Foo Y. Liew
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View article: Cigarette smoke induces <i>miR-132</i> in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Cigarette smoke induces <i>miR-132</i> in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis Open
Significance This report reveals a mechanism by which cigarette smoke (CS) could exacerbate local inflammatory disease. CS is a key environmental pollutant affecting millions of people globally and continues to be of considerable interest …
View article: Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response
Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response Open
Targeting STAT pathways may offer previously unidentified approaches in the management of fibrotic disorders.
View article: Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis Open
View article: CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis
CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis Open
Neutrophils and inflammatory monocytes control sepsis by migration to the site of infection via their chemokine receptors. CCR5 is a chemokine receptor that is not expressed on neutrophils and inflammatory monocytes under homeostatic condi…
View article: Interleukin‐33 contributes to disease severity in <i>Dengue virus</i> infection in mice
Interleukin‐33 contributes to disease severity in <i>Dengue virus</i> infection in mice Open
Summary The excessive inflammation often present in patients with severe dengue infection is considered both a hallmark of disease and a target for potential treatments. Interleukin‐33 (IL‐33) is a pleiotropic cytokine with pro‐inflammator…
View article: Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria Open
Significance Cerebral malaria (CM) is a neurological complication of malaria infection that, despite antimalarial drug treatment, results in fatality or neurodisability in approximately 25% of cases. Thus, there is an urgent clinical need …
View article: Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells
Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells Open
View article: Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis
Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis Open
The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigate…
View article: TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis Open
View article: The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis
The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis Open
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection, and chemokines play a key role in recruiting neutrophils. However, in sepsis chemok…
View article: IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Open
View article: IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline Open
Significance Dysfunction of the innate immune system is involved in the pathogenesis of Alzheimer’s disease (AD); however, the pathophysiological mechanisms underlying these dysfunctions are unclear. Here we report that stimulation of IL-3…
View article: Spinal cord oligodendrocyte‐derived alarmin IL‐33 mediates neuropathic pain
Spinal cord oligodendrocyte‐derived alarmin IL‐33 mediates neuropathic pain Open
Neuropathic pain from injury to the peripheral and CNS represents a major health care issue. We have investigated the role of IL‐33/IL‐33 receptor (ST2) signaling in experimental models of neuropathic pain in mice. Chronic constriction inj…
View article: MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease Open
View article: Cigarette Smoke Resets the Alarmin IL-33 in COPD
Cigarette Smoke Resets the Alarmin IL-33 in COPD Open
View article: Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis Open
Significance Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis (RA). However, about 40% of patients are resistant to MTX. Furthermore, MTX resistance is only apparent after a prolonged continuous MTX treatment (>3 mo), …