Francis K.L. Chan
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View article: MOMMY study profile: An integrative early‐life multi‐omics cohort in China
MOMMY study profile: An integrative early‐life multi‐omics cohort in China Open
Large‐scale, prospective birth cohorts capturing the complex interplay between the gut microbiome, host biology, and environmental exposures are crucial to understanding early‐life health but remain scarce, particularly within Asian popula…
View article: The Mediating Role of Eating Behaviors Between Autistic Symptoms and Dietary Issues Among Chinese Children With Autism
The Mediating Role of Eating Behaviors Between Autistic Symptoms and Dietary Issues Among Chinese Children With Autism Open
Purpose Eating and dietary challenges are common among children with autism, but their associations with clinical symptoms remain unclear. This study aims to describe dietary issues, including nutritional problems and overexposures to food…
View article: Discovery and characterization of Christensenella hongkongensis as a novel bacterium in the adenoma-carcinoma progression
Discovery and characterization of Christensenella hongkongensis as a novel bacterium in the adenoma-carcinoma progression Open
Background Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and commonly starts from a pre-cancerous stage. This study aimed to identify potential fecal bacterial candidates associated with progression of CRC fro…
View article: Impact of dietary emulsifiers on the presence of adherent-invasive Escherichia coli in Crohn’s disease
Impact of dietary emulsifiers on the presence of adherent-invasive Escherichia coli in Crohn’s disease Open
Adherent-invasive Escherichia coli (AIEC) has been implicated in Crohn’s disease (CD) pathogenesis. We aimed to evaluate the impact of dietary factors on the presence of AIEC in patients with CD and to identify AIEC-associated mucosa…
View article: Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong
Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong Open
The implementation of a lung nodule surveillance programme resulted in the detection of early-stage lung cancer in more than half of diagnosed cases, with the potential to improve patient survival.
View article: The Role of Gut Microbiota in Insomnia: A Systematic Review of Case–Control Studies
The Role of Gut Microbiota in Insomnia: A Systematic Review of Case–Control Studies Open
Background: Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota’s role in sleep regulation through the gut–brain axis. This syst…
View article: Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus
Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus Open
Microbiotherapy has opened new avenues for managing dysbiosis‐related diseases. However, many studies did not cover all the necessary reporting items for microbiotherapy making the interpretation of results, safety assessment, technology e…
View article: <i>Roseburia hominis</i> improves host metabolism in diet-induced obesity
<i>Roseburia hominis</i> improves host metabolism in diet-induced obesity Open
Next-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples of obese subjects …
View article: Early‐life antibiotic exposure aggravates hepatic steatosis through enhanced endotoxemia and lipotoxic effects driven by gut <i>Parabacteroides</i>
Early‐life antibiotic exposure aggravates hepatic steatosis through enhanced endotoxemia and lipotoxic effects driven by gut <i>Parabacteroides</i> Open
Compelling evidence supports a link between early‐life gut microbiota and the metabolic outcomes in later life. Using an early‐life antibiotic exposure model in BALB/c mice, we investigated the life‐course impact of prenatal and/or postnat…
View article: Long‐term use of low‐dose aspirin for cancer prevention: A 20‐year longitudinal cohort study of 1,506,525 Hong Kong residents
Long‐term use of low‐dose aspirin for cancer prevention: A 20‐year longitudinal cohort study of 1,506,525 Hong Kong residents Open
Long‐term use of low‐dose aspirin has been demonstrated to reduce cancer risk, but the duration of necessary medication use remains uncertain. This study aimed to investigate the long‐term chemoprotective effect of aspirin among the Chines…
View article: Impacts of COVID-19 pandemic on early life gut microbiome
Impacts of COVID-19 pandemic on early life gut microbiome Open
Increased hygiene and sanitation are theorized to predispose to developing atopic diseases, a process potentially mediated by the gut microbiome. We hypothesized that the gut microbiome maturation has been altered by COVID-19 lockdown meas…
View article: The Long‐Term Risk of Metachronous Advanced Adenoma Recurrence After Endoscopic Submucosal Dissection for Colorectal Neoplasia: A Propensity‐Score Matched Longitudinal Cohort With 5‐Year Follow‐Up
The Long‐Term Risk of Metachronous Advanced Adenoma Recurrence After Endoscopic Submucosal Dissection for Colorectal Neoplasia: A Propensity‐Score Matched Longitudinal Cohort With 5‐Year Follow‐Up Open
Introduction Long‐term data on metachronous advanced adenoma (AA) recurrence after endoscopic submucosal dissection (ESD) remain scarce, leading to a lack of a standardized surveillance strategy. This study aims to evaluate the long‐term r…
View article: Variation in the metagenomic analysis of fecal microbiome composition calls for a standardized operating approach
Variation in the metagenomic analysis of fecal microbiome composition calls for a standardized operating approach Open
The reproducibility in microbiome studies is limited due to the lack of one gold-standard operating procedure. The aim of this study was to examine the impact of protocol variations on microbiome composition using metagenomic data sets fro…
View article: Fecal microbial marker panel for aiding diagnosis of autism spectrum disorders
Fecal microbial marker panel for aiding diagnosis of autism spectrum disorders Open
Accumulating evidence suggests that gut microbiota alterations influence brain function and could serve as diagnostic biomarkers and therapeutic targets. The potential of using fecal microbiota signatures to aid autism spectrum disorder (A…
View article: Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis Open
Objective The specific breast milk-derived metabolites that mediate host–microbiota interactions and contribute to the onset of atopic dermatitis (AD) remain unknown and require further investigation. Design We enrolled 250 mother–infant p…
View article: Gut mycobiome alterations in obesity in geographically different regions
Gut mycobiome alterations in obesity in geographically different regions Open
The gut fungi play important roles in human health and are involved in energy metabolism. This study aimed to examine gut mycobiome composition in obese subjects in two geographically different regions in China and to identify specific gut…
View article: Driving cross-sector synergies through holistic building decarbonization in Hong Kong – AIRSIDE: a landmark grade A office & retail development
Driving cross-sector synergies through holistic building decarbonization in Hong Kong – AIRSIDE: a landmark grade A office & retail development Open
This paper examines how a collaborative and holistic design and operation framework can drive building decarbonization through case study. In Hong Kong’s evolving real estate landscape, developers of new commercial developments are strivin…
View article: Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity
Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity Open
Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is understudied. We included 1,592 infants from the …
View article: Dietary habits and physical activity during the third wave of the COVID-19 pandemic: associated factors, composite outcomes in a cross-sectional telephone survey of a Chinese population, and trend analysis
Dietary habits and physical activity during the third wave of the COVID-19 pandemic: associated factors, composite outcomes in a cross-sectional telephone survey of a Chinese population, and trend analysis Open
Prevalences of unhealthy lifestyle habits were high among men, single individuals, and chronic disease patients during the third wave of the COVID-19 pandemic in Hong Kong. The adoption of physical activity habits tended to decrease in the…
View article: Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder
Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder Open
Emerging evidence suggests autism spectrum disorder (ASD) is associated with altered gut bacteria. However, less is known about the gut viral community and its role in shaping microbiota in neurodevelopmental disorders. Herein, we perform …