Ming‐Feng Hou
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View article: Remnant cholesterol to high density lipoprotein cholesterol ratio is correlated with bone mineral density: Analysis of NHANES 2011–2018
Remnant cholesterol to high density lipoprotein cholesterol ratio is correlated with bone mineral density: Analysis of NHANES 2011–2018 Open
Emerging evidence suggests that lipid metabolism plays a critical role in bone homeostasis. The ratio of remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) has recently been proposed as a novel indicator of metabolic risk;…
View article: Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-Phase chronic myeloid leukemia (CML-CP) in a registrational randomized Phase 2 trial: Up to 4-year follow-up including patients without T315I mutations
Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-Phase chronic myeloid leukemia (CML-CP) in a registrational randomized Phase 2 trial: Up to 4-year follow-up including patients without T315I mutations Open
Introduction This was a multicenter, randomized, registrational phase 2 study to assess efficacy and safety of olverembatinib vs. BAT in pts with CML-CP resistant and/or intolerant to three TKIs (imatinib [I]), dasatinib [D], nilotinib [N]…
View article: Immunotherapy without or with low-intensity chemotherapy versus standard chemotherapy as first-line treatment for newly diagnosed b-ALL patients: A propensity score-matched study
Immunotherapy without or with low-intensity chemotherapy versus standard chemotherapy as first-line treatment for newly diagnosed b-ALL patients: A propensity score-matched study Open
Introduction： B-cell acute lymphoblastic leukemia(B-ALL) is a common malignant tumour of the blood system.With a high frequency of severe side effects and low tolerance to standard chemotherapy, some patients have a poor prognosis.Therefor…
View article: 188 Self-oxygenating PROTAC microneedles for spatiotemporally-tunable protein degradation and enhanced small cell lung cancer therapy
188 Self-oxygenating PROTAC microneedles for spatiotemporally-tunable protein degradation and enhanced small cell lung cancer therapy Open
View article: Genome-wide association, single-cell, and spatial transcriptomics analyses reveal the role of the STK24-expressing positive cells in LUAD progression and the tumor microenvironment, identifying STK24 as a potential therapeutic target
Genome-wide association, single-cell, and spatial transcriptomics analyses reveal the role of the STK24-expressing positive cells in LUAD progression and the tumor microenvironment, identifying STK24 as a potential therapeutic target Open
STK24, an apoptosis-related gene, promotes LUAD progression by enhancing proliferation and inhibiting apoptosis, with STK24posEpi interacting in the tumor microenvironment through PDGF and MIF pathways. These findings offer potential thera…
View article: Elevated METS-IR is associated with an increased risk of osteoarthritis: A cross-sectional NHANES-based study
Elevated METS-IR is associated with an increased risk of osteoarthritis: A cross-sectional NHANES-based study Open
Osteoarthritis (OA) is a prevalent chronic joint disease, metabolic abnormalities may play a key role in its development and progression. The metabolic score for insulin resistance (METS-IR) is an emerging index used to assess insulin resi…
View article: Red-eared slider turtle <i>–Mycobacterium marinum</i> infection model
Red-eared slider turtle <i>–Mycobacterium marinum</i> infection model Open
Mycobacterium marinum serves as an ideal model organism for studying tuberculosis due to its genetic similarity to Mycobacterium tuberculosis . However, there is a need for more suitable animal models to study M. marinum infections. In thi…
View article: Integrated Multi-Omics Reveals Caries Mechanisms In Preschoolers
Integrated Multi-Omics Reveals Caries Mechanisms In Preschoolers Open
Aim or purpose: Preschool caries, linked to oral microbiome dysbiosis, lacks age-specific prevention. By applying integrated multi-omics, we unravel age-specific ecological-metabolic networks driving caries pathogenesis, revealing microbe-…
View article: YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis
YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis Open
Background Through evolutionary genomics analysis, we identified Yulink (MIOS, Entrez Gene: 54,468), a highly conserved gene encoding an 875 amino acid protein with diverse functions in humans. Given the importance of accelerated glycolysi…
View article: The relationship between prognostic nutritional index and its components (albumin and lymphocyte count) and all-cause mortality in lung cancer patients: a hospital-based study with database external validation
The relationship between prognostic nutritional index and its components (albumin and lymphocyte count) and all-cause mortality in lung cancer patients: a hospital-based study with database external validation Open
Objective This study aimed to evaluate the prognostic value of the Prognostic Nutritional Index (PNI), derived from serum albumin and lymphocyte count, in predicting all-cause mortality among lung cancer patients, using both a hospital-bas…
View article: Neoadjuvant palbociclib in women with operable, hormone receptor-positive breast cancer
Neoadjuvant palbociclib in women with operable, hormone receptor-positive breast cancer Open
The addition of a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor to endocrine therapy augments biological response in breast cancer. This phase III randomized, double-blind study evaluated the efficacy of adding palbociclib to neoadjuvant …
View article: Sepsis-driven metabolic reprogramming shapes cancer immunotherapy efficacy, metastatic potential, and drug sensitivity
Sepsis-driven metabolic reprogramming shapes cancer immunotherapy efficacy, metastatic potential, and drug sensitivity Open
Sepsis and cancer interact in a complex, bidirectional manner that significantly impacts patient prognosis, with metabolic reprogramming being a key factor. Sepsis-induced immune dysregulation and metabolic changes promote immunosuppressio…
View article: Transosseous suture in situ repair treatment of a femoral anterior cruciate ligament avulsion fracture in a 30-year-old male patient: a case report and review of the literature
Transosseous suture in situ repair treatment of a femoral anterior cruciate ligament avulsion fracture in a 30-year-old male patient: a case report and review of the literature Open
Background Avulsion fractures typically occur at the tibial insertion site of the anterior cruciate ligament (ACL), while femoral ACL injuries usually involve midsubstance tears rather than bony avulsions. In previous case reports, femoral…
View article: P.150 Spontaneous regression of vestibular schwannoma: a clinical and radiographic characterization
P.150 Spontaneous regression of vestibular schwannoma: a clinical and radiographic characterization Open
Background: Vestibular schwannoma (VS) are the most common tumour of the CPA with an annual incidence of 17.4/1 million. They typically demonstrate slow growth over time and as such, observation is a reasonable approach to management. A po…
View article: Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights
Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights Open
View article: The Impact of Intelligence on Digital Transformation of Enterprises
The Impact of Intelligence on Digital Transformation of Enterprises Open
Chinese enterprises have entered a new stage of digital development and are accelerating towards the stage of comprehensive intelligent development. With the deepening of a new round of technological revolution, intelligent technologies su…
View article: Dynamic change in Epstein-Barr virus DNA predicts prognosis in early stage natural killer/T-cell lymphoma with pegaspargase-based treatment: long-term follow-up and biomarker analysis from the NHL-004 multicenter randomized study
Dynamic change in Epstein-Barr virus DNA predicts prognosis in early stage natural killer/T-cell lymphoma with pegaspargase-based treatment: long-term follow-up and biomarker analysis from the NHL-004 multicenter randomized study Open
The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, etoposide, dexamethasone and pegaspargase (MESA) regimen, combined with sandwiched radiotherapy, in newly diagn…
View article: Prediction of Metastasis in Small Pulmonary Oligonodules Detected in Breast Cancer Patients at Baseline <scp>CT</scp>
Prediction of Metastasis in Small Pulmonary Oligonodules Detected in Breast Cancer Patients at Baseline <span>CT</span> Open
It is challenging for radiologists to diagnose pulmonary metastases when they encounter only a few ( n ≤ 5) small pulmonary nodules (< 10 mm) on staging CT in breast cancer patients. We conducted this study to assess clinical and imaging f…
View article: NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling
NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling Open
Breast cancer is the most prevalent cancer among women. Previous studies demonstrated that adipose-derived stem cells (ADSCs) co-cultured with resistin promote malignant behaviors in breast cancer cells. This study explores the roles of AD…
View article: A new pathogen pattern of acute respiratory tract infections in primary care after COVID-19 pandemic: a multi-center study in southern China
A new pathogen pattern of acute respiratory tract infections in primary care after COVID-19 pandemic: a multi-center study in southern China Open
After the COVID-19 pandemic, the main viral pathogens of ARTIs were unevenly distributed, and less bacterial and atypical pathogens were detected in primary care. The microbiological evidences can optimize the precision diagnosis and treat…
View article: Long-Term Outcomes of Adjuvant Radiation in Elderly Asians with Early Stage Iia Breast Cancer after Breast-Conserving Surgery
Long-Term Outcomes of Adjuvant Radiation in Elderly Asians with Early Stage Iia Breast Cancer after Breast-Conserving Surgery Open
View article: Measurable Residual Disease Before the Second Consolidation Guides Monitoring in Acute Promyelocytic Leukemia Treated with Retinoic Acid and Arsenic Trioxide
Measurable Residual Disease Before the Second Consolidation Guides Monitoring in Acute Promyelocytic Leukemia Treated with Retinoic Acid and Arsenic Trioxide Open
View article: Short-Range Nonstationary Clutter Suppression for Airborne KA-STAP Radar in Complex Terrain Environment
Short-Range Nonstationary Clutter Suppression for Airborne KA-STAP Radar in Complex Terrain Environment Open
Due to the range ambiguity effect and the complex terrain environment, the remote weak target of interest for nonsidelooking airborne radar is usually superimposed with the nonstationary and heterogeneous short-range strong clutter, so it …
View article: DCAFusion: A novel general image fusion framework based on reference image reconstruction and dual-cross attention mechanism
DCAFusion: A novel general image fusion framework based on reference image reconstruction and dual-cross attention mechanism Open
View article: Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics
Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics Open
The Triple-Negative Breast Cancer (TNBC) subtype constitutes 15-20% of breast cancer cases and is associated with the poorest clinical outcomes. Distant metastasis, particularly to the lungs, is a major contributor to the high mortality ra…
View article: Real-world outcomes of everolimus-based treatment in a Taiwanese cohort with metastatic HR+/HER2− breast cancer
Real-world outcomes of everolimus-based treatment in a Taiwanese cohort with metastatic HR+/HER2− breast cancer Open
Background: Everolimus was the first orally targeted therapy for certain cancers. It was introduced before CDK4/6 inhibitors and is widely used to treat advanced hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-nega…
View article: Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer
Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer Open
Targeting Bmi1 may offer a promising adjunctive therapeutic strategy when administering traditional chemotherapy regimens to patients with advanced CRC.
View article: Efficacy of the minimal-invasive vacuum-assisted biopsy under direct visualization with ultrasound for impalpable breast lesions in Taiwanese female: A retrospective case-control study
Efficacy of the minimal-invasive vacuum-assisted biopsy under direct visualization with ultrasound for impalpable breast lesions in Taiwanese female: A retrospective case-control study Open
Background Although surgical excisional biopsy provides robust diagnostic results, the ultrasound-assisted vacuum-assisted biopsy (VABB) offers an alternative for Asian candidates with dense breasts and lesions which cannot be approached b…
View article: Predicting the association of different levels of physical activity on postoperative pulmonary complications using the international physical activity questionnaire in patients undergoing thoracoscopic lung surgery under general anaesthesia: protocol for a prospective cohort study
Predicting the association of different levels of physical activity on postoperative pulmonary complications using the international physical activity questionnaire in patients undergoing thoracoscopic lung surgery under general anaesthesia: protocol for a prospective cohort study Open
Introduction Postoperative pulmonary complications (PPCs) occur frequently in patients undergoing lung surgery under general anaesthesia and are strongly associated with longer postoperative hospital stays and increased mortality. The exis…
View article: A novel biodegradable magnesium skin staple: A safety and functional evaluation
A novel biodegradable magnesium skin staple: A safety and functional evaluation Open
Our results confirm the safety, biocompatibility, and functionality of the novel Mg skin staple in wound closure. The efficacy of the staple in wound closure was demonstrated to be as effectively as conventional staples, with the added ben…