Elena Bossi
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View article: Adjunctive acetazolamide for drug‐resistant seizures in <scp>SLC6A1</scp> ‐related neurodevelopmental disorder: An exploratory case series
Adjunctive acetazolamide for drug‐resistant seizures in <span>SLC6A1</span> ‐related neurodevelopmental disorder: An exploratory case series Open
Pathogenic variants in SLC6A1 cause a neurodevelopmental disorder characterized by developmental delay with behavioral disturbances, seizures, often pharmacoresistant, and a spectrum of movement disorders such as ataxia. A similar triad is…
View article: Delineating plant responses to the 3’,5’- and 2’,3’-cAMP isomers
Delineating plant responses to the 3’,5’- and 2’,3’-cAMP isomers Open
Similar to animals, both the 3’,5- and the 2,’3’-cAMP isomers are present in plants. The former is the enzymatic product of adenylate cyclases (ACs), the latter is an RNA degradation product. While there is increasing evidence that both is…
View article: Variables influencing the <i>in vitro</i> measurement of spontaneous aggregation of human platelets
Variables influencing the <i>in vitro</i> measurement of spontaneous aggregation of human platelets Open
Not available.
View article: Investigating the Interplay of SARS-CoV-2 RNAemia and Peripheral Inflammation in Platelet Dysfunction During Acute SARS-CoV-2 Infection
Investigating the Interplay of SARS-CoV-2 RNAemia and Peripheral Inflammation in Platelet Dysfunction During Acute SARS-CoV-2 Infection Open
Background: Circulating degranulated platelets have been described during acute SARS-CoV-2 infection and associated with COVID-19 complications. This study investigated the relationship between the presence of plasma SARS-CoV-2 RNA (ie, SA…
View article: Differential transcript and soluble factor patterns in macrophage/enterocyte-like monolayer co-cultures based on apical or basolateral LPS exposure
Differential transcript and soluble factor patterns in macrophage/enterocyte-like monolayer co-cultures based on apical or basolateral LPS exposure Open
Background The monolayer of intestinal epithelial cells (IECs) plays a crucial role in controlling intestinal homeostasis, also by its interaction with the immune system, via paracrine cytokine production, thus driving innate responses by …
View article: Comprehensive assessment of variables affecting Spontaneous Platelet Aggregation in healthy subjects
Comprehensive assessment of variables affecting Spontaneous Platelet Aggregation in healthy subjects Open
Background Platelets in citrate-plasma from some subjects aggregate in light transmission aggregometer (LTA) without stimulation by exogenous agonists ("spontaneous platelet aggregation", SPA). Although SPA was shown to associate with card…
View article: The kinase <scp>LRRK2</scp> is required for the physiological function and expression of the glial glutamate transporter <scp>EAAT2</scp> ( <scp>SLC1A2</scp> )
The kinase <span>LRRK2</span> is required for the physiological function and expression of the glial glutamate transporter <span>EAAT2</span> ( <span>SLC1A2</span> ) Open
Neurotransmitter transporters (NTTs) control synaptic responses by modulating the concentration of neurotransmitters at the synaptic cleft. Glutamate is the most abundant excitatory neurotransmitter in the brain and needs to be finely tune…
View article: Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1) Open
Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various neurological disorders. However, the underlying cellular and molecular mechanisms responsible for its neuroprotective effects remain puzzling. In t…
View article: Bioisosteric analogs of <scp>MDMA</scp> : Improving the pharmacological profile?
Bioisosteric analogs of <span>MDMA</span> : Improving the pharmacological profile? Open
3,4‐Methylenedioxymethamphetamine (MDMA, ‘ ecstasy’ ) is re‐emerging in clinical settings as a candidate for the treatment of specific neuropsychiatric disorders (e.g. post‐traumatic stress disorder) in combination with psychotherapy. MDMA…
View article: A case of acquired transient bleeding diathesis associated with acquired platelet storage pool deficiency and defective thromboxane A2 production
A case of acquired transient bleeding diathesis associated with acquired platelet storage pool deficiency and defective thromboxane A2 production Open
Acquired disorders of platelet function are an underdiagnosed cause of bleeding tendency. A 14-year-old girl developed moderate mucocutaneous bleeding two weeks after a Mycoplasma pneumoniae infection successfully treated with clarithromyc…
View article: Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1) Open
Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various neurological disorders. However, the underlying cellular and molecular mechanisms responsible for its neuroprotective effects remain puzzling. In t…
View article: Bioisosteric analogs of MDMA with improved pharmacological profile
Bioisosteric analogs of MDMA with improved pharmacological profile Open
3,4-Methylenedioxymethamphetamine (MDMA, ‘ ecstasy’ ) is re-emerging in clinical settings as a candidate for the treatment of specific psychiatric disorders (e.g. post-traumatic stress disorder) in combination with psychotherapy. MDMA is a…
View article: Impairment of platelet function in both mild and severe <scp>COVID</scp>‐19 patients
Impairment of platelet function in both mild and severe <span>COVID</span>‐19 patients Open
Summary Abnormalities of platelet function were reported in patients with severe COVID‐19 (severe‐C), but few data are available in patients with mild COVID‐19 (mild‐C) and after COVID‐19 recovery. The aim of this study was to investigate …
View article: The teleost fish PepT1-type peptide transporters and their relationships with neutral and charged substrates
The teleost fish PepT1-type peptide transporters and their relationships with neutral and charged substrates Open
In teleosts, two PepT1-type (Slc15a1) transporters, i.e., PepT1a and PepT1b, are expressed at the intestinal level. They translocate charged di/tripeptides with different efficiency, which depends on the position of the charged amino acid …
View article: Bile acid interactions with neurotransmitter transporters
Bile acid interactions with neurotransmitter transporters Open
Synthesized in the liver from cholesterol, the bile acids (BAs) primary role is emulsifying fats to facilitate their absorption. BAs can cross the blood-brain barrier (BBB) and be synthesized in the brain. Recent evidence suggests a role f…
View article: A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain
A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain Open
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Its homeostasis is maintained by neuronal and glial GABA transporters (GATs). The four GATs identified in humans are GAT1 (SLC6A1), …
View article: Betaine—The dark knight of the brain
Betaine—The dark knight of the brain Open
The role of betaine in the liver and kidney has been well documented, even from the cellular and molecular point of view. Despite literature reporting positive effects of betaine supplementation in Alzheimer's, Parkinson's and schizophreni…
View article: Betaine - the Dark Knight of the brain
Betaine - the Dark Knight of the brain Open
The role of betaine in the liver and kidney has been well documented, even from the cellular and molecular point of view. Despite literature reporting positive effects of betaine supplementation in Alzheimer’s, Parkinson’s, and Schizophren…
View article: The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research
The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research Open
After 50 years, the heterologous expression of proteins in Xenopus laevis oocytes is still essential in many research fields. New approaches and revised protocols, but also classical methods, such as the two-electrode voltage clamp, are ap…
View article: Functional characterization of Atlantic salmon (<i>Salmo salar</i> L.) PepT2 transporters
Functional characterization of Atlantic salmon (<i>Salmo salar</i> L.) PepT2 transporters Open
The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues/organs. Information regarding PepT2 in teleost fish is limit…
View article: Bile Acids Gate Dopamine Transporter Mediated Currents
Bile Acids Gate Dopamine Transporter Mediated Currents Open
Bile acids (BAs) are molecules derived from cholesterol that are involved in dietary fat absorption. New evidence supports an additional role for BAs as regulators of brain function. Sterols such as cholesterol interact with monoamine tran…
View article: Bile acids gate dopamine transporter mediated currents
Bile acids gate dopamine transporter mediated currents Open
Bile acids (BAs) are molecules derived from cholesterol that are involved in dietary fat absorption. New evidence supports an additional role for BAs as regulators of brain function. Interestingly, sterols such as cholesterol interact with…
View article: Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease Open
The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80 % of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events, recycling to the plasma me…
View article: The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters Open
To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotra…
View article: Characterization of Transport Activity of SLC11 Transporters in Xenopus laevis Oocytes by Fluorophore Quenching
Characterization of Transport Activity of SLC11 Transporters in Xenopus laevis Oocytes by Fluorophore Quenching Open
Membrane proteins are involved in different physiological functions and are the target of pharmaceutical and abuse drugs. Xenopus laevis oocytes provide a powerful heterologous expression system for functional studies of these proteins. Ty…
View article: MgSO<sub>4</sub> anticoagulant prevents pseudothrombocytopenia by preserving the integrity of the platelet GPIIb‐IIIa complex
MgSO<sub>4</sub> anticoagulant prevents pseudothrombocytopenia by preserving the integrity of the platelet GPIIb‐IIIa complex Open
Ethylenediaminetetra-acetic acid (EDTA) is the in vitro anticoagulant commonly used to collect blood samples for cell counts.1 One drawback is the development of pseudothrombocytopenia (PTP), a spuriously low platelet count caused by plate…