F. Hafna Ahmed
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View article: Thermostable Bacterial Esterases From Lipase Family 1.5 Degrade Compostable Polyesters PBAT and PBSA
Thermostable Bacterial Esterases From Lipase Family 1.5 Degrade Compostable Polyesters PBAT and PBSA Open
The escalating plastics crisis, exacerbated by the accumulation of nonbiodegradable polyesters in the environment, has necessitated the exploration of sustainable waste management solutions such as enzymatic hydrolysis in industrial recycl…
View article: Harnessing the biomolecular mechanisms of marine biomineralisation for carbon sequestration
Harnessing the biomolecular mechanisms of marine biomineralisation for carbon sequestration Open
View article: A F420-dependent Single Domain Chemogenetic Tool for Protein De-dimerization
A F420-dependent Single Domain Chemogenetic Tool for Protein De-dimerization Open
Protein-protein interactions (PPIs) mediate many fundamental cellular processes. Control of PPIs through optically or chemically responsive protein domains has had a profound impact on basic research and some clinical applications. Most ch…
View article: Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA)
Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA) Open
View article: The complex inhibitory mechanism of glycomimetics with human heparanase
The complex inhibitory mechanism of glycomimetics with human heparanase Open
Heparanase (HPSE) is the only mammalian endo-β-glucuronidase known to catalyse the degradation of heparan sulfate. Dysfunction of HPSE activity has been linked to several disease states, resulting in HPSE becoming the target of numerous th…
View article: A F<sub>420</sub>-dependent single domain chemogenetic tool for protein de-dimerization
A F<sub>420</sub>-dependent single domain chemogenetic tool for protein de-dimerization Open
Protein-protein interactions (PPIs) mediate many fundamental cellular processes and their control through optically or chemically responsive protein domains has a profound impact on basic research and some clinical applications. Most avail…
View article: Quantification of T Cell Subsets in Bangladeshi COVID-19 Patients Creating Prospects towards Broader Research and Improved Patient Care
Quantification of T Cell Subsets in Bangladeshi COVID-19 Patients Creating Prospects towards Broader Research and Improved Patient Care Open
not available J Bangladesh Coll Phys Surg 2022; 40: 213-215
View article: In search of novel inhibitors of anti-cancer drug target fibroblast growth factor receptors: Insights from virtual screening, molecular docking, and molecular dynamics
In search of novel inhibitors of anti-cancer drug target fibroblast growth factor receptors: Insights from virtual screening, molecular docking, and molecular dynamics Open
Fibroblast growth factor receptors (FGFR) are an essential player in oncogenesis and tumor progression. LY2874455 was identified as a pan-FGFR inhibitor and has gone through phase I clinical trial. In the current study, virtual screening w…
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering Open
View article: The evolution of nitroimidazole antibiotic resistance in <i>Mycobacterium tuberculosis</i>
The evolution of nitroimidazole antibiotic resistance in <i>Mycobacterium tuberculosis</i> Open
Our inability to predict whether certain mutations will confer antibiotic resistance has made it difficult to rapidly detect the emergence of resistance, identify pre-existing resistant populations and manage our use of antibiotics to effe…
View article: FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress
FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress Open
View article: The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria
The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria Open
F420 is a low-potential redox cofactor that mediates the transformations of a wide range of complex organic compounds. Considered one of the rarest cofactors in biology, F420 is best known for its role in methanogenesis and has only been c…
View article: Rv2074 is a novel F<sub>420</sub>H<sub>2</sub>‐dependent biliverdin reductase in<i>Mycobacterium tuberculosis</i>
Rv2074 is a novel F<sub>420</sub>H<sub>2</sub>‐dependent biliverdin reductase in<i>Mycobacterium tuberculosis</i> Open
Bilirubin is a potent antioxidant that is produced from the reduction of the heme degradation product biliverdin. In mammalian cells and Cyanobacteria, NADH/NADPH‐dependent biliverdin reductases (BVRs) of the Rossmann‐fold have been shown …
View article: Physiology, Biochemistry, and Applications of F<sub>420</sub>- and F<sub>o</sub>-Dependent Redox Reactions
Physiology, Biochemistry, and Applications of F<sub>420</sub>- and F<sub>o</sub>-Dependent Redox Reactions Open
SUMMARY 5-Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin, 5-deazaflavins have distinctive and biologic…
View article: Protonation state of F<sub>420</sub>H<sub>2</sub>in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis
Protonation state of F<sub>420</sub>H<sub>2</sub>in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis Open
Theoretical and experimental studies of the deazaflavin dependent nitroreductase (Ddn) enzyme bound cofactor F420demonstrate that the reduced cofactor is deprotonated in the holoenzyme form.