Arrigo F.G. Cicero
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Managing Gut Dysbiosis: Clinical Evidence and Perspectives on Saccharomyces boulardii CNCM I-745 for Diarrhoeal Conditions in Adults and Children Open
The human gut microbiota plays a key role in health and disease across the lifespan and is shaped by complex intrinsic and extrinsic factors. Dysbiosis is increasingly recognized as a contributor to a wide range of clinical conditions, wit…
View article: ASSESSMENT OF HEAVY METALS AND PAHs IN FISH WASTE VALORISATION FOR NUTRACEUTICAL PURPOSES
ASSESSMENT OF HEAVY METALS AND PAHs IN FISH WASTE VALORISATION FOR NUTRACEUTICAL PURPOSES Open
This study presents results on contaminant quantifications for the food safety of initial biomass (fish waste) and its extract product (fish oil) resulting from the activities carried out within the VITADWASTE project. VITADWASTE is a PRIN…
View article: Reprogramming the Mitochondrion in Atherosclerosis: Targets for Vascular Protection
Reprogramming the Mitochondrion in Atherosclerosis: Targets for Vascular Protection Open
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with a substantial proportion of events occurring prematurely. Atherosclerosis (AS), the central driver of cardiovascular pathology, results from the convergence o…
View article: Sex differences in inflammatory biomarkers during long-term evolocumab therapy
Sex differences in inflammatory biomarkers during long-term evolocumab therapy Open
Our findings reveal pronounced biological sex differences in inflammatory responses to long-term evolocumab therapy, highlighting the need to incorporate sex-specific considerations in cardiovascular risk management and treatment monitorin…
View article: Crystal clear – Part II: the role of uric acid in cardiorenal disease
Crystal clear – Part II: the role of uric acid in cardiorenal disease Open
Building on the foundational mechanistic and epidemiological knowledge from Part I, this second part of the review further unpacks the cardiovascular implications of abnormalities in serum levels of uric acid (UA). With a focus on hyperten…
View article: The Interplay Between Diet-related Inflammation, Helicobacter pylori infection, and Gastric Cancer Risk
The Interplay Between Diet-related Inflammation, Helicobacter pylori infection, and Gastric Cancer Risk Open
Background: Diet plays a critical role in modulating inflammation and may influence the development of gastric cancer. This study aimed to evaluate and compare the Dietary Inflammatory Index (DII) and the consumption of specific foods asso…
View article: Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber Neuropathy
Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber Neuropathy Open
Fibromyalgia is a complex disorder characterized by chronic widespread pain and a variety of related symptoms. Growing evidence suggests that the central and peripheral nervous systems are involved, with small fiber neuropathy playing a ke…
View article: Crystal clear – part I: The role of uric acid in cardiorenal disease
Crystal clear – part I: The role of uric acid in cardiorenal disease Open
This review opens a two-part series by exploring the evolutionary origins, vascular implications, renal pathophysiology, and prognosis related to serum uric acid (SUA). We begin by examining the ancestral loss of uricase in hominoids, whic…
View article: Incidence, Associated Abnormalities, and Outcomes of Dextrocardia: A Registry-Based Study in Saudi Arabia
Incidence, Associated Abnormalities, and Outcomes of Dextrocardia: A Registry-Based Study in Saudi Arabia Open
This study describes the largest regional cohort of patients with dextrocardia, providing important insights into dextrocardia and outcomes of different intracardiac defects in our community. Our findings confirm that complex congenital ca…
View article: Definition of maximum daily amounts of vitamins and minerals allowed in food supplements: scientific rationale and European regulatory frameworks
Definition of maximum daily amounts of vitamins and minerals allowed in food supplements: scientific rationale and European regulatory frameworks Open
Ensuring an adequate supply of essential micronutrients while preventing excessive in-takes that could lead to adverse effects presents a challenge in the context of food supplement regulation, in the absence of harmonization in the Europe…
View article: A 360° Perspective on Cardiovascular Prevention: the International Lipid Expert Panel SiMple tIps for the heaLthy hEart (ILEP-SMILE)
A 360° Perspective on Cardiovascular Prevention: the International Lipid Expert Panel SiMple tIps for the heaLthy hEart (ILEP-SMILE) Open
Despite decades of research into lifestyle factors and medications, we still cannot effectively prevent the occurrence of ASCVD and its complications. Yet, only a small percentage of the healthcare budget is allocated to prevention, and on…
Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), the Italian Society of Dermatology and Sexually Transmitted Diseases (SIDeMaST), the Italian Society of Nutraceuticals (SINut), Club Ketodiets and Nutraceuticals “KetoNut-SINut” and the Italian Society of Endocrinology (SIE), Club Nutrition, Hormones and Metabolism Open
Summary Dermatological diseases such as acne, hidradenitis suppurativa (HS), and psoriasis are driven by chronic inflammation and oxidative stress. Emerging evidence highlights the role of nutrition in modulating these conditions, particul…
View article: The effect of highly bioavailable forms of curcumin on lipoprotein(a) plasma levels: A systematic review and meta-analysis of randomized clinical studies
The effect of highly bioavailable forms of curcumin on lipoprotein(a) plasma levels: A systematic review and meta-analysis of randomized clinical studies Open
Curcumin is a bioactive compound derived from the rhizome of Curcuma longa (turmeric) that has garnered increasing attention for its potential health benefits. However, its use in clinical practice is limited due to its generally poor bioa…
View article: Reliability of different formulas for estimating plasma Apolipoprotein B levels in a large cohort of South European individuals
Reliability of different formulas for estimating plasma Apolipoprotein B levels in a large cohort of South European individuals Open
Some simple formulas based on low-cost and widely available parameters can estimate ApoB levels independently of ApoB, non-HDL-C, and Lp(a) plasma levels. This approach may be particularly useful for estimating ApoB levels in low-resource …
View article: Establishing a Bioink Assessment Protocol: GelMA and Collagen in the Bioprinting of a Potential <i>In Vitro</i> Intestinal Model
Establishing a Bioink Assessment Protocol: GelMA and Collagen in the Bioprinting of a Potential <i>In Vitro</i> Intestinal Model Open
Collagen and gelatin methacryloyl (GelMA) are widely studied biomaterials for extrusion-based bioprinting (EBB) due to their excellent biological properties and ability to mimic the extracellular matrix of native tissues. This study aims t…
View article: Proprotein convertase subtilisin/kexin type 9: a promising marker of cardiovascular risk in post-menopausal diabetic women in primary prevention
Proprotein convertase subtilisin/kexin type 9: a promising marker of cardiovascular risk in post-menopausal diabetic women in primary prevention Open
Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases circulating LDL levels and cardiovascular disease (CVD) risk; its levels may be related to the dysregulation of glycemic control and may be affected by est…
View article: Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey
Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey Open
Purpose The delayed or missed diagnosis of secondary hypertension contributes to the poor blood pressure control worldwide. This study aimed to assess the diagnostic approach to primary aldosteronism (PA) and pheochromocytoma (PHEO) among …
View article: Management of children with heterozygous familial hypercholesterolaemia worldwide: a meta-analysis
Management of children with heterozygous familial hypercholesterolaemia worldwide: a meta-analysis Open
Aims Heterozygous familial hypercholesterolaemia (HeFH) is one of the most frequent monogenic disorders in the world, leading to premature atherosclerotic cardiovascular diseases. The aim of this meta-analysis was to evaluate the efficacy …
View article: Nutraceuticals and Supplements in Management of Prediabetes and Diabetes
Nutraceuticals and Supplements in Management of Prediabetes and Diabetes Open
Dysglycemia is a condition preceding diabetes mellitus. The two situations inherent in this condition are called impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). If one of these situations is found in the patient, after…
View article: Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study
Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study Open
Background Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributing to IR, while IR is a known predictor for the development of hyperu…
View article: Palmitoylethanolamide in Postmenopausal Metabolic Syndrome: Current Evidence and Clinical Perspectives
Palmitoylethanolamide in Postmenopausal Metabolic Syndrome: Current Evidence and Clinical Perspectives Open
Menopause leads to a decline in estrogen levels, resulting in significant metabolic alterations that increase the risk of developing metabolic syndrome—a cluster of conditions including central obesity, insulin resistance, dyslipidemia, an…
View article: Reducing the global prevalence of cardiometabolic risk factors: a bet worth winning
Reducing the global prevalence of cardiometabolic risk factors: a bet worth winning Open
The prevalence of potentially preventable and reversible cardiometabolic risk factors continues to increase in many countries around the world. The importance of this has been emphasised once again by the Investigators of the Global Burden…
View article: Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship
Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship Open
The growing recognition of the public health impact of cognitive impairment and dementia has sparked a global initiative to identify risk factors and develop strategies to prevent or slow the progression of these cognitive disorders. Uric …