Fabian Kloosterman
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View article: Specific anterior-posterior brain-wide input patterns support specialized visuospatial processing in the mouse retrosplenial cortex
Specific anterior-posterior brain-wide input patterns support specialized visuospatial processing in the mouse retrosplenial cortex Open
The retrosplenial cortex (RSC) is a key integrative hub involved in spatial orientation, navigation, and diverse cognitive and mnemonic processes. In rodents, RSC neurons carry rich sensory and navigational signals and are interconnected w…
View article: Protocol for closed-loop optogenetic manipulation of cortical activity following hippocampal sharp-wave ripples in freely behaving rats
Protocol for closed-loop optogenetic manipulation of cortical activity following hippocampal sharp-wave ripples in freely behaving rats Open
Temporally and spatially selective closed-loop perturbation of brain activity can be used to reveal the contribution of spontaneous neural events to behavior. Here, we present a protocol for optogenetic inhibition of the medial prefrontal …
View article: Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples
Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples Open
The hippocampus is known to encode spatial information and reactivate experienced trajectories during sharp-wave ripple events. These events are thought to be key time-points at which information about learned trajectories is transferred t…
View article: Neurons in the medial prefrontal cortex that are not modulated by hippocampal sharp-wave ripples are involved in spatial tuning and signaling upcoming choice
Neurons in the medial prefrontal cortex that are not modulated by hippocampal sharp-wave ripples are involved in spatial tuning and signaling upcoming choice Open
The hippocampus is known to encode spatial information and reactivate experienced trajectories during sharp-wave ripple events. These events are thought to be key time-points at which information about learned trajectories is transferred t…
View article: NeuroCarto: A Toolkit for Building Custom Read-out Channel Maps for High Electrode-count Neural Probes
NeuroCarto: A Toolkit for Building Custom Read-out Channel Maps for High Electrode-count Neural Probes Open
Neuropixels probes contain thousands of electrodes across one or more shanks and are sufficiently small to allow chronic recording of neural activity in freely behaving small animals. However, the joint increase in the number of electrodes…
View article: Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples
Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples Open
The hippocampus is known to encode spatial information and reactivate experienced trajectories during sharp-wave ripple events. These events are thought to be key time-points at which information about learned trajectories is transferred t…
View article: Theta cycle dynamics of spatial representations in the lateral septum
Theta cycle dynamics of spatial representations in the lateral septum Open
Summary An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a…
View article: Reviewer #1 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum
Reviewer #1 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum Open
An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a spatial…
View article: Author response: Theta cycle dynamics of spatial representations in the lateral septum
Author response: Theta cycle dynamics of spatial representations in the lateral septum Open
An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a spatial…
View article: Reviewer #2 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum
Reviewer #2 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum Open
An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a spatial…
View article: Disruption of awake sharp-wave ripples does not affect memorization of locations in repeated-acquisition spatial memory tasks
Disruption of awake sharp-wave ripples does not affect memorization of locations in repeated-acquisition spatial memory tasks Open
Storing and accessing memories is required to successfully perform day-to-day tasks, for example for engaging in a meaningful conversation. Previous studies in both rodents and primates have correlated hippocampal cellular activity with be…
View article: Reviewer #2 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum
Reviewer #2 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum Open
An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a spatial…
View article: Theta cycle dynamics of spatial representations in the lateral septum
Theta cycle dynamics of spatial representations in the lateral septum Open
Summary An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a…
View article: Theta cycle dynamics of spatial representations in the lateral septum
Theta cycle dynamics of spatial representations in the lateral septum Open
Summary An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a…
View article: Reviewer #1 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum
Reviewer #1 (Public Review): Theta cycle dynamics of spatial representations in the lateral septum Open
An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a spatial…
View article: Sharp-wave-ripple-associated activity in the medial prefrontal cortex supports spatial rule switching
Sharp-wave-ripple-associated activity in the medial prefrontal cortex supports spatial rule switching Open
Previous studies have highlighted an important role for hippocampal sharp-wave ripples in spatial alternation learning, as well as in modulating activity in the medial prefrontal cortex (mPFC). However, the direct influence of hippocampal …
View article: Theta cycle dynamics of spatial representations in the lateral septum
Theta cycle dynamics of spatial representations in the lateral septum Open
Summary An internal representation of the environment – or map – allows animals to evaluate multiple routes and adapt their navigation strategy to current needs and future goals. The hippocampal formation plays a crucial role in learning a…
View article: Awake hippocampal replay is not required for short-term memory
Awake hippocampal replay is not required for short-term memory Open
Short-term memory (STM) on a time scale of seconds to minutes is required to successfully perform day-to-day tasks, for example when engaging in a meaningful conversation. Previous studies in both rodents and primates have correlated hippo…
View article: Sharp-wave ripple associated activity in the medial prefrontal cortex supports spatial rule switching
Sharp-wave ripple associated activity in the medial prefrontal cortex supports spatial rule switching Open
Previous studies have highlighted an important role for hippocampal sharp-wave ripples in spatial alternation learning, as well as modulating activity in the medial prefrontal cortex (mPFC). However, no study so far has investigated the di…
View article: Simultaneous Cellular Imaging, Electrical Recording and Stimulation of Hippocampal Activity in Freely Behaving Mice
Simultaneous Cellular Imaging, Electrical Recording and Stimulation of Hippocampal Activity in Freely Behaving Mice Open
Hippocampal sharp-wave ripple activity (SWRs) and the associated replay of neural activity patterns are well-known for their role in memory consolidation. This activity has been studied using electrophysiological approaches, as high tempor…
View article: Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings Open
Recording many neurons for a long time The ultimate aim of chronic recordings is to sample from the same neuron over days and weeks. However, this goal has been difficult to achieve for large populations of neurons. Steinmetz et al. descri…
View article: Single-trial dynamics of hippocampal spatial representations are modulated by reward value
Single-trial dynamics of hippocampal spatial representations are modulated by reward value Open
Reward value is known to modulate learning speed in spatial memory tasks, but little is known about its influence on the dynamical changes in hippocampal spatial representations. Here, we monitored the trial-to-trial changes in hippocampal…
View article: A Dual Reward-Place Association Task to Study the Preferential Retention of Relevant Memories in Rats
A Dual Reward-Place Association Task to Study the Preferential Retention of Relevant Memories in Rats Open
Memories of past events and common knowledge are critical to flexibly adjust one's future behavior based on prior experiences. The formation and the transformation of these memories into a long-lasting form are supported by a dialogue betw…
View article: A Dual Reward-Place Association Task to Study the Preferential Retention of Relevant Memories in Rats
A Dual Reward-Place Association Task to Study the Preferential Retention of Relevant Memories in Rats Open
Memories of past events and common knowledge are critical to flexibly adjust one’s future behavior based on prior experiences. The formation and the transformation of these memories into a long-lasting form are supported by a dialog betwee…