Carlos Maurício Cardeal Mendes
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View article: 60systemically administered oncolytic vaccinia virus enhances the in vivo antitumor effects of rtki and anti-pd-1 based therapies in an immunocompetent renal cancer model
60systemically administered oncolytic vaccinia virus enhances the in vivo antitumor effects of rtki and anti-pd-1 based therapies in an immunocompetent renal cancer model Open
Background While significant advances have been made in the treatment of metastatic renal cell carcinoma (RCC), most patients develop treatment resistance and succumb to progressive disease. Limited options exist for patients checkpoint in…
View article: The Impact of Sensorimotor Training on Physical Fitness in Older Women with Diabetes: A Pilot Study
The Impact of Sensorimotor Training on Physical Fitness in Older Women with Diabetes: A Pilot Study Open
Aging and diabetes mellitus (DM) are associated with declines in physical fitness, including reduced muscle strength, balance, and flexibility, which increase the risk of falls and functional limitations. This pilot study aims to evaluate …
View article: Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise
Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise Open
Saliva was used as non-invasive alternative to blood for diagnosing pathophysiological conditions. This study aimed to assess changes in protein profile in people with obesity after bariatric surgery and to assess the impact of exercise on…
View article: A Framework for Bariatric Surgery Patient Care: Patient and Professional Perceptions
A Framework for Bariatric Surgery Patient Care: Patient and Professional Perceptions Open
Introduction A multidisciplinary health team for perioperative care of the bariatric patient, sustained in a viable framework to support a long-term follow-up service, may decrease rates of complications, help the recognition of the comple…
View article: Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea
Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea Open
Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease.Objective. To diagnose the infectious…
View article: GIS-based approach for optimizing biowaste collection services in rural small sized municipalities
GIS-based approach for optimizing biowaste collection services in rural small sized municipalities Open
Directive (EU) 2018/851 of the European Parliament and of the Council establishes the obligation for Member States to ensure, by 31 December 2023, that biowaste is separated and recycled at source or collected selectively. As this is a res…
View article: Improving snow warning criteria in Portugal with Estrela mountain snow data
Improving snow warning criteria in Portugal with Estrela mountain snow data Open
A major change on the snow warning in Portugal has been implemented in 2019 by the Portuguese meteorological service, resulting from a multidisciplinary approach using data and experience in Estrela mountain, in the centre of the country. …
View article: Simplified vacuum dressing system: operational and financial feasibility study in the management of wounds
Simplified vacuum dressing system: operational and financial feasibility study in the management of wounds Open
Introduction: The high cost of negative pressure wound therapy (NPWT) makes the procedure less accessible in institutions with limited resources. To solve the problem, streamlined vacuum dressings have been proposed, but the usefulness of …
View article: Simplified vacuum dressing system: effectiveness and safety in wounds management
Simplified vacuum dressing system: effectiveness and safety in wounds management Open
SVDM proved to be an effective and acceptably safe device for managing studied wounds.
View article: Adult Users of the Oticon Medical Neuro Cochlear Implant System Benefit from Beamforming in the High Frequencies
Adult Users of the Oticon Medical Neuro Cochlear Implant System Benefit from Beamforming in the High Frequencies Open
The Oticon Medical Neuro cochlear implant system includes the modes Opti Omni and Speech Omni, the latter providing beamforming (i.e., directional selectivity) in the high frequencies. Two studies compared sentence identification scores of…
View article: Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis Open
By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.
View article: Neurophysiological aspects of isotonic exercises in temporomandibular joint dysfunction syndrome
Neurophysiological aspects of isotonic exercises in temporomandibular joint dysfunction syndrome Open
Purpose The aim of the study was to investigate the electroneurophysiological aspects of volunteers with temporomandibular disorders before and after performing isotonic exercises for pain relief and self-care guidelines. Methods The study…
View article: Clinical and epidemiological profile of the mother–neonate binomy with microcefalia and suspected infection by zika viruses in the gestation: a sectional study
Clinical and epidemiological profile of the mother–neonate binomy with microcefalia and suspected infection by zika viruses in the gestation: a sectional study Open
Introduction: The association between the increased incidence of microcephaly and the epidemic outbreak of Zika virus infection (ZIKV) in Brazil between 2015 and 2016 was observed by many authors. World Health Organization declared it as a…
View article: Left ventricular assessment in patients with mucopolysaccharidosis using conventional echocardiography and myocardial deformation by two‐dimensional speckle‐tracking method
Left ventricular assessment in patients with mucopolysaccharidosis using conventional echocardiography and myocardial deformation by two‐dimensional speckle‐tracking method Open
Objective: Mucopolysaccharidosis is a rare genetic disease characterized by the intralysosomal deposition of glycosaminoglycans. Cardiovascular impairment is a common feature. Cardiac signs and symptoms are underestimated due to the diseas…
View article: Supplementary Material for: Functional Characterization and Pharmacological Evaluation of a Novel <b><i>GLA</i></b> Missense Mutation Found in a Severely Affected Fabry Disease Family
Supplementary Material for: Functional Characterization and Pharmacological Evaluation of a Novel <b><i>GLA</i></b> Missense Mutation Found in a Severely Affected Fabry Disease Family Open
Background: Fabry disease (FD) is a rare X-linked storage disorder resulting from the deficient activity of the lysosomal hydrolase α-galactosidase A (α-Gal A). Here we describe a 23-year-old man with FD possessing a novel mutation in the …
View article: Bone mineral density and inflammatory bowel disease severity
Bone mineral density and inflammatory bowel disease severity Open
Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classificatio…
View article: Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity
Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity Open
Objectives Iodine deficiency disorder (IDD) is the result of an inadequate dietary intake of iodine, which physiological consequences are endemic goiter and thyroid dysfunction. The objective of this study was to a analyze studies that ass…
View article: Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study
Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study Open
Background: Congenital heart diseases are the most common type of congenital defects, and account for more deaths in the first year of life than any other condition, when infectious etiologies are ruled out. Objectives: To evaluate surviva…
View article: Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study
Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study Open
Background: Congenital heart diseases are the most common type of congenital defects, and account for more deaths in the first year of life than any other condition, when infectious etiologies are ruled out. Objectives: To evaluate surviva…
View article: Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study
Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study Open
Preterm infants with low birth weight and comorbidities presented a higher risk of mortality related to congenital heart diseases. This cohort was extinguished very quickly, signaling the need for greater investment in assistance technolog…
View article: Bone mineral density and inflammatory bowel disease severity
Bone mineral density and inflammatory bowel disease severity Open
Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classificatio…
View article: Common mental disorders in medical students: A repeated cross-sectional study over six years
Common mental disorders in medical students: A repeated cross-sectional study over six years Open
Summary Introduction: Becoming a medical doctor is a very complex process. Factors related to the student’s personality, the educational process and the daily experience with death contribute to peculiar psycho-emotional experiences, not a…