John F. Bertram
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View article: Nephron Number and Kidney Outcomes in IgA Nephropathy
Nephron Number and Kidney Outcomes in IgA Nephropathy Open
Background: We previously reported substantial variability in the number of nephrons in patients with IgA nephropathy (IgAN), even among patients with similar risk factor profiles. This retrospective cohort study aimed to evaluate the clin…
View article: Counting glomeruli in human kidney specimens using ex vivo <scp>MRI</scp> without contrast agents
Counting glomeruli in human kidney specimens using ex vivo <span>MRI</span> without contrast agents Open
Purpose The total number of glomeruli is an important indicator of kidney function and susceptibility to disease. Glomeruli, however, are difficult to image using MRI without contrast enhancement. For this reason, previous studies have use…
View article: Nephron Number and Kidney Outcomes in IgA Nephropathy: A Retrospective Cohort Study
Nephron Number and Kidney Outcomes in IgA Nephropathy: A Retrospective Cohort Study Open
Background We previously reported substantial variability in the number of nephrons in patients with IgA nephropathy (IgAN), even among patients with similar risk factor profiles. This retrospective cohort study aimed to evaluate the clini…
View article: The Validation of Antibodies Suitable for Flow Cytometric Analysis and Immunopeptidomics of Peptide–MHC Complexes in the Outbred Swiss Albino Mouse Strain
The Validation of Antibodies Suitable for Flow Cytometric Analysis and Immunopeptidomics of Peptide–MHC Complexes in the Outbred Swiss Albino Mouse Strain Open
Antigen presentation on major histocompatibility complex (MHC) molecules is central to the initiation of immune responses, and a lot of our understanding about the antigen processing and presentation pathway has been gained through studies…
View article: Validation of Antibodies Suitable for Flow Cytometric Analysis and Immunopeptidomics of Peptide-MHC Complexes in the Outbred Swiss Albino Mouse Strain
Validation of Antibodies Suitable for Flow Cytometric Analysis and Immunopeptidomics of Peptide-MHC Complexes in the Outbred Swiss Albino Mouse Strain Open
Antigen presentation on major histocompatibility complex (MHC) molecules is central to the initiation of immune responses and a lot of our understanding about the antigen processing and presentation pathway has been gained through studies …
View article: Alterations to peritubular capillary structure in a rat model of kidney interstitial fibrosis: Implications for oxygen diffusion
Alterations to peritubular capillary structure in a rat model of kidney interstitial fibrosis: Implications for oxygen diffusion Open
Fibrosis and loss of functional capillary surface area may contribute to renal tissue hypoxia in a range of kidney diseases. However, there is limited quantitative information on the impact of kidney disease on the barriers to oxygen diffu…
View article: Applying 3D surface scanning technology to create photorealistic three-dimensional printed replicas of human anatomy
Applying 3D surface scanning technology to create photorealistic three-dimensional printed replicas of human anatomy Open
Aim: To describe advances in 3D data capture and printing that allow photorealistic replicas of human anatomical specimens for education and research, and discuss advantages of current generation printing for replica design and manufacture…
View article: Podocyte density as a predictor of long-term kidney outcome in obesity-related glomerulopathy
Podocyte density as a predictor of long-term kidney outcome in obesity-related glomerulopathy Open
Glomerulomegaly and focal segmental glomerulosclerosis are histopathological hallmarks of obesity-related glomerulopathy (ORG). Podocyte injury and subsequent depletion are regarded as key processes in the development of these glomerular l…
View article: Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis
Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis Open
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatm…
View article: The Impact of Low Protein Diet on the Molecular and Cellular Development of the Fetal Kidney
The Impact of Low Protein Diet on the Molecular and Cellular Development of the Fetal Kidney Open
Background Low nephron number has a direct impact on the development of hypertension and chronic kidney disease later in life. While intrauterine growth restriction caused by maternal low protein diet (LPD) is thought to be a significant c…
View article: Multi-breed genomic predictions and functional variants for fertility of tropical bulls
Multi-breed genomic predictions and functional variants for fertility of tropical bulls Open
Worldwide, most beef breeding herds are naturally mated. As such, the ability to identify and select fertile bulls is critically important for both productivity and genetic improvement. Here, we collected ten fertility-related phenotypes f…
View article: Cardiovascular and renal profiles in rat offspring that do not undergo catch-up growth after exposure to maternal protein restriction
Cardiovascular and renal profiles in rat offspring that do not undergo catch-up growth after exposure to maternal protein restriction Open
Maternal protein restriction is often associated with structural and functional sequelae in offspring, particularly affecting growth and renal-cardiovascular function. However, there is little understanding as to whether hypertension and k…
View article: Nephron deficit and low podocyte density increase risk of albuminuria and glomerulosclerosis in a model of diabetes
Nephron deficit and low podocyte density increase risk of albuminuria and glomerulosclerosis in a model of diabetes Open
Podocytes are terminally differentiated epithelial cells in glomeruli. Podocyte injury and loss are features of many diseases leading to chronic kidney disease (CKD). The developmental origins of health and disease hypothesis propose an ad…
View article: Associations between nephron number and podometrics in human kidneys
Associations between nephron number and podometrics in human kidneys Open
Podocyte loss and resultant nephron loss are common processes in the development of glomerulosclerosis and chronic kidney disease. While the cortical distribution of glomerulosclerosis is known to be non-uniform, the relationship between t…
View article: The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age
The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age Open
Progressive podocyte loss is a feature of healthy ageing. While previous studies have reported age-related changes in podocyte number, density and size and associations with proteinuria and glomerulosclerosis, few studies have examined how…
View article: Personal Reflections on the Life of Hans Jørgen Gottlieb Gundersen
Personal Reflections on the Life of Hans Jørgen Gottlieb Gundersen Open
Professor Hans Jørgen G. Gundersen MD, DMSc (1943–2021) was a pioneering stereologist whose work has inspired and influenced researchers across the world for almost half a century. He was a charismatic character and one of the founding fat…
View article: Clearly imaging and quantifying the kidney in 3D
Clearly imaging and quantifying the kidney in 3D Open
For decades, measurements of kidney microanatomy using 2-dimensional sections has provided us with a detailed knowledge of kidney morphology under physiological and pathological conditions. However, the rapid development of tissue clearing…
View article: Total Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy
Total Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy Open
Key Points This is the first study that estimated total nephron number and related single-nephron parameters in patients with IgA nephropathy. Associations of nephron-level parameters with CKD stage and clinicopathologic findings were cros…
View article: Podometrics in Japanese Living Donor Kidneys: Associations with Nephron Number, Age, and Hypertension
Podometrics in Japanese Living Donor Kidneys: Associations with Nephron Number, Age, and Hypertension Open
Significance Statement Podocyte depletion and low nephron number are associated with glomerulosclerosis and CKD. However, the relationship between podometrics and nephron number has not previously been reported. The authors estimated podom…