F. Arfelli
YOU?
Author Swipe
View article: Spectral phase-contrast X-ray imaging with high-resolution detectors
Spectral phase-contrast X-ray imaging with high-resolution detectors Open
X-ray phase contrast imaging (XPCI) records phase shifts in X-rays as they pass through matter, enabling the distinction of features, such as soft tissues, that have low contrast in conventional absorption-based methods. Phase contrast bea…
View article: A high sensitivity wide bandwidth spectral system for multiple K-edge imaging
A high sensitivity wide bandwidth spectral system for multiple K-edge imaging Open
Spectral K-edge subtraction (SKES) is an imaging technique that takes advantage of the sharp rise in the mass attenuation coefficient of specific elements within an object at their K-edge to produce separate and quantifiable distributions …
View article: Unveiling tumor invasiveness: enhancing cancer diagnosis with phase-contrast microtomography for 3D virtual histology
Unveiling tumor invasiveness: enhancing cancer diagnosis with phase-contrast microtomography for 3D virtual histology Open
Malignant diseases are characterized by a critical trait known as invasiveness, where tumor cells tend to spread from the primary tissue layer into surrounding healthy tissues and distant organs. Presently, histopathology offers essential …
View article: Spectral micro-CT for simultaneous gold and iodine detection, and multi-material identification
Spectral micro-CT for simultaneous gold and iodine detection, and multi-material identification Open
Multiple energy bin spectral micro-CT (S μ CT) is an advanced imaging technique that allows multi-material decomposition according to their specific absorption patterns at a sub-100 μm scale. Typically, iodine is the preferred CT contrast …
View article: Edge-illumination spectral phase-contrast tomography
Edge-illumination spectral phase-contrast tomography Open
Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination tech…
View article: Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis
Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis Open
Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent bidimensionality limits histological procedures’ effectiveness in identifying these changes. Our study applies a 3D virtual histology method based on …
View article: Experimental Characterization of Separate Absorption–Multiplication GaAs Staircase Avalanche Photodiodes under Continuous Laser Light Reveals Periodic Oscillations at High Gains
Experimental Characterization of Separate Absorption–Multiplication GaAs Staircase Avalanche Photodiodes under Continuous Laser Light Reveals Periodic Oscillations at High Gains Open
In this work, we experimentally analyze the periodic oscillations that take place in staircase APDs with separate absorption and multiplication regions when operating under continuous laser light. These oscillations increase in frequency w…
View article: On the equivalence of the X-ray scattering retrieval with beam tracking and analyser-based imaging using a synchrotron source
On the equivalence of the X-ray scattering retrieval with beam tracking and analyser-based imaging using a synchrotron source Open
X-ray phase contrast imaging (XPCI) methods give access to contrast mechanisms that are based on the refractive properties of matter on top of the absorption coefficient in conventional x-ray imaging. Ultra small angle x-ray scattering (US…
View article: High resolution propagation-based lung imaging at clinically relevant X-ray dose levels
High resolution propagation-based lung imaging at clinically relevant X-ray dose levels Open
Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spac…
View article: PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging
PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging Open
This paper presents a new flexible compact multi-modal imaging setup referred to as PEPI (Photon-counting Edge-illumination Phase-contrast imaging) Lab, which is based on the edge-illumination (EI) technique and a chromatic detector. The s…
View article: Study of gain, noise, and collection efficiency of GaAs SAM-APDs single pixel
Study of gain, noise, and collection efficiency of GaAs SAM-APDs single pixel Open
III-V-compound semiconductors offer many advantages over silicon-based technologies traditionally used in solid-state photodetectors, especially in hard X-ray applications that require high detection efficiency and short response times. Am…
View article: High Resolution Propagation-based Lung Imaging at Clinically Relevant X-Ray Dose Levels
High Resolution Propagation-based Lung Imaging at Clinically Relevant X-Ray Dose Levels Open
Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spac…
View article: Modeling Approaches for Gain, Noise and Time Response of Avalanche Photodiodes for X-Rays Detection
Modeling Approaches for Gain, Noise and Time Response of Avalanche Photodiodes for X-Rays Detection Open
We report on a suite of modeling approaches for the optimization of Avalanche Photodiodes for X-rays detection. Gain and excess noise are computed efficiently using a non-local/history dependent model that has been validated against full-b…
View article: Synchrotron Radiation Study of Gain, Noise, and Collection Efficiency of GaAs SAM-APDs with Staircase Structure
Synchrotron Radiation Study of Gain, Noise, and Collection Efficiency of GaAs SAM-APDs with Staircase Structure Open
In hard X-ray applications that require high detection efficiency and short response times, such as synchrotron radiation-based Mössbauer absorption spectroscopy and time-resolved fluorescence or photon beam position monitoring, III–V-comp…
View article: Optimization of a customized simultaneous algebraic reconstruction technique algorithm for phase-contrast breast computed tomography
Optimization of a customized simultaneous algebraic reconstruction technique algorithm for phase-contrast breast computed tomography Open
Objective. To introduce the optimization of a customized GPU-based simultaneous algebraic reconstruction technique (cSART) in the field of phase-contrast breast computed tomography (bCT). The presented algorithm features a 3D bilateral reg…
View article: Tomographic phase and attenuation extraction for a sample composed of unknown materials using x-ray propagation-based phase-contrast imaging
Tomographic phase and attenuation extraction for a sample composed of unknown materials using x-ray propagation-based phase-contrast imaging Open
Propagation-based phase-contrast x-ray imaging (PB-PCXI) generates image contrast by utilizing sample-imposed phase-shifts. This has proven useful when imaging weakly attenuating samples, as conventional attenuation-based imaging does not …
View article: On the possibility to utilize a PCO Edge 4.2 bi scientific CMOS imager for extended ultra violet and soft X-ray photon detection
On the possibility to utilize a PCO Edge 4.2 bi scientific CMOS imager for extended ultra violet and soft X-ray photon detection Open
A state of the art commercial detector, a PCO Edge 4.2 bi based on a back illuminated sCMOS sensor developed for applications in the visible light/ultra violet regime has been adapted for ultra-high vacuum operations and has been character…
View article: A Geant4 tool for edge-illumination X-ray phase-contrast imaging
A Geant4 tool for edge-illumination X-ray phase-contrast imaging Open
The PEPI project is developing a new experimental facility integrating a chromatic photon-counting detector within an edge-illumination (EI) phase-contrast setup. In this context, a novel Geant4-based simulation tool has been introduced wi…
View article: Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT
Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT Open
Purpose The SYRMA‐3D collaboration is setting up a breast computed tomography (bCT) clinical program at the Elettra synchrotron radiation facility in Trieste, Italy. Unlike the few dedicated scanners available at hospitals, synchrotron rad…
View article: Perspectives for microbeam irradiation at the SYRMEP beamline
Perspectives for microbeam irradiation at the SYRMEP beamline Open
It has been shown previously both in vitro and in vivo that microbeam irradiation (MBI) can control malignant tumour cells more effectively than the clinically established concepts of broad beam irradiation. With the aim to extend the inte…
View article: Full-Band Monte Carlo simulations of GaAs p-i-n Avalanche PhotoDiodes: What Are the Limits of Nonlocal Impact Ionization Models?
Full-Band Monte Carlo simulations of GaAs p-i-n Avalanche PhotoDiodes: What Are the Limits of Nonlocal Impact Ionization Models? Open
We present a Full-Band Monte Carlo (FBMC) investigation of impact ionization in GaAs p-i-n Avalanche Photodiodes (APDs). FBMC simulations have been used to compute the gain and the excess noise factor and a new equation has been derived fo…
View article: A novel approach to separate absorption, refraction and scattering in analyzer based lung imaging
A novel approach to separate absorption, refraction and scattering in analyzer based lung imaging Open
In analyzer based imaging (ABI) scattering can be efficiently separated from refraction and absorption effects by acquiring three images of the sample. In the scattering image the lungs appear as areas of high intensity signal (area contra…
View article: Experimental and simulation analysis of carrier lifetimes in GaAs/AlGaAs Avalanche Photo-Diodes
Experimental and simulation analysis of carrier lifetimes in GaAs/AlGaAs Avalanche Photo-Diodes Open
Extensive experimental characterization and TCAD simulation analysis have been used to study the dark current in Avalanche Photo-Diodes (APDs). The comparison between the temperature dependence of measurements and simulations points out th…
View article: Radiochromic film dosimetry in synchrotron radiation breast computed tomography: a phantom study
Radiochromic film dosimetry in synchrotron radiation breast computed tomography: a phantom study Open
This study relates to the INFN project SYRMA-3D for in vivo phase-contrast breast computed tomography using the SYRMEP synchrotron radiation beamline at the ELETTRA facility in Trieste, Italy. This peculiar imaging technique uses a novel d…
View article: Effects of p doping on GaAs/AlGaAs SAM-APDs for X-rays detection
Effects of p doping on GaAs/AlGaAs SAM-APDs for X-rays detection Open
Avalanche photodiodes based on GaAs/AlGaAs with separated absorption and multiplication
\nregions (SAM-APDs) will be discussed in terms of capacitance, response to light (gain
\nand noise) and time response. The structures have been fabric…
View article: Flattening filter for Gaussian-shaped monochromatic X-ray beams: an application to breast computed tomography
Flattening filter for Gaussian-shaped monochromatic X-ray beams: an application to breast computed tomography Open
The vertical intensity distribution of synchrotron-based X-ray beams usually has a Gaussian profile encompassing large intensity variations. For biomedical imaging applications this may entail sub-optimal dose distributions and large fluct…