Sherif F. El‐Khamisy
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View article: Second generation lethality in RNAseH2a knockout zebrafish
Second generation lethality in RNAseH2a knockout zebrafish Open
Removal of ribonucleotides from DNA by RNaseH2 is essential for genome stability, and its impacted function causes the neurodegenerative disease, Aicardi Goutières Syndrome. We have created a zebrafish rnaseh2a mutant to model this process…
View article: Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells
Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells Open
Targeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical…
View article: The DNA repair kinase ATM regulates CD13 expression and cell migration
The DNA repair kinase ATM regulates CD13 expression and cell migration Open
Classically, ATM is known for its role in sensing double-strand DNA breaks, and subsequently signaling for their repair. Non-canonical roles of ATM include transcriptional silencing, ferroptosis, autophagy and angiogenesis. Angiogenesis me…
View article: A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis
A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis Open
The treatment of HCV and its sequelae are used to be predominantly based on Interferon (IFN). However, this was associated with significant adverse events as a result of its immunostimulant capabilities. Since their introduction, the direc…
View article: Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma
Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma Open
Introduction Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a site defined subtype of head and neck cancer with two distinct clinical subtypes: HPV-associated (HPV+) and HPV-independent (HPV-); both of which are commonly treated with che…
View article: Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools Open
Cells are constantly exposed to various sources of DNA damage that pose a threat to their genomic integrity. One of the most common types of DNA breaks are single-strand breaks (SSBs). Mutations in the repair proteins that are important fo…
View article: Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges
Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges Open
Skeletal muscles undergo macroscopic changes, including atrophy and myosteatosis, alongside microscopic changes in their phenotype due to aging. Sarcopenia is a muscle disease that affects older people and is characterized by the progressi…
View article: High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes
High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes Open
The DNA Damage Response (DDR) pathways sense DNA damage and coordinate robust DNA repair and bypass mechanisms. A series of repair proteins are recruited depending on the type of breaks and lesions to ensure overall survival. An increase i…
View article: Genome-wide association study for systemic lupus erythematosus in an egyptian population
Genome-wide association study for systemic lupus erythematosus in an egyptian population Open
Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European an…
View article: Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence
Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence Open
Technological advancements in the present era have enhanced drug discovery and development. Nanomedicines are valuable pharmacotherapeutic tools against several diseases and disorders including aging related disorders. The mechanistic asso…
View article: Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges
Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges Open
Skeletal muscles undergo macroscopic changes, including atrophy and myosteatosis, alongside microscopic changes in their phenotype due to ageing. Sarcopenia is a muscle disease that affects older people and is characterised by the progress…
View article: CORM-3 induces DNA damage through Ru(II) binding to DNA
CORM-3 induces DNA damage through Ru(II) binding to DNA Open
When the ‘CO-releasing molecule-3’, CORM-3 (Ru(CO)3Cl(glycinate)), is dissolved in water it forms a range of ruthenium complexes. These are taken up by cells and bind to intracellular ligands, notably thiols such as cysteine and glutathion…
View article: Editorial: Genomic Instability and Neurodegeneration
Editorial: Genomic Instability and Neurodegeneration Open
International audience
View article: SMN-deficient cells exhibit increased ribosomal DNA damage
SMN-deficient cells exhibit increased ribosomal DNA damage Open
Spinal muscular atrophy, the leading genetic cause of infant mortality, is a motor neuron disease caused by low levels of survival motor neuron (SMN) protein. SMN is a multifunctional protein that is implicated in numerous cytoplasmic and …
View article: Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661–PTPN11 mRNA Axis
Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661–PTPN11 mRNA Axis Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in Egypt. A deep understanding of the molecular events occurring in HCC can facilitate the development of novel diagnostic and/or therapeutic approaches. In the pres…
View article: A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance Open
Ribonucleoside monophosphate (rNMP) incorporation in genomic DNA poses a significant threat to genomic integrity. In addition to repair, DNA damage tolerance mechanisms ensure replication progression upon encountering unrepaired lesions. O…
View article: DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat
DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat Open
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affec…
View article: High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice
High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice Open
Cancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing …
View article: Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma
Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma Open
Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain tumours being diagnosed as high-grade malignancies known as glioblastomas. Despite de-bulking surgery combined with chemo-…
View article: Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development
Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development Open
The repair of protein-linked chromosomal breaks requires distinct factors throughout the life span.