M. Strüber
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View article: Neuronal complexity tracks changes of epileptic activity and identifies epilepsy patients independent of interictal epileptiform discharges
Neuronal complexity tracks changes of epileptic activity and identifies epilepsy patients independent of interictal epileptiform discharges Open
Objective To date, the identification of objective biomarkers of neural epileptic activity (EA) remains challenging. We therefore investigated whether neuronal complexity could serve as an interictal electroencephalographic measure of EA, …
View article: Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis
Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis Open
Our results suggest that RTG treatment might robustly mitigate inflammation-induced altered excitability and preserve ascending information processing.
View article: Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience
Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience Open
Experience-driven alterations in neuronal activity are followed by structural-functional modifications allowing cells to adapt to these activity changes. Structural plasticity has been observed for cortical principal cells. However, how GA…
View article: Determinants of quality of life in adults with epilepsy: a multicenter, cross-sectional study from Germany
Determinants of quality of life in adults with epilepsy: a multicenter, cross-sectional study from Germany Open
Background Assessment of quality of life (QoL) has become an important indicator for chronic neurological diseases. While these conditions often limit personal independence and autonomy, they are also associated with treatment-related prob…
View article: Spine dynamics of dentate gyrus parvalbumin-positive interneurons are defined by network activity and experience
Spine dynamics of dentate gyrus parvalbumin-positive interneurons are defined by network activity and experience Open
Parvalbumin-positive interneurons (PVIs) in the dentate gyrus (DG) possess dendritic spines, but their functional properties and structural dynamics remain uncharted. Using in vitro 2-Photon imaging, we show that glutamatergic synapses at …
View article: Repetitive Electroencephalography as Biomarker for the Prediction of Survival in Patients with Post-Hypoxic Encephalopathy
Repetitive Electroencephalography as Biomarker for the Prediction of Survival in Patients with Post-Hypoxic Encephalopathy Open
Predicting survival in patients with post-hypoxic encephalopathy (HE) after cardiopulmonary resuscitation is a challenging aspect of modern neurocritical care. Here, continuous electroencephalography (cEEG) has been established as the gold…
View article: Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice Open
The local field potential (LFP) emerges from ion movements across neural membranes. Since the voltage recorded by LFP electrodes reflects the summed electrical field of a large volume of brain tissue, extracting information about local act…
View article: Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus
Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus Open
Gamma oscillations (30–150 Hz) in neuronal networks are associated with the processing and recall of information. We measured local field potentials in the dentate gyrus of freely moving mice and found that gamma activity occurs in bursts,…
View article: Impaired fast-spiking interneuron function in a genetic mouse model of depression
Impaired fast-spiking interneuron function in a genetic mouse model of depression Open
Rhythmic neuronal activity provides a frame for information coding by co-active cell assemblies. Abnormal brain rhythms are considered as potential pathophysiological mechanisms causing mental disease, but the underlying network defects ar…
View article: Author response: Impaired fast-spiking interneuron function in a genetic mouse model of depression
Author response: Impaired fast-spiking interneuron function in a genetic mouse model of depression Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Rhythmic neuronal activity provides a frame for…
View article: Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells
Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells Open
Significance The activity dynamics of cortical circuits are directly determined by the composing cells and their connections. Inhibitory interneurons are important regulators of neuronal network function. However, how the functional proper…