Fuminori Kobayashi
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View article: Principal Curves In Metric Spaces And The Space Of Probability Measures
Principal Curves In Metric Spaces And The Space Of Probability Measures Open
We introduce principal curves in Wasserstein space, and in general compact metric spaces. Our motivation for the Wasserstein case comes from optimal-transport-based trajectory inference, where a developing population of cells traces out a …
View article: Identification of three QTLs that additively affect heading time in bread wheat (Triticum aestivum L.) by QTL-seq approach
Identification of three QTLs that additively affect heading time in bread wheat (Triticum aestivum L.) by QTL-seq approach Open
Optimizing the timing of heading is crucial for achieving stable production in bread wheat ( Triticum aestivum L.). We analyzed a breeding line, ‘B1-0393’, that headed 5 days earlier than the Japanese elite cultivar ‘Kitahonami’. To identi…
View article: Identification of three QTLs that additively affect heading time in bread wheat (Triticum aestivum L.) by QTL-seq approach
Identification of three QTLs that additively affect heading time in bread wheat (Triticum aestivum L.) by QTL-seq approach Open
Optimizing the timing of heading is crucial for achieving stable production in bread wheat (Triticum aestivum L.). We analyzed a breeding line, ‘B1-0393’, that headed 5 days earlier than the Japanese elite cultivar ‘Kitahonami’. To identif…
View article: Identification of the causal mutation in early heading mutant of bread wheat (Triticum aestivum L.) using MutMap approach
Identification of the causal mutation in early heading mutant of bread wheat (Triticum aestivum L.) using MutMap approach Open
View article: Identification of the causal mutation in early heading mutant of bread wheat (Triticumaestivum L.) using MutMap approach
Identification of the causal mutation in early heading mutant of bread wheat (Triticumaestivum L.) using MutMap approach Open
In bread wheat (Triticum aestivum L.), fine-tuning the heading time is essential to maximize grain yield. Photoperiod-1 (Ppd-1) and VERNALIZATION 1 (Vrn-1) are major genes affecting photoperiod sensitivity and vernalization requirements, r…
View article: Genomic diversity of the Japanese wheat core collection and selection of alleles for agronomic traits in the breeding process
Genomic diversity of the Japanese wheat core collection and selection of alleles for agronomic traits in the breeding process Open
Combining high-throughput genotyping data with the latest wheat genomic information provided more detailed information on the genetic diversity of the Japanese wheat core collection (JWC). Analysis of genomic population structure divided t…
View article: Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism
Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism Open
Ubiquitin (Ub) ligases E3 are important factors in selecting target proteins for ubiquitination and determining the type of polyubiquitin chains on the target proteins. In the HECT (homologous to E6AP C-terminus)-type E3 ligases, the HECT …
View article: Natural variations of wheat EARLY FLOWERING 3 highlight their contributions to local adaptation through fine-tuning of heading time
Natural variations of wheat EARLY FLOWERING 3 highlight their contributions to local adaptation through fine-tuning of heading time Open
Heading/flowering at the appropriate time in each cultivation region can greatly contribute to stabilizing and maximizing yield. Genotype combinations of Vrn-1 and Ppd-1 , the major genes determining heading time, can explain the variation…
View article: Mutations within the miR172 target site of wheat <i>AP2</i> homoeologs regulate lodicule size and rachis internode length
Mutations within the miR172 target site of wheat <i>AP2</i> homoeologs regulate lodicule size and rachis internode length Open
Closed fertilization in flowers, or cleistogamy, reduces the risk of fungal infection in Triticeae crops. In barley (Hordeum vulgare), cleistogamy is determined by a single recessive gene, cly1, which results from a single nu…
View article: Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism
Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism Open
Ubiquitin (Ub) ligases E3 are an important factor in selecting target proteins for ubiquitination and determining the type of polyubiquitin chains on the target proteins. In the HECT (homologous to E6AP C-terminus)-type E3 ligases, the HEC…
View article: Genome sequencing-based coverage analyses facilitate high-resolution detection of deletions linked to phenotypes of gamma-irradiated wheat mutants
Genome sequencing-based coverage analyses facilitate high-resolution detection of deletions linked to phenotypes of gamma-irradiated wheat mutants Open
View article: Allelic variations of <i>Vrn-1</i> and <i>Ppd-1</i> genes in Japanese wheat varieties reveal the genotype-environment interaction for heading time
Allelic variations of <i>Vrn-1</i> and <i>Ppd-1</i> genes in Japanese wheat varieties reveal the genotype-environment interaction for heading time Open
The timing of heading is largely affected by environmental conditions. In wheat, Vrn-1 and Ppd-1 have been identified as the major genes involved in vernalization requirement and photoperiod sensitivity, respectively. To comp…
View article: Reference Genome Sequencing and Advances in Genomic Resources in Common Wheat–Chromosome 6B Project in Japan
Reference Genome Sequencing and Advances in Genomic Resources in Common Wheat–Chromosome 6B Project in Japan Open
By successfully sequencing the entire genome of common wheat (Triticum aestivum L.) in 2018, the International Wheat Genome Sequencing Consortium (IWGSC) achieved its goal of publishing the first reference genome sequence of this important…
View article: Multiple Wheat Genomes Reveal Novel Gli-2 Sublocus Location and Variation of Celiac Disease Epitopes in Duplicated α-Gliadin Genes
Multiple Wheat Genomes Reveal Novel Gli-2 Sublocus Location and Variation of Celiac Disease Epitopes in Duplicated α-Gliadin Genes Open
The seed protein α-gliadin is a major component of wheat flour and causes gluten-related diseases. However, due to the complexity of this multigene family with a genome structure composed of dozens of copies derived from tandem and genome …
View article: Genome Sequencing-based Coverage Analyses Facilitate High-resolution Detection of Causal Deletions in Gamma-Irradiated Wheat Mutants
Genome Sequencing-based Coverage Analyses Facilitate High-resolution Detection of Causal Deletions in Gamma-Irradiated Wheat Mutants Open
Background Gamma-irradiated mutants of hexaploid wheat, Triticum aestivum L., have been providing novel and agriculturally important traits and are used for breeding materials. However, identification of causative genomic regions of mutant…
View article: Multiple wheat genomes reveal global variation in modern breeding
Multiple wheat genomes reveal global variation in modern breeding Open
View article: De Novo Genome Assembly of the Japanese Wheat Cultivar Norin 61 Highlights Functional Variation in Flowering Time and<i>Fusarium</i>-Resistant Genes in East Asian Genotypes
De Novo Genome Assembly of the Japanese Wheat Cultivar Norin 61 Highlights Functional Variation in Flowering Time and<i>Fusarium</i>-Resistant Genes in East Asian Genotypes Open
Bread wheat is a major crop that has long been the focus of basic and breeding research. Assembly of its genome has been difficult because of its large size and allohexaploid nature (AABBDD genome). Following the first reported assembly of…
View article: Toward a breakthrough in Triticeae breeding: searching for ways to connect genotype and phenotype
Toward a breakthrough in Triticeae breeding: searching for ways to connect genotype and phenotype Open
View article: Multifamily QTL analysis and comprehensive design of genotypes for high-quality soft wheat
Multifamily QTL analysis and comprehensive design of genotypes for high-quality soft wheat Open
Milling properties and flour color are essential selection criteria in soft wheat breeding. However, high phenotypic screening costs restrict selection to relatively few breeding lines in late generations. To achieve marker-based selection…
View article: Development and characterization of <i>wheat yellow mosaic virus</i>-resistant lines carrying <i>Q.Ymym</i>, breaking off the tightly-linked high-activity allele of the polyphenol oxidase gene in the Japanese wheat variety ‘Yumechikara’
Development and characterization of <i>wheat yellow mosaic virus</i>-resistant lines carrying <i>Q.Ymym</i>, breaking off the tightly-linked high-activity allele of the polyphenol oxidase gene in the Japanese wheat variety ‘Yumechikara’ Open
北海道の超強力秋播きコムギ品種の「ゆめちから」は,コムギ縞萎縮病に対して高度な抵抗性を示し,抵抗性に関与するQTLのQ.Ymymを保有する.Q.Ymymは2D染色体長腕に座乗し,麺色に影響を与える高活性型のポリフェノール酸化酵素(PPO)遺伝子(Ppo-D1b)と強連鎖関係にある.そのため,罹病性品種へのQ.Ymymの導入にはPpo-D1bが伴い,麺の色相低下が問題となっている.本研究は,Ppo-D1bとQ.Ymymの強連鎖を解消し,麺の色相が改善され且つコムギ縞萎縮病抵抗…
View article: A study of Localized Design process for home appliances
A study of Localized Design process for home appliances Open
In the market of home appliances that it is necessary to capture a share of global market. By shifting their production process to localized design, Japanese companies can develop more products in the same amount of time. It means that pro…
View article: A practical design integration method for hierarchical architecture type product system (A lean development process in domestic refrigerator energy saving design with a combination of digital tool, real experiment and humanistic collaboration)
A practical design integration method for hierarchical architecture type product system (A lean development process in domestic refrigerator energy saving design with a combination of digital tool, real experiment and humanistic collaboration) Open
Faced with a changing about global environmental issues, there are great expectations to optimize energy saving design in home appliance products. For effective energy saving design in Refrigeration System, integrated design method is high…
View article: Design method and simulation in airflow control
Design method and simulation in airflow control Open
Airflow control is a technology of room air conditioner, which is a control of indoor airflow temperature and velocity distribution for improving thermal comfort and energy saving performance. Airflow is controlled by airflow direction， vo…
View article: Structural features of two major nucleolar organizer regions (NORs), <i>Nor‐B1</i> and <i>Nor‐B2</i>, and chromosome‐specific rRNA gene expression in wheat
Structural features of two major nucleolar organizer regions (NORs), <i>Nor‐B1</i> and <i>Nor‐B2</i>, and chromosome‐specific rRNA gene expression in wheat Open
Summary The reference genome sequence of wheat ‘Chinese Spring’ (CS) is now available (IWGSC RefSeq v1.0), but the core sequences defining the nucleolar organizer regions (NORs) have not been characterized. We estimated that the total copy…
View article: A New Approach to Maximum Power Point Tracking for Sudden Changes in Irradiance in Photovoltaic Systems
A New Approach to Maximum Power Point Tracking for Sudden Changes in Irradiance in Photovoltaic Systems Open
Background/Objective: This paper presents a new digital control approach to track the Maximum Power Point (MPPT) for Potovoltaic (PV) systems. A photovoltaic power generation system requires an effective controller to overcome sudden chang…
View article: A New Approach to Maximum Power Point Tracking for Sudden Changes in Irradiance in Photovoltaic Systems
A New Approach to Maximum Power Point Tracking for Sudden Changes in Irradiance in Photovoltaic Systems Open
Background/Objective: This paper presents a new digital control approach to track the Maximum Power Point (MPPT) for Potovoltaic (PV) systems. A photovoltaic power generation system requires an effective controller to overcome sudden chang…
View article: Preparation of Polyglycolic Acid Gels for Oral Administration and Their Drug Releasing Behavior
Preparation of Polyglycolic Acid Gels for Oral Administration and Their Drug Releasing Behavior Open
経口投与向けの薬物担体としての利用を目的として，架橋剤に多分岐型のポリエチレングリコール(PEG)，連結剤にピロメリット酸二無水物を用いて，開環付加反応とエステル交換反応によって，ポリグリコール酸(PGA)からゲルを調製した．PGA鎖がゲルの架橋点間外に多く存在するアウターリッチタイプおよび架橋点間内に多く存在するインナーリッチタイプの二種類，使用したPEGが四分岐型のものと三分岐型のものの二種類，そしてPGAの導入率が45，60，75 wt%の三種類から成るゲルを調製した…
View article: Application of Data Analytics and Machine Learning in Mechanical Design Practice
Application of Data Analytics and Machine Learning in Mechanical Design Practice Open
In product development process, we use experiments, 1D calculations, and 3D calculations (3D Computational Fluid Dynamics etc.) to find the design parameters solution that satisfy the performance goal. Product development is a task of tran…
View article: A proposal of load leveling type front loading development using product platform
A proposal of load leveling type front loading development using product platform Open
Faced with a changing about global environmental issues, there are great expectations to optimize energy saving design in home appliance products. Also, variety series design method for mass customization with platform common architecture …
View article: A Lean Development Approach in Domestic RefrigeratorEnergy Saving Design with a combination of Digital tool, Real experiment and Humanistic collaboration.
A Lean Development Approach in Domestic RefrigeratorEnergy Saving Design with a combination of Digital tool, Real experiment and Humanistic collaboration. Open
Faced with a changing about global environmental issues, there are great expectations to optimize energy saving design in home appliance products. For effective energy saving design in Refrigeration System, integrated design method is high…