Lei Chen
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View article: Left atrial-ventricular coupling index associated with new-onset atrial fibrillation in ST-segment elevation myocardial infarction patients
Left atrial-ventricular coupling index associated with new-onset atrial fibrillation in ST-segment elevation myocardial infarction patients Open
LACI is independently associated with the occurrence of NOAF after PCI in patients with STEMI. Incorporating LACI into the analytical model improves its ability to identify patients with higher NOAF risk.
View article: Immune profiling of mpox survivors reveals divergent durability of antibody and T cell responses
Immune profiling of mpox survivors reveals divergent durability of antibody and T cell responses Open
Despite the global spread of mpox virus (MPXV), the durability and breadth of infection-induced immunity remain incompletely defined. Here, we comprehensively characterize MPXV-specific antibody and T cell responses up to 18 months after n…
View article: The microbiological and metabolic traits associated with pT3 colorectal cancer metastasis to lymph nodes
The microbiological and metabolic traits associated with pT3 colorectal cancer metastasis to lymph nodes Open
Introduction Gut microbiota and metabolites play a crucial role in the progression of colorectal cancer. Over half of the CRC patients are at pT3 stage, the presence or absence of regional lymph node metastasis in pT3 patients significantl…
View article: Total knee arthroplasty for hemophilia patients with intramedullary nails via 3D-printed patient-specific instruments: a case report and literature review
Total knee arthroplasty for hemophilia patients with intramedullary nails via 3D-printed patient-specific instruments: a case report and literature review Open
Background: Total knee arthroplasty (TKA) is the mainstay of treatment for end-stage hemophilia arthritis (HA). In patients fitted with femoral intramedullary nails, TKA is more challenging because of the inability to perform femoral intra…
View article: FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway
FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway Open
FGF21 promotes PINK1-mediated mitophagy to attenuate cardiac hypertrophy, and mismatched FGFR1 expression may hamper the beneficial effect of FGF21 on cardiac hypertrophy.
View article: dsHMGB1, released from IL-17A-induced pyroptotic prostate epithelial cells, drives M1 polarization by promoting Pfkp-mediated glycolysis via Jak2/Stat1 transcription in experimental autoimmune prostatitis
dsHMGB1, released from IL-17A-induced pyroptotic prostate epithelial cells, drives M1 polarization by promoting Pfkp-mediated glycolysis via Jak2/Stat1 transcription in experimental autoimmune prostatitis Open
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological disorder in males, characterized by an unknown mechanism and limited therapeutic efficacy. The involvement of high mobility group box 1 (HMGB1…
View article: Influence of a defoaming agent – simethicone – on endoscope cleaning and disinfection: Prospective real-world study
Influence of a defoaming agent – simethicone – on endoscope cleaning and disinfection: Prospective real-world study Open
Simethicone has been extensively utilized in endoscopy examinations and therapies; however, consensus regarding its impact on endoscopy cleaning is still lacking. The aim of this study was to assess impact of simethicone use during endosco…
View article: A novel nomogram for predicting mediastinal lymph node metastasis in non-small cell lung cancer: a retrospective analysis
A novel nomogram for predicting mediastinal lymph node metastasis in non-small cell lung cancer: a retrospective analysis Open
This study presents a dynamic nomogram that integrates EGFR exon 19 deletion and serum ferritin levels, enhancing preoperative staging and aiding treatment decisions for NSCLC patients.
View article: Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT Open
Zinc plays a crucial role in the gut barrier function and are widely used for the prevention of bowel disease. However, the mechanism via which zinc supplementation exerts this regulatory effect is unclear. The present study identifies and…
View article: CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway
CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway Open
Our study elucidates a specific mechanism by which CAF-derived exosomes promote prostate cancer metastasis via miR-196b-5p regulation, contributing to the identification of therapeutic targets for managing tumor metastasis following castra…
View article: Association of <scp>MRI</scp> Left Atrial Strain With Ischemic Stroke in Myocardial Infarction Patients
Association of <span>MRI</span> Left Atrial Strain With Ischemic Stroke in Myocardial Infarction Patients Open
Background Patients with myocardial infarction (MI) have a high risk of ischemic stroke (IS). Left atrial (LA) strain is associated with IS, but the relationship between them remains unclear in patients with MI. Purpose To evaluate the rel…
View article: Real-world treatment of large B-cell lymphoma with chimeric antigen receptor T-cell therapy after loncastuximab tesirine: a plain language summary
Real-world treatment of large B-cell lymphoma with chimeric antigen receptor T-cell therapy after loncastuximab tesirine: a plain language summary Open
What is this summary about? This summary describes an article published in the medical journal eJHaem in September 2024. The article reports a real-world study in which the authors looked at how therapies worked in everyday settings by usi…
View article: Research trends and hotspots of circulating tumor DNA in colorectal cancer: a bibliometric study
Research trends and hotspots of circulating tumor DNA in colorectal cancer: a bibliometric study Open
Introduction Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. The current standard of care for patients with early-stage CRC includes surgical resection and, in select…
View article: Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms
Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms Open
Purpose: Intracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life‐threatening consequences. This study set out to investigate the value of Long noncoding RNA myocardial infarc…
View article: Unipolar potential voltage mapping of bachmann's bundle during different stages of atrial fibrillation: a novel target for ablation therapy?
Unipolar potential voltage mapping of bachmann's bundle during different stages of atrial fibrillation: a novel target for ablation therapy? Open
Background Bachmann’s Bundle (BB) plays an important role in the pathophysiology of atrial fibrillation (AF). Because of its parallel fiber arrangement, BB may be more susceptible to remodeling, which may increase the risk for AF. Low-volt…
View article: Role of lymphocyte-to-C-reactive protein ratio in forecasting microvascular obstruction in ST-segment elevation myocardial infarction post-percutaneous coronary intervention
Role of lymphocyte-to-C-reactive protein ratio in forecasting microvascular obstruction in ST-segment elevation myocardial infarction post-percutaneous coronary intervention Open
Background Current research suggests that microvascular obstruction (MVO) following the first percutaneous coronary intervention (PCI) in myocardial infarction patients is closely related to inflammatory responses. The lymphocyte-to-C-reac…
View article: Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study Open
To evaluate the efficacy and safety of KN026, a novel bispecific HER2 (ECD2 and ECD4) antibody, plus KN046, a PD-L1, and CTLA4 bispecific antibody, in patients with advanced HER2-positive solid tumors. We conducted two sequentially designe…
View article: Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma
Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma Open
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demon…
View article: Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer
Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer Open
Background Prostate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response. Histone modifications play key roles in tumor progression and tre…
View article: Short-term peri- and intra-tumoral CT radiomics to predict immunotherapy response in advanced non-small cell lung cancer
Short-term peri- and intra-tumoral CT radiomics to predict immunotherapy response in advanced non-small cell lung cancer Open
The results demonstrated that a model based on multiple time points outperformed one based on a single time point. The delta-radiomics model has been proved a noninvasive approach for assessing the response of advanced NSCLC patients to im…
View article: Reduced‐volume radiotherapy versus conventional‐volume radiotherapy after induction chemotherapy in nasopharyngeal carcinoma: An open‐label, noninferiority, multicenter, randomized phase 3 trial
Reduced‐volume radiotherapy versus conventional‐volume radiotherapy after induction chemotherapy in nasopharyngeal carcinoma: An open‐label, noninferiority, multicenter, randomized phase 3 trial Open
Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced volume has been proposed. However, …
View article: Association between the ratio of high-density lipoprotein cholesterol to apolipoprotein A-I and in-stent neoatherosclerosis: an optical coherence tomography study
Association between the ratio of high-density lipoprotein cholesterol to apolipoprotein A-I and in-stent neoatherosclerosis: an optical coherence tomography study Open
OCT revealed high HAR levels to be negatively correlated with the incidences of ISNA and TCFA in patients with ISR. HAR is a better indicator of ISNA and plaque fragility than HDL-C itself, thus providing a marker and pathway for better pr…
View article: Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma
Advanced image-identified extranodal extension of retropharyngeal lymph nodes in the refinement of N classification for nasopharyngeal carcinoma Open
Advanced extranodal extension (ENE) in cervical lymph nodes (CLNs) increases the risk of distant metastasis in nasopharyngeal carcinoma (NPC). The 9th NPC staging system classifies N1/N2 patients with advanced CLN ENE as N3 due to similar …