Tone F. Bathen
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View article: Development and evaluation of a lymph node invasion risk prediction model in intermediate- and high-risk prostate cancer patients
Development and evaluation of a lymph node invasion risk prediction model in intermediate- and high-risk prostate cancer patients Open
Background and purpose: Many prostate cancer patients undergoing pelvic lymph node dissection (PLND) have no sign of lymph node invasion (LNI) during final pathological assessment. To improve preoperative staging accuracy, we developed the…
View article: Optimizing Federated Learning Configurations for MRI Prostate Segmentation and Cancer Detection: A Simulation Study
Optimizing Federated Learning Configurations for MRI Prostate Segmentation and Cancer Detection: A Simulation Study Open
Federated learning enables collaborative model training, enhancing the performance and generalizability of trained models for MRI-based prostate gland segmentation and clinically significant prostate cancer detection compared with locally …
View article: Incorporating Spatial and Spectral Saturation Modules Into MR Fingerprinting
Incorporating Spatial and Spectral Saturation Modules Into MR Fingerprinting Open
In this work, we introduce spatial and chemical saturation options for artefact reduction in magnetic resonance fingerprinting (MRF) and assess their impact on T 1 and T 2 mapping accuracy. An existing radial MRF pulse sequence was modifie…
View article: Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals
Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals Open
An extensive network of microbial-host interactions exists in the gut, making the gut microbiome a complex ecosystem to untangle. The microbial composition and the fecal metabolites are important readouts to investigate intricate microbiot…
View article: Repeat Prostate-specific Antigen Testing Improves Risk-based Selection of Men for Prostate Biopsy After Magnetic Resonance Imaging
Repeat Prostate-specific Antigen Testing Improves Risk-based Selection of Men for Prostate Biopsy After Magnetic Resonance Imaging Open
For men with a suspicion of prostate cancer, repeat PSA (prostate-specific antigen) testing after an MRI (magnetic resonance imaging) scan can help in identifying patients who can safely avoid prostate biopsy.
View article: Deep learning for automated scoring of immunohistochemically stained tumour tissue sections – Validation across tumour types based on patient outcomes
Deep learning for automated scoring of immunohistochemically stained tumour tissue sections – Validation across tumour types based on patient outcomes Open
We aimed to develop deep learning (DL) models to detect protein expression in immunohistochemically (IHC) stained tissue-sections, and to compare their accuracy and performance with manually scored clinically relevant proteins in common ca…
View article: Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes Open
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of BC pose challenges for survival prediction, as patients with similar diagnoses often respond differently to treatment.…
View article: Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis
Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis Open
Introduction Systemic and local steroid hormone levels may function as novel prognostic and predictive biomarkers in breast cancer patients. We aimed at developing a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method fo…
View article: Added Value of [<scp>18F</scp>]<scp>PSMA</scp>‐1007 <scp>PET</scp>/<scp>CT</scp> and <scp>PET</scp>/<scp>MRI</scp> in Patients With Biochemically Recurrent Prostate Cancer: Impact on Detection Rates and Clinical Management
Added Value of [<span>18F</span>]<span>PSMA</span>‐1007 <span>PET</span>/<span>CT</span> and <span>PET</span>/<span>MRI</span> in Patients With Biochemically Recurrent Prostate Cancer: Impact on Detection Rates and Clinical Management Open
Background Prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) can change management in a large fraction of patients with biochemically recurrent prostate cancer (BCR). Purpose To investigate the added value of PET…
View article: Profiling of serum metabolome of breast cancer: multi-cancer features discriminate between healthy women and patients with breast cancer
Profiling of serum metabolome of breast cancer: multi-cancer features discriminate between healthy women and patients with breast cancer Open
Introduction The progression of solid cancers is manifested at the systemic level as molecular changes in the metabolome of body fluids, an emerging source of cancer biomarkers. Methods We analyzed quantitatively the serum metabolite profi…
View article: Reducing femoral flow artefacts in radial magnetic resonance fingerprinting of the prostate using region‐optimised virtual coils
Reducing femoral flow artefacts in radial magnetic resonance fingerprinting of the prostate using region‐optimised virtual coils Open
High acceleration factors in radial magnetic resonance fingerprinting (MRF) of the prostate lead to strong streak‐like artefacts from flow in the femoral blood vessels, possibly concealing important anatomical information. Region‐optimised…
View article: A multivariate curve resolution analysis of multicenter proton spectroscopic imaging of the prostate for cancer localization and assessment of aggressiveness
A multivariate curve resolution analysis of multicenter proton spectroscopic imaging of the prostate for cancer localization and assessment of aggressiveness Open
In this study, we investigated the potential of the multivariate curve resolution alternating least squares (MCR‐ALS) algorithm for analyzing three‐dimensional (3D) 1 H‐MRSI data of the prostate in prostate cancer (PCa) patients. MCR‐ALS g…
View article: Restriction spectrum imaging with elastic image registration for automated evaluation of response to neoadjuvant therapy in breast cancer
Restriction spectrum imaging with elastic image registration for automated evaluation of response to neoadjuvant therapy in breast cancer Open
Purpose Dynamic contrast-enhanced MRI (DCE) and apparent diffusion coefficient (ADC) are currently used to evaluate treatment response of breast cancer. The purpose of the current study was to evaluate the three-component Restriction Spect…
View article: Pelvic PET/MR attenuation correction in the image space using deep learning
Pelvic PET/MR attenuation correction in the image space using deep learning Open
Introduction The five-class Dixon-based PET/MR attenuation correction (AC) model, which adds bone information to the four-class model by registering major bones from a bone atlas, has been shown to be error-prone. In this study, we introdu…
View article: Performance of magnetic resonance imaging‐based prostate cancer risk calculators and decision strategies in two large European medical centres
Performance of magnetic resonance imaging‐based prostate cancer risk calculators and decision strategies in two large European medical centres Open
Objectives To compare the performance of currently available biopsy decision support tools incorporating magnetic resonance imaging (MRI) findings in predicting clinically significant prostate cancer (csPCa). Patients and Methods We retros…
View article: The association between circulating lipoprotein subfractions and lipid content in coronary atheromatous plaques assessed by near-infrared spectroscopy
The association between circulating lipoprotein subfractions and lipid content in coronary atheromatous plaques assessed by near-infrared spectroscopy Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Norwegian Health Association The Liaison Committee for education, research and innovation in Central Norway. Background Lipid content in coronary atherom…
View article: Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study Open
Background Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI. Aim We aimed to identify …
View article: Supplementary Materials IV: Supplementary Figures S71-106 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials IV: Supplementary Figures S71-106 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).
View article: Supplementary Materials III: Supplementary Figures S41-70 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials III: Supplementary Figures S41-70 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).
View article: Supplementary Materials II: Supplementary Figures S1-40 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials II: Supplementary Figures S1-40 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).
View article: Supplementary Materials II: Supplementary Figures S1-40 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials II: Supplementary Figures S1-40 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).
View article: Supplementary Materials I: Supplementary Tables S1-3 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials I: Supplementary Tables S1-3 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Mean (95% CI) for all performance measures the U.S. dataset (Supplementary Table S1) and European dataset (Supplementary Table S2). Median (interquartile range) for average signal of the cancer and control regions of interests (ROIs) for b…
View article: Data from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Data from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Purpose:Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from all other breast t…
View article: Supplementary Materials IV: Supplementary Figures S71-106 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials IV: Supplementary Figures S71-106 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).
View article: Supplementary Materials III: Supplementary Figures S41-70 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Supplementary Materials III: Supplementary Figures S41-70 from Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model Open
Probability density colormaps for the three-component model given C1 and C2 for all voxels per patient for (A.) cancer (cancer ROI) and (B.) healthy breast tissue (control ROI).