François Durand
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View article: Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis
Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis Open
The role of PN-1, a serpin that regulates both coagulation and fibrinolysis, is unknown in cirrhosis. PN-1 appears as an important regulator of fibrinolysis in patients with cirrhosis. The role of PN-1 (and platelets more broadly) should b…
View article: Role of Lymphopenia in Early prediction of Infection Following Orthotopic Liver Transplantation in Cirrhotic Patients
Role of Lymphopenia in Early prediction of Infection Following Orthotopic Liver Transplantation in Cirrhotic Patients Open
Infections remain a main cause of morbidity and mortality following orthotopic liver transplantation (OLT). Patients with end-stage liver cirrhosis exhibit a deregulation of their immune response, making them more susceptible to infections…
View article: Probability of a Condorcet Winner for Large Electorates: An Analytic Combinatorics Approach
Probability of a Condorcet Winner for Large Electorates: An Analytic Combinatorics Approach Open
We study the probability that a given candidate is an alpha-winner, i.e. a candidate preferred to each other candidate j by a fraction alpha_j of the voters. This extends the classical notion of Condorcet winner, which corresponds to the c…
View article: Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia
Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia Open
Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asi…
View article: Hepatopulmonary syndrome in patients with porto-sinusoidal vascular disorder: Characteristics and outcome
Hepatopulmonary syndrome in patients with porto-sinusoidal vascular disorder: Characteristics and outcome Open
Hepatopulmonary syndrome (HPS) is a rare complication of porto-sinusoidal vascular disorder (PSVD). This multicentric study found that patients with PSVD and HPS had less preserved liver function, and harbored genetic disorders more freque…
View article: Feasibility and acceptability of a systematic offer of HIV rapid testing to Family Planning Centers visitors by non-physician professionals in France
Feasibility and acceptability of a systematic offer of HIV rapid testing to Family Planning Centers visitors by non-physician professionals in France Open
Background The Human Immunodeficiency Virus (HIV) epidemic remains active among women in Europe, with significant missed opportunities for HIV testing. Although HIV testing falls within the scope of Family Planning Centers (FPCs), it is of…
View article: Emergent resistance-associated mutations at first- or second-line HIV-1 virologic failure with second-generation InSTIs in two- and three-drug regimens: the Virostar-1 study
Emergent resistance-associated mutations at first- or second-line HIV-1 virologic failure with second-generation InSTIs in two- and three-drug regimens: the Virostar-1 study Open
Background Second-generation integrase strand transfer inhibitors (InSTIs) have a high barrier to resistance and potent antiretroviral activity. They are recommended as first- or second-line (FL and SL) options in two- and three-drug regim…
View article: Anytime Sorting Algorithms (Extended Version)
Anytime Sorting Algorithms (Extended Version) Open
This paper addresses the anytime sorting problem, aiming to develop algorithms providing tentative estimates of the sorted list at each execution step. Comparisons are treated as steps, and the Spearman's footrule metric evaluates estimati…
View article: Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis
Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis Open
Objective Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, …
View article: Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting
Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting Open
Patients with cirrhosis are prone to developing acute kidney injury (AKI), a complication associated with a markedly increased in-hospital morbidity and mortality, along with a risk of progression to chronic kidney disease. Whereas patient…
View article: Predictive role of hepatic venous pressure gradient in bleeding events among patients with cirrhosis undergoing orthotopic liver transplantation
Predictive role of hepatic venous pressure gradient in bleeding events among patients with cirrhosis undergoing orthotopic liver transplantation Open
Major bleeding events during orthotopic liver transplantation (OLT) are associated with poor outcomes but the proportion of this risk related to portal hypertension is unclear. Our work shows that hepatic venous pressure gradient (HVPG), t…
View article: OP-4 DEVELOPMENT AND EXTERNAL VALIDATION OF A MODEL TO PREDICT MULTI-DRUG RESISTANT BACTERIAL INFECTIONS IN PATIENTS WITH CIRRHOSIS
OP-4 DEVELOPMENT AND EXTERNAL VALIDATION OF A MODEL TO PREDICT MULTI-DRUG RESISTANT BACTERIAL INFECTIONS IN PATIENTS WITH CIRRHOSIS Open
Empirical antibiotic treatment for suspected infections in cirrhosis is crucial. This study aimed to develop and validate a model to predict the probability of infections by multi-drug resistant organisms (MDRO) in patients with cirrhosis.…
View article: Use of genotypic HIV DNA testing: a DELPHI-type consensus
Use of genotypic HIV DNA testing: a DELPHI-type consensus Open
Objectives As many disparities in the clinical use of HIV DNA sequencing are observed, a DELPHI-type consensus was initiated in France to homogenize use, techniques and interpretation of results. Methods Based on a literature review and cl…
View article: Determinants of clinical response to empirical antibiotic treatment in patients with cirrhosis and bacterial and fungal infections—Results from the ICA “Global Study” (EABCIR-Global Study)
Determinants of clinical response to empirical antibiotic treatment in patients with cirrhosis and bacterial and fungal infections—Results from the ICA “Global Study” (EABCIR-Global Study) Open
Background: The administration of an appropriate empirical antibiotic treatment is essential in cirrhosis and severe bacterial infections. We aimed to investigate the predictors of clinical response of empirical antibiotic treatment in a p…
View article: The screening and management of sleep disturbances in people living with <scp>HIV</scp>: Delphi consensus
The screening and management of sleep disturbances in people living with <span>HIV</span>: Delphi consensus Open
Summary Sleep disturbances in people living with HIV (PLHIV) are frequent but their management remains insufficient. In the absence of specific recommendations, a DELPHI consensus research project was conducted in France to establish best …
View article: Two Liver Transplant Center’s Experience of Dengue-Associated Acute Liver Injury
Two Liver Transplant Center’s Experience of Dengue-Associated Acute Liver Injury Open
Background: Acute liver failure is an uncommon, but often fatal, complication of dengue virus infection in adults.Aims: In this study, we aimed to evaluate the occurrence of a major adverse event to propose a management strategy.Methods: T…
View article: Sorting wild pigs
Sorting wild pigs Open
Chjara, breeder in Carg{è}se, has n wild pigs. She would like to sort her herd by weight to better meet the demands of her buyers. Each beast has a distinct weight, alas unknown to Chjara. All she has at her disposal is a Roberval scale, w…
View article: Fragility index of positive phase II and III randomised clinical trials of treatments for hepatocellular carcinoma (2002–2022)
Fragility index of positive phase II and III randomised clinical trials of treatments for hepatocellular carcinoma (2002–2022) Open
The fragility index is a method to assess robustness of a clinical trial and is defined the minimum number of best survivors reassigned to the control group required to revert the statistically significant result of a clinical trial to non…
View article: Postural adjustments preceding string release in trained archers
Postural adjustments preceding string release in trained archers Open
Optimal postural stability is required to perform in archery. Since the dynamic consequences of the string release may disturb postural equilibrium, they should be integrated into an archer motor programme to optimize postural stability. T…
View article: Data from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis
Data from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis Open
Purpose: Cirrhosis is a major risk factor for the development of hepatocellular carcinoma but remains underdiagnosed in the compensated stage. Fibrosis progression and cirrhosis are associated with changes in blood serum glycomic profiles.…
View article: GlycoCirrhoTest and related glycomics-based biomarkers for liver disease from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis
GlycoCirrhoTest and related glycomics-based biomarkers for liver disease from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis Open
This file gives additional information regarding the GlycoCirrhoTest and other glycomics-based test based on the same technology (DSA-FACE) for glycomic analysis.
View article: Data from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis
Data from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis Open
Purpose: Cirrhosis is a major risk factor for the development of hepatocellular carcinoma but remains underdiagnosed in the compensated stage. Fibrosis progression and cirrhosis are associated with changes in blood serum glycomic profiles.…
View article: GlycoCirrhoTest and related glycomics-based biomarkers for liver disease from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis
GlycoCirrhoTest and related glycomics-based biomarkers for liver disease from A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis Open
This file gives additional information regarding the GlycoCirrhoTest and other glycomics-based test based on the same technology (DSA-FACE) for glycomic analysis.