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View article: Characterization of a human monoclonal autoantibody directed to cardiolipin/β2 glycoprotein I produced by chronic lymphocytic leukaemia B cells
Characterization of a human monoclonal autoantibody directed to cardiolipin/β2 glycoprotein I produced by chronic lymphocytic leukaemia B cells Open
SUMMARY We determined the specificity and sequence of immunoglobulin molecules synthesized by monoclonal B cells from a patient with chronic lymphocytic leukaemia (CLL) who presented with a number of clinical and biological autoimmune symp…
View article: Frequency of central lesions in polyneuropathy associated with IgM monoclonal gammopathy: an MRI, neurophysiological and immunochemical study.
Frequency of central lesions in polyneuropathy associated with IgM monoclonal gammopathy: an MRI, neurophysiological and immunochemical study. Open
CNS lesions were studied in polyneuropathy associated with IgM monoclonal gammopathy. Eleven out of 12 patients with IgM MGUS and one patient with Waldenstrom's disease had clinical and electrophysiological features indicating a demyelinat…
View article: Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency
Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency Open
SUMMARY Striking variations of serum immunoglobulin class and IgG subclass levels were observed in five patients with common variable immunodeficiency. They occurred mainly in untreated patients or, in those patients who received substitut…
View article: Reactivity of human monoclonal IgM with nerve glycosphingolipids
Reactivity of human monoclonal IgM with nerve glycosphingolipids Open
SUMMARY We examined the reactivity of monoclonal IgM of sera from patients with neuropathy and monoclonal IgM, with or without antibody activity to myelin-associated glycoprotein (MAG), as well as sera from non-neurologic patients with Wal…
View article: Autoantibodies to 200 kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis.
Autoantibodies to 200 kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis. Open
Fifty sera which gave ring-like nuclear staining in immunofluorescence on rat liver tissue sections were characterized. Using immunoprecipitation and Western blotting we showed that 10 of the sera contained antibodies to 200 kD polypeptide…
View article: Necrobiotic xanthogranuloma with myeloma. A case report
Necrobiotic xanthogranuloma with myeloma. A case report Open
Necrobiotic xanthogranuloma is a newly recognized cutaneous manifestation associated with paraproteinemia. Necrobiotic xanthogranuloma is distinctive clinically by yellowish-red nodular lesions, often ulcerated, with predilection for the p…
View article: Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome.
Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome. Open
Serum IgG subclass levels were measured by an indirect competitive immunoenzymatic assay with monoclonal antibodies in 61 adult patients of different geographic origins affected either with the lymphoadenopathy syndrome (LAS, 46 cases) or …
View article: Characterization of a human monoclonal IgM with antibody activity to dsDNA.
Characterization of a human monoclonal IgM with antibody activity to dsDNA. Open
We report here the characterization and fine specificity of a human monoclonal IgM lambda reacting with double stranded DNA. The purified IgM and its Fab fragment bind to DNA in the Farr or Crithidia lucilae assays as well as in an immunoe…
View article: Cryoprecipitation of an anti-Pr2 monoclonal IgM cold agglutinin in the presence of GM3 ganglioside.
Cryoprecipitation of an anti-Pr2 monoclonal IgM cold agglutinin in the presence of GM3 ganglioside. Open
The mechanism of cryoprecipitation of a monoclonal IgM kappa cryoglobulin (Mou) with a cold agglutinin activity of Pr2 specificity has been studied. By immunodiffusion this cryoglobulin reacted (by its Fab' fragment) with micellar GM3, a g…
View article: Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations
Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations Open
Six hundred and twelve monoclonal Ig (MIg) were studied for their antibody activity against the following autoantigens: actin, tubulin, thyroglobulin, myosin, myoglobin, fetuin, albumin, transferrin, and double-stranded DNA (dsDNA). Of the…
View article: Extramedullary plasmacytoma with gastric and lymph node involvement: An immunological study
Extramedullary plasmacytoma with gastric and lymph node involvement: An immunological study Open
A case of gastric and lymph node extramedullary plasmacytoma is reported in a young Algerian female. Treatment with cyclophosphamide was ineffective, but rubidazone, followed by a maintenance therapy with prednisone, procarbazine, and vinb…
View article: Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy.
Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy. Open
The monoclonal immunoglobulin (Ig)M from 5 to 16 patients with Waldenström's macroglobulinemia and a polyneuropathy shared cross-idiotypic antigenic determinants as demonstrated by hemagglutination and hemagglutination inhibition experimen…
View article: Gamma heavy chain disease simulating alpha chain disease.
Gamma heavy chain disease simulating alpha chain disease. Open
A young Turkish girl presented with all the clinicopathological features of a digestive form of alpha chain disease. A gamma heavy chain disease protein, however, was found in her serum and also in the cells invading the intestinal mucosa …
View article: Intracytoplasmic and surface-bound immunoglobulins in "nonsecretory" and Bence-Jones myeloma.
Intracytoplasmic and surface-bound immunoglobulins in "nonsecretory" and Bence-Jones myeloma. Open
Immunoglobulins were studied at the cellular level by direct immunofluorescence in twenty-five patients with 'nonsecretory' myeloma and thirty-six patiens with Bence-Jones (BJ) myeloma. The results were compared with those obtained in a co…
View article: MU-Chain Disease in an African Patient
MU-Chain Disease in an African Patient Open
A new case of µ-chain disease occurring in an African patient is described. The main clinical feature was a massive splenomegaly. Contrary to five previously reported cases, this patient was not affected with chronic lymphocytic leukemia, …
View article: Serum monoclonal immunoglobulins in childhood
Serum monoclonal immunoglobulins in childhood Open
Of 18 children with monoclonal immunoglobulins in their sera, 13 had a primary or secondary immunodeficiency. The monoclonal immunoglobulin belonged to each of the three main Ig classes, and in 3 children multiple monoclonal components wer…
View article: Natural history of monoclonal immunoglobulins.
Natural history of monoclonal immunoglobulins. Open
the major prolongation is in the Gi phase of the cell cycle.When nutritional limitations on growth are overcome evidence is obtained that crowding and contact inhibition as well as soluble metabolic factors may contribute to the limitation…
View article: Book Reviews
Book Reviews Open
This booklet contains the reports of a Symposium held on November 28th, 1966, under the chairmanship of F. Avery Jones.Only three items of post-gastrectomy nutrition arc concerned here: anaemia, calcium metabolism and the result of vago to…