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View article: Correlates of depressive symptom severity among adults with epilepsy participating in an epilepsy self-management clinical trial
Correlates of depressive symptom severity among adults with epilepsy participating in an epilepsy self-management clinical trial Open
Background People living with epilepsy (PWE) experience higher rates of depression compared with the general population. Depression in PWE is associated with increased seizure burden and reduced quality of life. We aimed to examine clinica…
View article: Association Between Adherence Barriers, Self‐Reported Adherence, and Psychiatric Symptoms Among Adults With Bipolar Disorder
Association Between Adherence Barriers, Self‐Reported Adherence, and Psychiatric Symptoms Among Adults With Bipolar Disorder Open
Aims While suboptimal medication adherence is a widely recognized problem for people with bipolar disorder (BD), it is less clear how individual characteristics are associated with varying levels of adherence and how specific adherence bar…
View article: Addressing implementation challenges in the delivery of an epilepsy self-management program in community settings
Addressing implementation challenges in the delivery of an epilepsy self-management program in community settings Open
There have been 8 nurses (mean age 63.6, SD 9.1) and 14 peer educators trained (mean age 44.3, SD 15.8, having epilepsy a mean of 18.2, SD 11.1 years). Mean number of SMART sessions attended (out of a maximum of 8) was 5.7, SD 2.2. Sample …
View article: Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d’anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d’un échantillon mondial provenant du projet GAGE-BD
Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d’anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d’un échantillon mondial provenant du projet GAGE-BD Open
Background Anticonvulsants are an essential treatment for bipolar disorder; however, there is relatively little known about their use in older age bipolar disorder (OABD). In this paper, which leverages a large international dataset, we ai…
View article: Association Between Symptom Severity and Medication Adherence in Adolescents with Bipolar Disorder Demonstrating Suboptimal Adherence
Association Between Symptom Severity and Medication Adherence in Adolescents with Bipolar Disorder Demonstrating Suboptimal Adherence Open
Objective While medication non-adherence is common in bipolar disorder (BD), few studies have specifically assessed non-adherent BD adolescents and young adults (AYAs). This analysis, using screening and baseline data from an ongoing rando…
View article: Metabolomic and Lipid Alterations are Associated with Longitudinal Neurological Performance in Multiple Sclerosis
Metabolomic and Lipid Alterations are Associated with Longitudinal Neurological Performance in Multiple Sclerosis Open
Metabolomics incorporates information from multiple biological systems and is recognized as an emerging tool for identifying novel multiple sclerosis (MS) biomarkers. While prior studies have linked metabolic alterations to the disease sev…
View article: Harnessing the electronic health record to identify and enroll people with epilepsy into a self-management program: Implementation and scalability in a clinical setting
Harnessing the electronic health record to identify and enroll people with epilepsy into a self-management program: Implementation and scalability in a clinical setting Open
The EXPAND initiative, conducted in 2 Midwest U.S. epilepsy centers, is being successfully implemented to provide ESM to PWE. A widely available EHR has facilitated the referral process and remote delivery format allows for reach among div…
View article: Assessing the Predictive Utility of Quantitative Electroencephalography Coherence in Adolescent Major Depressive Disorder: A Machine Learning Approach
Assessing the Predictive Utility of Quantitative Electroencephalography Coherence in Adolescent Major Depressive Disorder: A Machine Learning Approach Open
Background: Improving early recognition and accurate diagnosis of Major Depressive Disorder (MDD) in childhood is a pressing concern. Quantitative electroencephalogram (qEEG) may be an effective, non-invasive diagnostic biomarker for MDD. …
View article: Targeted and Non-Targeted Metabolomic Evaluation of Cerebrospinal Fluid in Early Phase Schizophrenia: A Pilot Study from the Hopkins First Episode Psychosis Project
Targeted and Non-Targeted Metabolomic Evaluation of Cerebrospinal Fluid in Early Phase Schizophrenia: A Pilot Study from the Hopkins First Episode Psychosis Project Open
(1) Background: The lack of reliable biomarkers remains a significant barrier to improving outcomes for patients with schizophrenia. While metabolomic analyses of blood, urine, and feces have been explored, results have been inconsistent. …
View article: Exploring the early drivers of pain in Parkinson’s disease
Exploring the early drivers of pain in Parkinson’s disease Open
Pain is a common and complex non-motor symptom in people with Parkinson's disease (PWP). Little is known about the genetic drivers of pain in PWP, and progress in its study has been challenging. Here, we conducted two genome-wide associati…
View article: Accelerated Metabolomic Aging and Its Association with Social Determinants of Health in Multiple Sclerosis
Accelerated Metabolomic Aging and Its Association with Social Determinants of Health in Multiple Sclerosis Open
Objectives Biological age may better capture differences in disease course among people with multiple sclerosis (PwMS) of identical chronological age. We investigated biological age acceleration through metabolomic age (mAge) in PwMS and i…
View article: Multiple sclerosis subgroups: Data-driven clusters based on patient-reported outcomes and a large clinical sample
Multiple sclerosis subgroups: Data-driven clusters based on patient-reported outcomes and a large clinical sample Open
Background: While standard clinical assessments provide great value for people with multiple sclerosis (PwMS), they are limited in their ability to characterize patient perspectives and individual-level symptom heterogeneity. Objectives: T…
View article: Clinical correlates of perceived stigma among people living with epilepsy enrolled in a self-management clinical trial
Clinical correlates of perceived stigma among people living with epilepsy enrolled in a self-management clinical trial Open
Perceived epilepsy stigma was positively correlated with depression severity and negatively correlated with social support and self-efficacy. Providers caring for PLWE may help reduce epilepsy stigma by screening for and treating depressio…
View article: Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure
Mobility trajectories in multiple sclerosis: A comparative study of timed 25-foot walk and a patient-reported outcome measure Open
Background: Loss of mobility is common in persons with multiple sclerosis (PwMS), but little is known about this impairment from the patient’s perspective. Objective: The aim is to model longitudinal variation in a mobility patient-reporte…
View article: Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis
Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis Open
Two genetic loci associated with MS AAO were identified, and functional annotation demonstrated an enrichment of genes involved in adaptive and complement immunity. There was also evidence supporting a link with age at puberty and telomere…
View article: A person-centered approach to characterizing longitudinal ambulatory impairment in Parkinson's disease
A person-centered approach to characterizing longitudinal ambulatory impairment in Parkinson's disease Open
Loss of ambulation is common and highly variable in Parkinson’s disease (PD), and poorly understood from the perspectives of those with PD. Gaining insights to the anticipated perceived trajectories and their drivers, will facilitate patie…
View article: Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project Open
Objectives The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symp…
View article: Beta-defensin index: A functional biomarker for oral cancer detection
Beta-defensin index: A functional biomarker for oral cancer detection Open
There is an unmet clinical need for a non-invasive and cost-effective test for oral squamous cell carcinoma (OSCC) that informs clinicians when a biopsy is warranted. Human beta-defensin 3 (hBD-3), an epithelial cell-derived anti-microbial…
View article: Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project Open
Objects Studies of older age bipolar disorder (OABD) have mostly focused on “younger old” individuals. Little is known about the oldest OABD (OOABD) individuals aged ≥70 years old. The Global Aging and Geriatric Experiments in Bipolar Diso…
View article: Prevalence of neuromyelitis optica spectrum disorder in the United States
Prevalence of neuromyelitis optica spectrum disorder in the United States Open
Background: Neuromyelitis optic spectrum disorder (NMOSD) is a rare demyelinating, autoimmune disease and the burden in United States is not well characterized. Objective: The objective of this study was to determine the 2022 US prevalence…
View article: A person-centered approach to characterizing longitudinal ambulatory impairment in Parkinson's disease
A person-centered approach to characterizing longitudinal ambulatory impairment in Parkinson's disease Open
Ambulatory impairment in Parkinson’s disease (PD) is common and complex, and poorly understood from the perspectives of those with PD. Gaining insights to the anticipated perceived trajectories and their drivers, will further facilitate pa…
View article: Common Social and Health Disparities Contribute to Racial Differences in Ambulatory Impairment in Multiple Sclerosis
Common Social and Health Disparities Contribute to Racial Differences in Ambulatory Impairment in Multiple Sclerosis Open
CE INFORMATION ACTIVITY AVAILABLE ONLINE: To access the article and evaluation online, go to https://www.highmarksce.com/mscare. TARGET AUDIENCE: The target audience for this activity is physicians, advanced practice clinicians, nursing pr…