Fawaz Aldabbagh
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View article: Nucleoside Analogues for Chagas Disease and Leishmaniasis Therapy: Current Status and Future Perspectives
Nucleoside Analogues for Chagas Disease and Leishmaniasis Therapy: Current Status and Future Perspectives Open
Chagas disease and leishmaniasis are two neglected tropical diseases that affect millions of people in low- and middle-income tropical countries. These diseases caused by protozoan parasites pose significant global health challenges, which…
View article: OPTIMIZING MEDIA STERILIZATION VIA CHLORINE DIOXIDE AND AUTOCLAVING OF PAULOWNI MICROPROPAGATION
OPTIMIZING MEDIA STERILIZATION VIA CHLORINE DIOXIDE AND AUTOCLAVING OF PAULOWNI MICROPROPAGATION Open
This study was aimed to investigat integrated system for in vitro growth of paulownia plants by assessing the efficacy of chlorine dioxide (ClO2) as an alternative to autoclave in sterilizing culture medium. Therefore, this study was devis…
View article: 1-(2,5-Dimethoxy-4-nitrophenyl)piperidine
1-(2,5-Dimethoxy-4-nitrophenyl)piperidine Open
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield. Yield…
View article: 1-(2,5-Dimethoxy-4-nitrophenyl)piperidine and 1-(2,5-dimethoxy-4-nitrophenyl)pyrroridine
1-(2,5-Dimethoxy-4-nitrophenyl)piperidine and 1-(2,5-dimethoxy-4-nitrophenyl)pyrroridine Open
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine, led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield. Yiel…
View article: Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis Open
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of th…
View article: Heterocyclic Iminoquinones and Quinones from National Cancer Institute (NCI, USA) COMPARE Analysis
Heterocyclic Iminoquinones and Quinones from National Cancer Institute (NCI, USA) COMPARE Analysis Open
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition across the 60-cell line panel of the NCI Dev…
View article: Lactate and glucose induced self‐assembly of hydrophobic boronic acid‐substituted polymers
Lactate and glucose induced self‐assembly of hydrophobic boronic acid‐substituted polymers Open
Amphiphilic boronic acid (BA)‐substituted block copolymers have been utilized in biomedical applications through binding to saccharides, including to glucose whereas binding to the anaerobically produced metabolite lactate is unreported. G…
View article: Lactate and glucose responsive boronic acid-substituted amphiphilic block copolymer nanoparticles of high aspect ratio
Lactate and glucose responsive boronic acid-substituted amphiphilic block copolymer nanoparticles of high aspect ratio Open
The establishment of conditions for formation of higher order morphologies (e.g. rods and worms) is important, as such nanoparticles are more efficient than spheres in drug delivery. Glucose-binding of core–shell nanoparticles comprising o…
View article: RAFT dispersion polymerization induced self-assembly (PISA) of boronic acid-substituted acrylamides
RAFT dispersion polymerization induced self-assembly (PISA) of boronic acid-substituted acrylamides Open
For the unprotected monomer, the boroxine core of nanoparticles allows transitions to higher order morphologies, while worms and vesicles are yielded directly from PISA of the pinacol ester-protected monomer.
View article: CF3-Bis-TEMPO-Vis: New Visible Light Active Bis-Benzimidazolequinone Alkoxyamine
CF3-Bis-TEMPO-Vis: New Visible Light Active Bis-Benzimidazolequinone Alkoxyamine Open
Alkoxyamines of TEMPO usually dissociate thermally at >100 °C; however, room temperature homolysis, activated by visible light, occurs with benzimidazolequinone derivatives. 1,1’-Dimethyl-2,2’-bis{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]me…
View article: Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles
Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles Open
This review article provides a perspective on the synthesis of alicyclic and heterocyclic ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles, and imidazo[5,4-f]benzimidazoles. These heterocycles have a plethora of biological activitie…
View article: Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone
Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone Open
A new one-pot electrophilic chlorination and bromination with oxidative demethylation uses harmless and inexpensive sodium chloride and sodium bromide with Oxone to yield alicyclic ring-fused bis-benzimidazolequinones.
View article: The reactivity of Oxone towards 4,6-di(cycloamino)-1,3-phenylenediamines: synthesis of spirocyclic oxetane ring-fused imidazobenzimidazoles
The reactivity of Oxone towards 4,6-di(cycloamino)-1,3-phenylenediamines: synthesis of spirocyclic oxetane ring-fused imidazobenzimidazoles Open
Spirocyclic oxetane ring-fused imidazo[4,5-f]benzimidazole and imidazo [5,4-f]benzimidazole are reported.Oxone-mediated ring-closures to give imidazobenzimidazoles require acid and the functionalization of the 4,6di(cycloamino)-1,3-phenyle…
View article: 2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole
2-(Fluoromethyl)-4,7-dimethoxy-1-methyl-1H-benzimidazole Open
Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)) substitutes the TEMPO free radical with fluorine on 4,7-dimethoxy-1-methyl-2-{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-1H-benzimidazole to…
View article: 6-Imino-1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1′,2′:1,2]imidazo[4,5-f]benzimidazole-13-one: Synthesis and Cytotoxicity Evaluation
6-Imino-1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1′,2′:1,2]imidazo[4,5-f]benzimidazole-13-one: Synthesis and Cytotoxicity Evaluation Open
The first report of an iminoquinone of imidazo[4,5-f]benzimidazole is described. The 2D-NOESY spectrum of 1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1’,2’:1,2]imidazo[4,5-f]benzimidazol-6-amine was used to confirm the location of the i…
View article: Correction: Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines
Correction: Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines Open
Correction for ‘Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines’ by Patrick Kielty et al., Chem. Commun., 2019, 55, 14665–14668, DOI: 10.1039/C9CC08261A.
View article: CCDC 1917886: Experimental Crystal Structure Determination
CCDC 1917886: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1917885: Experimental Crystal Structure Determination
CCDC 1917885: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Regioselective Fluorination of 7-Oxo-1,2,4-benzotriazines Using Selectfluor
Regioselective Fluorination of 7-Oxo-1,2,4-benzotriazines Using Selectfluor Open
7-Oxo-1,2,4-benzotriazines (benzo[1,2,4]triazin-7-ones) are reversible thioredoxin reductase inhibitors that exhibit very strong correlations to pleurotin. In this article, we provide the first synthesis of fluorinated derivatives. Fluorin…
View article: Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines
Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines Open
Controllable room-temperature visible-light activated nitroxide (TEMPO)-release from benzimidazolequinone alkoxyamines and bis-alkoxyamines.
View article: Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors
Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors Open
Cell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free radicals were se…
View article: 1-Fluoro-2,5-dimethoxy-4-nitrobenzene
1-Fluoro-2,5-dimethoxy-4-nitrobenzene Open
1-Fluoro-2,5-dimethoxy-4-nitrobenzene was synthesized in 90% yield by the reaction of commercial 2-fluoro-1,4-dimethoxybenzene with nitric acid. The structure was confirmed by X-ray crystallography. The new title compound was characterized…
View article: Radical Polymerization of Alkyl 2-Cyanoacrylates
Radical Polymerization of Alkyl 2-Cyanoacrylates Open
Cyanoacrylates (CAs) are well-known fast-setting adhesives, which are sold as liquids in the presence of stabilizers. Rapid anionic polymerization on exposure to surface moisture is responsible for instant adhesion. The more difficult, but…
View article: CCDC 1819144: Experimental Crystal Structure Determination
CCDC 1819144: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …