Francisco Amado
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View article: Global disparities in scientific publications: A 5-year analysis of 10 critical care journals
Global disparities in scientific publications: A 5-year analysis of 10 critical care journals Open
View article: CD276 Immature Glycosylation Drives Colorectal Cancer Aggressiveness and T-cell Mediated Immune Escape
CD276 Immature Glycosylation Drives Colorectal Cancer Aggressiveness and T-cell Mediated Immune Escape Open
Colorectal cancer (CRC) progression is fueled by immune evasion, yet the underlying molecular mechanisms remain to be fully characterized. CD276 (B7-H3), an immune checkpoint glycoprotein frequently overexpressed in aggressive tumours, is …
View article: Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged CD-1 male mice
Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged CD-1 male mice Open
View article: Long-Term Exposure to Supraphysiological Levels of Testosterone Impacts Rat Submandibular Gland Proteome
Long-Term Exposure to Supraphysiological Levels of Testosterone Impacts Rat Submandibular Gland Proteome Open
The salivary glands play a central role in the secretion of saliva, whose composition and volume affect oral and overall health. A lesser-explored dimension encompasses the possible changes in salivary gland proteomes in response to fluctu…
View article: Combined Salivary Proteome Profiling and Machine Learning Analysis Provides Insight into Molecular Signature for Autoimmune Liver Diseases Classification
Combined Salivary Proteome Profiling and Machine Learning Analysis Provides Insight into Molecular Signature for Autoimmune Liver Diseases Classification Open
Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are autoimmune liver diseases that target the liver and have a wide spectrum of presentation. A global overview of quantitative variations on the salivary proteome in presenc…
View article: Identification of a potential prognostic panel of biomarkers for stratification of head and neck squamous cell carcinoma based on HPV status and TP53 mutational status
Identification of a potential prognostic panel of biomarkers for stratification of head and neck squamous cell carcinoma based on HPV status and TP53 mutational status Open
View article: Periodontology - New Insights
Periodontology - New Insights Open
Periodontology is a specialized branch of dentistry that deals with the health and diseases of the periodontium, which is the supportive tissue surrounding the teeth. Periodontal diseases are common oral diseases that can affect the teeth …
View article: Tracking Prostate Carcinogenesis over Time through Urine Proteome Profiling in an Animal Model: An Exploratory Approach
Tracking Prostate Carcinogenesis over Time through Urine Proteome Profiling in an Animal Model: An Exploratory Approach Open
Prostate cancer (PCa) is one of the most lethal diseases in men, which justifies the search for new diagnostic tools. The aim of the present study was to gain new insights into the progression of prostate carcinogenesis by analyzing the ur…
View article: Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis
Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis Open
View article: Association Between Estrogen Receptors and GATA3 in Bladder Cancer: A Systematic Review and Meta-Analysis of Their Clinicopathological Significance
Association Between Estrogen Receptors and GATA3 in Bladder Cancer: A Systematic Review and Meta-Analysis of Their Clinicopathological Significance Open
Background Estrogen receptors alpha (ERα) and beta (ERβ) and the cooperating protein GATA-binding factor 3 (GATA3) have been implicated in bladder carcinogenesis and tumour progression. GATA3 and ER have been functionally linked in the est…
View article: Novel exosome biomarker candidates for Alzheimer´s disease unraveled through Mass Spectrometry analysis
Novel exosome biomarker candidates for Alzheimer´s disease unraveled through Mass Spectrometry analysis Open
Exosomes are small extracellular vesicles (EVs) present in human biofluids that can transport specific disease-associated molecules. Consequently blood-derived exosomes have emerged as important peripheral biomarker sources for a wide rang…
View article: The Salivary Secretome
The Salivary Secretome Open
Recently, proteomics has emerged as an important tool for understanding biological systems, protein–protein interactions, and networks that ultimately lead to a deeper understanding of the underlying mechanisms of certain diseases. More re…
View article: Novel exosome biomarker candidates for Alzheimer´s disease unraveled through Mass Spectrometry analysis
Novel exosome biomarker candidates for Alzheimer´s disease unraveled through Mass Spectrometry analysis Open
Background Exosomes are small extracellular vesicles (EVs) present in human biofluids that can carry disease-specific molecules. Blood-derived exosomes emerged as interesting peripheral sources of biomarkers for a wide range of diseases, a…
View article: Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance
Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance Open
The protein quality control network, including autophagy, the proteasome and the unfolded protein response (UPR), is triggered by stress and is overactive in acquired antiestrogen therapy resistance. We show for the first time that the agg…
View article: Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases
Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases Open
Native biofluid peptides offer important information about diseases, holding promise as biomarkers. Particularly, the non-invasive nature of urine sampling, and its high peptide concentration, make urine peptidomics a useful strategy to st…
View article: The role of micropeptides in biology
The role of micropeptides in biology Open
View article: What can urinary exosomes tell us?
What can urinary exosomes tell us? Open
View article: Peptidomics and proteogenomics: background, challenges and future needs
Peptidomics and proteogenomics: background, challenges and future needs Open
With available genomic data and related information, it is becoming possible to better highlight mutations or genomic alterations associated with a particular disease or disorder. The advent of high-throughput sequencing technologies has g…
View article: Insights and clinical potential of proteomics in understanding spermatogenesis
Insights and clinical potential of proteomics in understanding spermatogenesis Open
Introduction: With the worldwide decline on male fertility potential, the importance of the insight of the spermatogenic process has been increasing. In recent years, proteomic methodologies have been applied to seminal fluid of inf…
View article: Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesis
Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesis Open
This review focuses on discussing key mechanisms in disease pathogenesis mediated by the protein post-translational modification citrullination. These processes are discussed in depth in the context of complex diseases such as rheumatoid a…
View article: <i>De novo</i> sequencing of proteins by mass spectrometry
<i>De novo</i> sequencing of proteins by mass spectrometry Open
As mass-spectrometry sequencing performance is improving with better software and hardware optimizations, combined with user-friendly interfaces, de-novo protein sequencing becomes imperative in shotgun proteomic studies. Issues reg…
View article: Top-Down Proteomics of Human Saliva Discloses Significant Variations of the Protein Profile in Patients with Mastocytosis
Top-Down Proteomics of Human Saliva Discloses Significant Variations of the Protein Profile in Patients with Mastocytosis Open
Mastocytosis is a myeloproliferative neoplasm causing abnormal clonal mast cell accumulation in different tissues, such as skin and bone marrow. A cutaneous subtype (CM) is distinguished from a systemic one (SM); SM patients can be grouped…
View article: Taste sensitivity and lifestyle are associated with food preferences and BMI in children
Taste sensitivity and lifestyle are associated with food preferences and BMI in children Open
Oral food perception together with lifestyle may affect food preferences and choices, influencing weight gain and obesity development. The present study was designed to evaluate the association of biological (taste sensitivity) and lifesty…
View article: FGF2 induces breast cancer growth through ligand‐independent activation and recruitment of ERα and PRBΔ4 isoform to <i>MYC</i> regulatory sequences
FGF2 induces breast cancer growth through ligand‐independent activation and recruitment of ERα and PRBΔ4 isoform to <i>MYC</i> regulatory sequences Open
Progression to hormone‐independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone receptors (PR) positive breast cancer. We and others have previou…
View article: Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index
Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index Open
View article: Effects of hyperleptinemia in rat saliva composition, histology and ultrastructure of the major salivary glands
Effects of hyperleptinemia in rat saliva composition, histology and ultrastructure of the major salivary glands Open
View article: Quantitative Proteomic Analysis of Skeletal Muscle Detergent- Resistant Membranes in a Smith-Lemli-Opitz Syndrome Mouse
Quantitative Proteomic Analysis of Skeletal Muscle Detergent- Resistant Membranes in a Smith-Lemli-Opitz Syndrome Mouse Open
Smith-Lemli-Opitz syndrome (SLOS) is an inborn error of metabolism affecting the last step of cholesterol biosynthesis. It is characterized by a deficiency of the enzyme 7-dehydrocholesterol reductase and accumulation of 7-dehydrocholester…
View article: Targeting TNFα in severe psoriasis-mass spectrometry reveals a time-dependent specific inhibition of Factor H in responding patients.
Targeting TNFα in severe psoriasis-mass spectrometry reveals a time-dependent specific inhibition of Factor H in responding patients. Open
Drugs targeting TNFα (eg, Etanercept®) provide effective control of severe psoriasis. In absence of validated biological parameters of inflammation in psoriasis most decisions on therapeutics have relied mostly on clinical criteria, namely…
View article: Relationship between saliva protein composition and 6‐<i>n</i>‐Propylthiouracil bitter taste responsiveness in young adults
Relationship between saliva protein composition and 6‐<i>n</i>‐Propylthiouracil bitter taste responsiveness in young adults Open
6‐ n ‐propylthiouracil (PROP) is widely used in nutritional and health studies. However, only a limited number of studies have compared saliva composition between PROP taster phenotypes. The main aim of this work was to assess the relation…
View article: Association between Salivary Leptin Levels and Taste Perception in Children
Association between Salivary Leptin Levels and Taste Perception in Children Open
The satiety inducing hormone leptin acts not only at central nervous system but also at peripheral level. Leptin receptors are found in several sense related organs, including the mouth. A role of leptin in sweet taste response has been su…