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View article: Cogni-e-SpinDB 1.0: Open Dataset of Electrospinning Parameter Configurations and Resultant Nanofiber Morphologies
Cogni-e-SpinDB 1.0: Open Dataset of Electrospinning Parameter Configurations and Resultant Nanofiber Morphologies Open
Electrospinning is a versatile technique for producing nanofibers by elongating and depositing a polymer solution in an electrostatic field. Nanofiber quality is governed by process, environmental, and solution parameters, requiring extens…
View article: Thermal Characterization Methods of Novel Substrate Materials Utilized in IGBT Modules
Thermal Characterization Methods of Novel Substrate Materials Utilized in IGBT Modules Open
In this article, thermal investigation methods for electrically insulating and thermally conductive substrate materials will be presented. The investigations were performed in their real-world application environment, i.e., in the form of …
View article: Detailed Studies on the Methoxylation and Subsequent Dealkylation of N,N-Diethylbenzenesulfonamide Using a Tailor-Made Electrosynthetic Reactor
Detailed Studies on the Methoxylation and Subsequent Dealkylation of N,N-Diethylbenzenesulfonamide Using a Tailor-Made Electrosynthetic Reactor Open
Benzenesulfonamides are an outstandingly important family of compounds in organic and medicinal chemistry. Herein, we report detailed studies on the electrochemical mono- and dideethylation of model compound N,N-diethylbenzenesulfonamide. …
View article: Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique
Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique Open
The application of enzyme-based therapies has received significant attention in modern drug development. Lipases are one of the most versatile enzymes that can be used as therapeutic agents in basic skin care and medical treatment related …
View article: Novel Approach for the Isolation and Immobilization of a Recombinant Transaminase: Applying an Advanced Nanocomposite System
Novel Approach for the Isolation and Immobilization of a Recombinant Transaminase: Applying an Advanced Nanocomposite System Open
The increasing application of recombinant enzymes demands not only effective and sustainable fermentation, but also highly efficient downstream processing and further stabilization of the enzymes by immobilization. In this study, a novel a…
View article: Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin
Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin Open
The investigation of liver-related metabolic stability of a drug candidate is a widely used key strategy in early-stage drug discovery. Metalloporphyrin-based biomimetic catalysts are good and well-described models of the function of CyP45…
View article: Novel biomimetic nanocomposite for investigation of drug metabolism
Novel biomimetic nanocomposite for investigation of drug metabolism Open
In vitro mimicking of hepatic drug metabolism is a key issue in early-stage drug discovery. Synthetic metalloporphyrins show structural similarity with the heme type prosthetic group of cytochrome P450 as primary hepatic enzyme in oxidativ…
View article: Entrapment of Phenylalanine Ammonia-Lyase in Nanofibrous Polylactic Acid Matrices by Emulsion Electrospinning
Entrapment of Phenylalanine Ammonia-Lyase in Nanofibrous Polylactic Acid Matrices by Emulsion Electrospinning Open
Immobilization of the recombinant, plant-derived Petroselinum crispum phenylalanine ammonia lyase (PcPAL) in electrospun matrices have the potential to create promising, easy-to-use biocatalysts. Polylactic acid (PLA) a biologically inert,…
View article: Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors Open
The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) po…
View article: Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor Open
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) p…
View article: A Novel Method for Fabricating Microfluidic Devices Containing Immobilized Biological Specimens
A Novel Method for Fabricating Microfluidic Devices Containing Immobilized Biological Specimens Open
Microfluidic devices are dominantly fabricated using the soft lithography microfabrication techniques and polydimethylsiloxane (PDMS) as a structural material. Although the technique is applicable for the majority of microfluidic devices, …
View article: Preparation and Characterization of Biocompatible Electrospun Nanofiber Scaffolds
Preparation and Characterization of Biocompatible Electrospun Nanofiber Scaffolds Open
Nanoscale fibers were prepared for the fabrication of scaffolds by using a strong electrostatic field on the polymer solution. Electrospinning is widely applied for production of drug delivery, tissue engineering, and regenerative medicine…
View article: Electrospun Nanofibers for Entrapment of Biomolecules
Electrospun Nanofibers for Entrapment of Biomolecules Open
This chapter focuses on nanofiber fabrication by electrospinning techniques for the effective immobilization of biomolecules (such as enzymes or active pharmaceutical ingredients—APIs). In this chapter, the development of precursor materia…
View article: Geometric optimization of microreactor chambers to increase the homogeneity of the velocity field
Geometric optimization of microreactor chambers to increase the homogeneity of the velocity field Open
In this work microfluidic flow-through chambers are investigated. They are filled with magnetic nanoparticle (MNP) suspension in order to facilitate enzymatic reactions. The enzyme is immobilized on the surface of the MNPs. These reactions…
View article: Microfluidic Multiple Chamber Chip Reactor Filled with Enzyme-Coated Magnetic Nanoparticles
Microfluidic Multiple Chamber Chip Reactor Filled with Enzyme-Coated Magnetic Nanoparticles Open
In this chapter, a novel microfluidic device (MagneChip) is described which comprises microliter volume reaction chambers filled with magnetically fixed enzyme-coated magnetic nanoparticles (ecMNPs) and with an in-line UV detector. In the …