Colm P. O’Donnell
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View article: A decade of aeromedical care for the older adult: a 10-year review of Irish HEMS cases in patients aged 65 and over
A decade of aeromedical care for the older adult: a 10-year review of Irish HEMS cases in patients aged 65 and over Open
Older adults represent a significant proportion of HEMS activity in Ireland. While HEMS plays an important role in facilitating access to emergency care for this group, particularly in rural areas, patterns in dispatch, transport decisions…
View article: Co-designing accessible and inclusive patient information resources for gastrointestinal endoscopy using Patient and Public Involvement (PPI) and Universal Design for Learning (UDL) principles
Co-designing accessible and inclusive patient information resources for gastrointestinal endoscopy using Patient and Public Involvement (PPI) and Universal Design for Learning (UDL) principles Open
Co-designing accessible and inclusive patient information resources for gastrointestinal endoscopy using Patient and Public Involvement (PPI) and Universal Design for Learning (UDL) Principles. Introduction Patients undergoing GI endoscopy…
View article: Patient and mission characteristics of helicopter emergency medical services in the Republic of Ireland: a retrospective analysis
Patient and mission characteristics of helicopter emergency medical services in the Republic of Ireland: a retrospective analysis Open
Over the past decade, HEMS in Ireland has provided a valuable contribution to the care of seriously ill and injured patients, particularly in the west and southwest. Service use reflects HEMS base proximity, indicating potential benefits f…
View article: Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes
Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes Open
Protocol (2004): doi.org/10.1002/14651858.CD004953 Original review (2015): doi.org/10.1002/14651858.CD004953.pub2 Review update (2017): doi.org/10.1002/14651858.CD004953.pub3 Review update (2020): doi.org/10.1002/14651858.CD004953.pub4.
View article: Assessing microplastic contamination in milk and dairy products
Assessing microplastic contamination in milk and dairy products Open
The presence of microplastics in food has raised growing concern due to potential health risks. While many studies have investigated microplastics in water and seafood, limited data are available for dairy products. This study qualitativel…
View article: Probing the Turbulent Corona and Heliosphere Using Radio Spectral Imaging Observation during the Solar Conjunction of Crab Nebula
Probing the Turbulent Corona and Heliosphere Using Radio Spectral Imaging Observation during the Solar Conjunction of Crab Nebula Open
Measuring plasma parameters in the upper solar corona and inner heliosphere is challenging because of the region's weakly emissive nature and inaccessibility for most in situ observations. Radio imaging of broadened and distorted backgroun…
View article: Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases
Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases Open
Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality i…
View article: Investigation of Biological Activity of Fucoidan and Laminarin as Bioactive Polysaccharides from Irish Brown Macroalgae
Investigation of Biological Activity of Fucoidan and Laminarin as Bioactive Polysaccharides from Irish Brown Macroalgae Open
This study aimed to investigate the biological activity of crude and purified laminarin and fucoidan samples extracted from Irish brown macroalgae species Laminaria digitata and Fucus vesiculosus. The antioxidant capacity of the samples wa…
View article: Using PPI and UDL principles to design a gastrointestinal endoscopy patient information video series
Using PPI and UDL principles to design a gastrointestinal endoscopy patient information video series Open
Introduction Patients undergoing GI endoscopy often experience anxiety and due to limited health literacy. Traditional paper-based information leaflets are often not sufficient to accommodate for the diverse way in which people consume inf…
View article: Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models
Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models Open
Dysregulation of master regulator c-MYC (MYC) plays a central role in hepatocellular carcinoma (HCC) and other cancers but remains an elusive target for therapeutic intervention. MYC expression is epigenetically modulated within naturally …
View article: Harmonizing the healing of hand trauma in a piano teacher: a case report on pain management in Ireland and utilizing butterfly ultrasound for a brachial plexus nerve block
Harmonizing the healing of hand trauma in a piano teacher: a case report on pain management in Ireland and utilizing butterfly ultrasound for a brachial plexus nerve block Open
Background: This case report outlined a specialized surgical technique designed for the restoration of intricate hand functionality after a complex hand injury. It also highlighted the use of Butterfly iQ+ and its integration with iOS devi…
View article: The emergence of nitazenes on the Irish heroin market and national preparation for possible future outbreaks
The emergence of nitazenes on the Irish heroin market and national preparation for possible future outbreaks Open
On 9 November 2023, the Health Service Executive Ireland (HSE) was notified of an unusually high pattern of opioid overdoses occurring in Dublin city centre among people attending homeless services. This represented the very early signs of…
View article: Impact of variation of the cooling system operating strategy on energy efficiency and waste heat quality: a preliminary investigation on a hybrid-cooled data centre
Impact of variation of the cooling system operating strategy on energy efficiency and waste heat quality: a preliminary investigation on a hybrid-cooled data centre Open
The growing demand for digital services is leading to a rapid increase of the number of data centres worldwide. Because of the large amount of energy required to power these facilities and the consequent challenges for the energy system an…
View article: Maternal Graves Disease Postthyroidectomy With Fetal Thyrotoxicosis and Goiter
Maternal Graves Disease Postthyroidectomy With Fetal Thyrotoxicosis and Goiter Open
Fetal thyrotoxicosis is a rare condition with high morbidity and mortality. It may complicate pregnancies in women with a history of Graves disease (GD) when transplacental passage of maternal TSH receptor antibodies stimulate the fetal th…
View article: Temporal trends of ambulance time intervals for suspected stroke/transient ischaemic attack (TIA) before and during the COVID-19 pandemic in Ireland: a quasi-experimental study
Temporal trends of ambulance time intervals for suspected stroke/transient ischaemic attack (TIA) before and during the COVID-19 pandemic in Ireland: a quasi-experimental study Open
Objectives Time is a fundamental component of acute stroke and transient ischaemic attack (TIA) care, thus minimising prehospital delays is a crucial part of the stroke chain of survival. COVID-19 restrictions were introduced in Ireland in…
View article: Investigating the accuracy and comparability of various lime prediction methods for Irish grassland mineral soils
Investigating the accuracy and comparability of various lime prediction methods for Irish grassland mineral soils Open
Soil pH is a foundational element of agronomy, profoundly influencing biological, chemical and physical soil processes. Adjusting soil pH is a paramount factor for enhancing soil health and productivity with far‐reaching environmental bene…
View article: Nasal interfaces for neonatal resuscitation
Nasal interfaces for neonatal resuscitation Open
Nasal interfaces were found to offer comparable efficacy to face masks (low- to very low-certainty evidence), supporting resuscitation guidelines that state that nasal interfaces are a comparable alternative to face masks for providing res…
View article: 782 Tranexamic Acid Administration for Blood Loss in High-Tibial Osteotomy (HTO): A Systematic Review and Meta-Analysis
782 Tranexamic Acid Administration for Blood Loss in High-Tibial Osteotomy (HTO): A Systematic Review and Meta-Analysis Open
Aim To evaluate clinical outcomes after tranexamic acid (TXA) administration with the aim of reducing blood loss during and after high-tibial osteotomy (HTO) with available clinical evidence. Method Systematic search methodology of PUBMED,…
View article: Extraction yield and biological activity of phycobiliproteins from Porphyridium purpureum using atmospheric cold plasma discharge and jet systems
Extraction yield and biological activity of phycobiliproteins from Porphyridium purpureum using atmospheric cold plasma discharge and jet systems Open
Phycobiliproteins (PBPs) extracted from Porphyridium purpureum (P.p) have bioactive properties and are widely used as ingredients in nutraceutical and food applications. This study investigated the use of two cold plasma systems, namely co…
View article: Oral stimulation for promoting oral feeding in preterm infants
Oral stimulation for promoting oral feeding in preterm infants Open
There remains uncertainty about the effects of oral stimulation (versus either standard care or a non-oral intervention) on transition times to oral feeding, duration of intensive care stay, hospital stay, or exposure to parenteral nutriti…
View article: Effects of the COVID-19 Pandemic on Prehospital Emergency Care for Adults with Stroke and Transient Ischaemic Attack: A Systematic Review and Meta-Analysis
Effects of the COVID-19 Pandemic on Prehospital Emergency Care for Adults with Stroke and Transient Ischaemic Attack: A Systematic Review and Meta-Analysis Open
Our review indicates that prehospital delays for suspected stroke/TIA increased during the COVID-19 pandemic. Furthermore, emergency call volume for suspected stroke/TIA decreased during this period. In order to minimize delays in future p…
View article: The Implementation and Evolution of Helicopter Emergency Medical Services in the Republic of Ireland
The Implementation and Evolution of Helicopter Emergency Medical Services in the Republic of Ireland Open
Introduction: Helicopter Emergency Medical Services (HEMS) have formed an integral component of the Irish healthcare system for the past decade, yet the factors leading its commencement, its evolutions over this time, the current model of …