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View article: Late onset Alzheimer’s Disease mouse model with altered synaptic and behavior phenotypes
Late onset Alzheimer’s Disease mouse model with altered synaptic and behavior phenotypes Open
Background Genetically modified mouse models have provided a vital understanding of the Alzheimer’s disease (AD) mechanisms, but these models were generally focused on familial AD and do not recapitulate the late‐onset human AD pathophysio…
View article: Alzheimer’s disease and other memory disorders in the age of AI: reflection and perspectives on the 120th anniversary of the birth of Dr. John von Neumann
Alzheimer’s disease and other memory disorders in the age of AI: reflection and perspectives on the 120th anniversary of the birth of Dr. John von Neumann Open
View article: Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms
Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms Open
View article: Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated with Alzheimer’s Disease
Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated with Alzheimer’s Disease Open
Oxidative stress and blood-brain barrier (BBB) disruption due to brain endothelial barrier dysfunction contribute to Alzheimer’s Disease (AD), which is characterized by beta-amyloid (Aβ) accumulation in senile plaques. Copper (Cu) is impli…
View article: Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia Open
View article: Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology
Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology Open
Aging is a major risk factor for multiple chronic disorders in the elderly population, including Alzheimer's disease (AD) and Osteoporosis. AD is a progressive neurodegenerative disease characterized by memory loss. In addition to dementia…
View article: EFFECTS OF SYNTAXIN BINDING PROTEIN-1 MUTATIONS IN NEURONAL NETWORK ACTIVITY AND SYNAPTIC FUNCTION
EFFECTS OF SYNTAXIN BINDING PROTEIN-1 MUTATIONS IN NEURONAL NETWORK ACTIVITY AND SYNAPTIC FUNCTION Open
View article: CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome Open
Microinjected transgenes, both large and small, are known to insert randomly into the mouse genome. Traditional methods of mapping a transgene are challenging, thus complicating breeding strategies and accurate interpretation of phenotypes…
View article: W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34 Open
View article: W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34 Open
Spinocerebellar ataxias (SCA) are a group of neurodegenerative disorders caused by a number of different mutations the leads to loss of motor coordination with characteristic ages of onset, symptomatology, and rates of progression. SCA typ…
View article: W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34 Open
Background: Spinocerebellar ataxias (SCA) are a group of neurodegenerative disorders characterized by neuronal degeneration leading to loss of motor coordination. A number of different mutations gives rise to different types of SCA with ch…
View article: Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations Open
Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL family of fatty acid elongases that is collectively responsible for catalyzing formation of long chain fatty acids. ELOVL4 is the only family member that…
View article: Age-related cognitive impairment: Role of reduced Synaptobrevin-2 levels in the decline of learning and memory and changes in neurotransmission
Age-related cognitive impairment: Role of reduced Synaptobrevin-2 levels in the decline of learning and memory and changes in neurotransmission Open
View article: Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain
Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain Open
View article: Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity
Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity Open
Cognitive impairment in the aging population is quickly becoming a health care priority, for which currently no disease-modifying treatment is available. Multiple domains of cognition decline with age even in the absence of neurodegenerati…
View article: Syndecan‐4 influences mammalian myoblast proliferation by modulating myostatin signalling and G1/S transition
Syndecan‐4 influences mammalian myoblast proliferation by modulating myostatin signalling and G1/S transition Open
Myostatin, a TGF ‐β superfamily member, is a negative regulator of muscle growth. Here we describe how myostatin activity is regulated by syndecan‐4, a ubiquitous transmembrane heparan sulfate proteoglycan. During muscle regeneration the l…
View article: Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency Open
View article: Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype Open
Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation, which comprom…
View article: Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment
Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment Open
View article: Distribution of ELOVL4 in the Developing and Adult Mouse Brain
Distribution of ELOVL4 in the Developing and Adult Mouse Brain Open
ELOngation of Very Long chain fatty acids (ELOVL)-4 is essential for the synthesis of very long chain-fatty acids (fatty acids with chain lengths ≥ 28 carbons). The functions of ELOVL4 and its very long-chain fatty acid products are poorly…
View article: Myostatin propeptide mutation of the hypermuscular<i>Compact</i>mice decreases the formation of myostatin and improves insulin sensitivity
Myostatin propeptide mutation of the hypermuscular<i>Compact</i>mice decreases the formation of myostatin and improves insulin sensitivity Open
The TGFβ family member myostatin (growth/differentiation factor-8) is a negative regulator of skeletal muscle growth. The hypermuscular Compact mice carry the 12-bp Mstn(Cmpt-dl1Abc) deletion in the sequence encoding the propeptide region …
View article: Memory loss
Memory loss Open
New causes of memory loss are still being identified. More sophisticated diagnostic tools have improved our ability to make earlier diagnoses in older adults with memory loss.
View article: Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment
Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment Open
As the population of the Western world is aging, there is increasing awareness of age-related impairments in cognitive function and a rising interest in finding novel approaches to preserve cerebral health. A special collection of articles…
View article: Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility Open
View article: Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice
Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice Open
There is increasing evidence that vascular risk factors, including aging, hypertension, diabetes mellitus, and obesity, promote cognitive impairment; however, the underlying mechanisms remain obscure. Cerebral blood flow (CBF) is adjusted …