosomal recessive diseases Open
Background Long-read whole genome sequencing (lrWGS) has the potential to address the technical limitations of exome sequencing in ways not possible by short-read WGS. However, its utility in autosomal recessive Mendelian diseases is large…
View article: Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders Open
Recent studies using cell type-specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like-HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum-associated (E…
View article: NanoRanger enables rapid single base-pair resolution of genomic disorders
NanoRanger enables rapid single base-pair resolution of genomic disorders Open
Rare diseases affect around 350 million individuals globally, yet at least half of those with suspected Mendelian disorders remain without a precise molecular diagnosis despite advanced genetic testing using short read sequencing (SRS). Lo…
View article: Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families
Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families Open
View article: Corrigendum to “Anti- E. coli immunoglobulin yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load” [Heliyon 9(3) (February 21, 2023) e13876]>
Corrigendum to “Anti- E. coli immunoglobulin yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load” [Heliyon 9(3) (February 21, 2023) e13876]> Open
[This corrects the article DOI: 10.1016/j.heliyon.2023.e13876.].
View article: Impact of a multifaceted early mobility intervention for critically ill children — the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial
Impact of a multifaceted early mobility intervention for critically ill children — the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial Open
Background Over 50% of all critically ill children develop preventable intensive care unit-acquired morbidity. Early and progressive mobility is associated with improved outcomes in critically ill adults including shortened duration of mec…
View article: Anti-E. coli Immunoglobulin Yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load
Anti-E. coli Immunoglobulin Yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load Open
Graft versus host disease (GVHD) remains the major cause of morbidity and mortality after allogeneic stem cell transplantation, especially for intestinal GVHD, as steroid resistant GVHD results in high mortality. For this reason, new treat…
View article: Reactive Gingival Lesions, Investigations, And Treatment Modalities: Review Article
Reactive Gingival Lesions, Investigations, And Treatment Modalities: Review Article Open
Background and Objectives: Reactive gingival lesions (RGLs) are benign solitary swellings frequently responding to chronic inflammation of gingiva precipitated by local irritation. The research article was designed to discuss clinical and …
View article: Quantum Image Steganography Schemes for Data Hiding: A Survey
Quantum Image Steganography Schemes for Data Hiding: A Survey Open
Quantum steganography plays a critical role in embedding confidential data into carrier messages using quantum computing schemes. The quantum variant of steganography outperforms its classical counterpart from security, embedding efficienc…
View article: GP.6 Improving Triaging of EEG Referrals for Rule out Infantile Spasms (ITERIS)
GP.6 Improving Triaging of EEG Referrals for Rule out Infantile Spasms (ITERIS) Open
Background: Infantile spasms (IS) is a devastating pediatric seizure disorder for which EEG referrals are prioritized at the Hospital for Sick Children, representing a resource challenge. The goal of this study was to improve the triaging …
View article: Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update
Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update Open
There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases. One key line of evidence is the independent observation of p…
View article: Impact of using blogs on summary writing skills of EFL university students
Impact of using blogs on summary writing skills of EFL university students Open
This study examines the impact of using blogs on developing students’ summary writing skills and the perceptions of Saudi undergraduate EFL students on using blogs in developing their summary writing skills. The study participants comprise…
View article: Awareness of Oral Cancer Among Dental Patients in Mecca, Saudi Arabia
Awareness of Oral Cancer Among Dental Patients in Mecca, Saudi Arabia Open
Background: Oral Cancer (OC) is a serious health problem affecting the oral cavity, which may lead to death. Alcohol, tobacco, and chewing betel are the main risk factors. Early diagnosis and adequate knowledge of OC may improve the surviv…
View article: Hepatitis B: Knowledge, Preventive Attitude and Vaccine Status of Dental Students and Interns at Umm Al-Qura University, Makkah, Saudi Arabia
Hepatitis B: Knowledge, Preventive Attitude and Vaccine Status of Dental Students and Interns at Umm Al-Qura University, Makkah, Saudi Arabia Open
Background: Cross infection of blood-borne pathogens during dental practice is a major infection control problem among dental health care workers. Of these infections, Hepatitis B causes significant morbidity and mortality, and imposes a g…
View article: RELATIONSHIP BETWEEN SERUM VITAMIN D LEVEL AND RECURRENT APHTHOUS ULCER
RELATIONSHIP BETWEEN SERUM VITAMIN D LEVEL AND RECURRENT APHTHOUS ULCER Open
Introduction: Recurrent aphthous ulcer (RAU) is the most prevalent oral lesion.It is most commonly characterized by recurrent attacks of regular, oval or round, solitary or painful multiple ulcers and classified into three clinical forms; …
View article: CLINICAL EVALUATION OF USING BENZYDAMINE HYDROCHLORIDE ORAL GEL WITH INTRALESIONAL CORTICOSTEROID INJECTION FOR PAIN CONTROL IN SYMPTOMATIC ORAL LICHEN PLANUS
CLINICAL EVALUATION OF USING BENZYDAMINE HYDROCHLORIDE ORAL GEL WITH INTRALESIONAL CORTICOSTEROID INJECTION FOR PAIN CONTROL IN SYMPTOMATIC ORAL LICHEN PLANUS Open
Introduction:Lichen planus is a chronic inflammatory immune-mediated disease affecting skin and mucous membrane.Oral lichen planus (OLP) appears clinically as symmetrically distributed rough white striations on a mild background erythema.E…
View article: Effects of chlorhexidine, ethylenediaminetetraacetic acid, and sodium hypochlorite on cell viability of human gingival fibroblasts in vitro
Effects of chlorhexidine, ethylenediaminetetraacetic acid, and sodium hypochlorite on cell viability of human gingival fibroblasts in vitro Open
Introduction: The aim of this in vitro study was to evaluate the cytotoxic effects of chlorhexidine (CHX), ethylenediaminetetraacetic acid (EDTA), and sodium hypochlorite (NaOCl) irrigants on human gingival fibroblasts. Materials and Metho…
View article: Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein
Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein Open
Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic peptide (mrProANP), and adipocyte fatty-acid-binding proteins (A-FaBPs) have been i…