Fouzi Bala
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View article: Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes
Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes Open
Background Infarct volume is an imaging biomarker of ischemic tissue injury strongly correlated with poststroke outcomes and reperfusion benefit. We aimed to evaluate the follow‐up infarct volume (FIV) difference corresponding to a 1%, 5%,…
View article: Multiple Health Care Encounters Prior to Diagnosis of Cerebral Venous Thrombosis
Multiple Health Care Encounters Prior to Diagnosis of Cerebral Venous Thrombosis Open
Women were more likely to have multiple health care encounters prior to cerebral venous thrombosis diagnosis. However, this was not associated with worse outcomes.
View article: Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke Open
Importance The cumulative burden of chronic vascular and neurodegenerative changes contributes to brain frailty, which may reduce the brain’s capacity to recover from acute ischemic stroke (AIS). The association between brain frailty marke…
MRI versus CT before endovascular thrombectomy in the early time window: A systematic review and meta-analysis Open
In stroke patients undergoing EVT within 6 h from symptom onset, MRI before EVT could be a feasible alternative to CT without significant delays from door to puncture time. Randomized trials are needed before these findings can be generali…
Indirect flow diversion for the treatment of saccular posterior inferior cerebellar artery aneurysms: An 11-year single-center retrospective study Open
Introduction Posterior inferior cerebellar artery (PICA) aneurysms are rare but associated with high rupture rates and significant morbidity and mortality. Both surgical and endovascular treatments can be technically challenging. This stud…
View article: Tenecteplase versus Alteplase and First-Pass Reperfusion in Endovascular Thrombectomy
Tenecteplase versus Alteplase and First-Pass Reperfusion in Endovascular Thrombectomy Open
IV thrombolytic agent did not influence the probability of first-pass reperfusion.
View article: Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial
Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial Open
Introduction: Post-stroke cognitive impairment is associated with impaired quality of life. Remote testing provides a potential avenue to measure cognitive outcomes efficiently. Patients and Methods: Prospective cognitive outcomes were col…
View article: Intravenous thrombolysis at primary stroke centers versus comprehensive stroke centers: Analysis from the AcT trial
Intravenous thrombolysis at primary stroke centers versus comprehensive stroke centers: Analysis from the AcT trial Open
Introduction Fast delivery of intravenous thrombolysis (IVT) and transportation to a comprehensive stroke center (CSC) is paramount in primary stroke centers (PSCs), to achieve effective reperfusion. We investigated clinical outcomes and w…
View article: Impact of workflow times on successful reperfusion after endovascular treatment in the late time window
Impact of workflow times on successful reperfusion after endovascular treatment in the late time window Open
Background and Purpose Successful and complete reperfusion should be the aim of every endovascular thrombectomy (EVT) procedure. However, the effect of time delays on successful reperfusion in late window stroke patients presenting 6-to-24…
View article: Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial
Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial Open
Background About 25% of patients with acute ischemic stroke have lacunar infarct on follow‐up imaging. In this secondary analysis from the AcT (Alteplase Compared With Tenecteplase) trial, we assessed if there is variation in safety or eff…
View article: The treatment effect across ASPECTS in acute ischemic stroke: Analysis from the AcT trial
The treatment effect across ASPECTS in acute ischemic stroke: Analysis from the AcT trial Open
Background: Early ischemic changes on baseline imaging are commonly evaluated for acute stroke decision-making and prognostication. Aims: We assess the association of early ischemic changes on clinical outcomes and whether it differs betwe…
Tenecteplase Versus Alteplase in Medium Vessel Occlusion Ischemic Stroke: A Secondary Analysis of the Alteplase Compared to Tenecteplase Randomized Trial Open
Background and Purpose The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO.Methods Patie…
View article: B.2 Time from symptom onset and number of health care encounters prior to diagnosis of cerebral venous thrombosis
B.2 Time from symptom onset and number of health care encounters prior to diagnosis of cerebral venous thrombosis Open
Background: Cerebral venous thrombosis (CVT)most commonly affects younger women. Diagnosis may be delayed due to its distinct presentation and demographic profile compared to other stroke types. Methods: We examined delays to diagnosis of …
View article: Workflow and Outcome of Thrombectomy in Late Time Window: A Pooled Multicenter Analysis
Workflow and Outcome of Thrombectomy in Late Time Window: A Pooled Multicenter Analysis Open
Background: We investigated the impact of workflow times on the outcomes of patients treated with endovascular thrombectomy (EVT) in the late time window. Methods: Individual patients’ data who underwent EVT in the late time window (onset …
View article: Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial
Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial Open
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability. We compared the efficacy and safety of intr…
View article: Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke
Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke Open
Importance Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-makin…
Safety and efficacy of Surpass Evolve Flow diverter for intracranial aneurysms: A study of 116 patients Open
Background and purpose Flow diverter embolization is a recognized method for treating intracranial aneurysms. This study evaluates the safety and efficacy of the Surpass Evolve flow diverter in treating intracranial aneurysm. Material and …
View article: Reperfusion therapies for ischemic stroke in dementia and cognitive impairment: A systematic review and meta-analysis
Reperfusion therapies for ischemic stroke in dementia and cognitive impairment: A systematic review and meta-analysis Open
Background: Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) have an unclear benefit in those with pre-stroke dementia or cognitive impairment, as these patients were often excluded from landmark stroke trials. We perform…
View article: Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial
Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial Open
Background: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15–20% of acute stroke with large vessel occlusion. Aims: We investigated the safety and efficacy of intravenous tenecteplase (0.25 mg/kg) versus intravenous …
View article: Study of Rivaroxaban for Cerebral Venous Thrombosis: A Randomized Controlled Feasibility Trial Comparing Anticoagulation With Rivaroxaban to Standard-of-Care in Symptomatic Cerebral Venous Thrombosis
Study of Rivaroxaban for Cerebral Venous Thrombosis: A Randomized Controlled Feasibility Trial Comparing Anticoagulation With Rivaroxaban to Standard-of-Care in Symptomatic Cerebral Venous Thrombosis Open
BACKGROUND: Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation for cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it is a rare disease with…
Cortical and Subcortical Brain Atrophy Assessment Using Simple Measures on NCCT Compared with MRI in Acute Stroke Open
Brain atrophy can be evaluated using simple measures in emergently acquired NCCT. Subcortical atrophy assessments on NCCT show strong correlations with MR imaging. Although cortical atrophy assessments on NCCT are strongly correlated with …
Association of Brain Atrophy With Functional Outcome and Recovery Trajectories After Thrombectomy Open
In this large RCT-derived population, participants with brain atrophy, as visually assessed on acute noncontrast computed tomography imaging, showed less favorable stroke recovery after EVT and worse 90-day functional outcomes compared wit…
View article: Safety and Efficacy of Tenecteplase Compared With Alteplase in Patients With Large Vessel Occlusion Stroke
Safety and Efficacy of Tenecteplase Compared With Alteplase in Patients With Large Vessel Occlusion Stroke Open
Importance It is unknown whether intravenous thrombolysis using tenecteplase is noninferior or preferable compared with alteplase for patients with acute ischemic stroke. Objective To examine the safety and efficacy of tenecteplase compare…
Persistent flow inside the Woven EndoBridge at angiographic follow-up: A multicenter study Open
Background The occurrence of persistent intra-device filling (BOSS 1, using the Bicêtre Occlusion Scale Score (BOSS)) in aneurysms treated with a Woven Endobridge (WEB) device is infrequent based on angiographic follow-up. To date, three m…