Francesco Montorsi
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View article: The global burden of kidney cancer: trends in mortality and incidence with predictions to 2025
The global burden of kidney cancer: trends in mortality and incidence with predictions to 2025 Open
Over the past three decades, the incidence of kidney cancer has been increasing worldwide. Mortality trends, however, differed over time and across regions, showing downward trends in most high-income countries, but upward trends mainly in…
View article: Best therapeutic approach in metastatic hormone-sensitive prostate cancer based on disease volume: a systematic review and network meta-analysis
Best therapeutic approach in metastatic hormone-sensitive prostate cancer based on disease volume: a systematic review and network meta-analysis Open
CONTEXT With new treatment strategies approved in metastatic hormone-sensitive prostate cancer (mHSPC), heterogeneity across trials hinders the physicians’ choice for first-line treatment. OBJECTIVE We conducted a systematic review and net…
View article: Patient-Reported Outcome Measures in Individuals With Hereditary or Sporadic Kidney Cancer: A Comparative Study of Depression and Sexual Function
Patient-Reported Outcome Measures in Individuals With Hereditary or Sporadic Kidney Cancer: A Comparative Study of Depression and Sexual Function Open
PURPOSE Von Hippel-Lindau (VHL) disease is a rare genetically inherited disorder and represents the most frequent cause of hereditary renal cancer (RC). Depression and quality of life (QoL) are often neglected or underreported issues in in…
View article: #2769 Impact of body mass index (BMI) on renal function decline in high-risk renal cell carcinoma: implications for first-line systemic therapy eligibility
#2769 Impact of body mass index (BMI) on renal function decline in high-risk renal cell carcinoma: implications for first-line systemic therapy eligibility Open
Background and Aims For patients at high risk of systemic progression following surgery for renal cancer, several systemic therapies are available. However, an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m² often serve…
View article: #1447 Pre-operative CKD stages IIIb–IV in renal cancer surgery: are AKI and ESRD inevitable? Insights from real-life experience
#1447 Pre-operative CKD stages IIIb–IV in renal cancer surgery: are AKI and ESRD inevitable? Insights from real-life experience Open
Background and Aims Chronic kidney disease (CKD) is a global health challenge, especially in renal surgery, where preserving kidney function while ensuring oncological safety is crucial. Partial nephrectomy (PN) is preferred over radical n…
View article: Assessing the oncologic risk when systematic and multiparametric magnetic resonance imaging–targeted prostate biopsy grade groups are discordant
Assessing the oncologic risk when systematic and multiparametric magnetic resonance imaging–targeted prostate biopsy grade groups are discordant Open
Background In the systematic biopsy era, prostate biopsy grading followed the rule that the International Society of Urological Pathology grade group assigned was the highest grade group of any core. This rule has been retained in the era …
View article: A Narrative Review of Treatment Options for Patients with Node-Positive Disease After Radical Prostatectomy: Current Evidence and Controversies
A Narrative Review of Treatment Options for Patients with Node-Positive Disease After Radical Prostatectomy: Current Evidence and Controversies Open
Purpose of Review: In approximately 10–15% of patients with prostate cancer (PCa), pathological lymph node metastases (pN1) are detected at radical prostatectomy (RP). The aim of this review is to describe the various treatment options for…
View article: Detectable prostate‐specific antigen after radiotherapy for clinically localized prostate cancer
Detectable prostate‐specific antigen after radiotherapy for clinically localized prostate cancer Open
Background This study assesses the incidence and timing of undetectable prostate‐specific antigen (PSA) after radiotherapy (RT) ± androgen deprivation therapy (ADT) and its association with prostate cancer mortality. Methods This is a popu…
View article: The Impact of Neoadjuvant Chemotherapy on Cancer Specific Mortality in Patients With Upper Tract Urothelial Carcinoma: A Retrospective Analysis of an Other Cause Mortality Risk Matched Cohort
The Impact of Neoadjuvant Chemotherapy on Cancer Specific Mortality in Patients With Upper Tract Urothelial Carcinoma: A Retrospective Analysis of an Other Cause Mortality Risk Matched Cohort Open
Purpose: Although neoadjuvant chemotherapy (NAC) may benefit upper tract urothelial carcinoma (UTUC) treatment, most studies are retrospective and affected by selection bias, as healthier patients are more likely to receive NAC. We therefo…
View article: Acute Kidney Injury (AKI) and End Stage Kidney Disease (ESKD) in CKD Patients Undergoing Partial or Radical Nephrectomy for Renal Cancer: Are We Ready to Unravel the Uncertainty and Create New Hope?
Acute Kidney Injury (AKI) and End Stage Kidney Disease (ESKD) in CKD Patients Undergoing Partial or Radical Nephrectomy for Renal Cancer: Are We Ready to Unravel the Uncertainty and Create New Hope? Open
Background and Objective: Patients with moderate to severe preoperative chronic kidney disease (CKD) are often considered at high risk for postoperative acute kidney injury (AKI) and progression to end-stage kidney disease (ESKD), especial…
View article: Testis Molecular Pathways in CAIS Unveil Testosterone/Estradiol on Germ Cell Tumor Risk in Non-Obstructive Azoospermia
Testis Molecular Pathways in CAIS Unveil Testosterone/Estradiol on Germ Cell Tumor Risk in Non-Obstructive Azoospermia Open
Context Non-obstructive azoospermia (NOA) is the most severe form of male infertility, affecting 1% of all men, with a clinical picture characterized by no sperm production, hyalinization of the basal membrane of the seminiferous tubules, …
View article: Impact of <scp>three‐dimensional</scp> prostate models during robot‐assisted radical prostatectomy on surgical margins and functional outcomes
Impact of <span>three‐dimensional</span> prostate models during robot‐assisted radical prostatectomy on surgical margins and functional outcomes Open
Background Robot‐assisted radical prostatectomy (RARP) is the standard surgical procedure for the treatment of prostate cancer. RARP requires a trade‐off between performing a wider resection in order to reduce the risk of positive surgical…
View article: Pathological Affective Dependence as a Risk Factor for Intimate Partner Violence: Initial Psychometric Validation of the Italian Version of the Pathological Affective Dependence Scale
Pathological Affective Dependence as a Risk Factor for Intimate Partner Violence: Initial Psychometric Validation of the Italian Version of the Pathological Affective Dependence Scale Open
Purpose This study aimed to validate the Italian version of the Pathological Affective Dependence Scale (PADS), which assesses both trait and state manifestations of Pathological Affective Dependence (PAD), a key risk factor for Intimate P…
View article: Correction: High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1
Correction: High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1 Open
[This corrects the article DOI: 10.3389/fonc.2025.1590073.].
View article: Positive Surgical Margins in Clear Cell Renal Cell Carcinoma: Prognostic Impact and Implications for Risk Stratification and Adjuvant Therapy
Positive Surgical Margins in Clear Cell Renal Cell Carcinoma: Prognostic Impact and Implications for Risk Stratification and Adjuvant Therapy Open
Objectives: To evaluate the prognostic impact of positive surgical margins (PSMs) after partial or radical nephrectomy for clear cell renal cell carcinoma (ccRCC) across AJCC stages and assess its relevance to adjuvant therapy eligibility,…
View article: Magnetic resonance imaging for long‐term active surveillance biopsy decision‐making
Magnetic resonance imaging for long‐term active surveillance biopsy decision‐making Open
Objectives To evaluate whether long‐term magnetic resonance imaging (MRI) findings, alone or in combination with prostate‐specific antigen (PSA) density or the result of prior surveillance biopsies, could be used to omit biopsies occurring…
View article: High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1
High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1 Open
Objective Urothelial carcinoma (UC) accounts for more than 90% of all bladder cancers both in humans and dogs. Human and canine UC share many genetic mutations and tumor markers and clinical and therapeutic interventions. The unmet clinica…
View article: Establishing the role of single‐stage preputial spiral graft urethroplasty for panurethral stricture
Establishing the role of single‐stage preputial spiral graft urethroplasty for panurethral stricture Open
Objective To assess whether single‐stage preputial spiral graft urethroplasty (PSGU) minimises panurethral stricture (PUS) recurrence, which often result from traditional multiple grafting for anterior urethral strictures exceeding 10 cm. …
View article: Contemporary outcomes in non‐muscle‐invasive bladder cancer: a large European multicentre study
Contemporary outcomes in non‐muscle‐invasive bladder cancer: a large European multicentre study Open
Objective To report real‐world rates of non‐muscle‐invasive bladder cancer (NMIBC) recurrence and progression within a European multicentre cohort with detailed information on intravesical instillation courses, as contemporary data on onco…
View article: Low testosterone in primary infertile men is associated with a history of maternal obesity during pregnancy: Findings from a cross‐sectional study
Low testosterone in primary infertile men is associated with a history of maternal obesity during pregnancy: Findings from a cross‐sectional study Open
Background Maternal obesity increases offspring obesity risk, but limited data exist on its association with reproductive hormones in infertile males. Objectives To investigate the impact of maternal obesity during pregnancy on total testo…
View article: THE IMPACT OF EDUCATIONAL STATUS ON PATIENTS COMPLIANCE WITH PDE5IS: A COMPARATIVE CROSS-SECTIONAL REAL-LIFE STUDY
THE IMPACT OF EDUCATIONAL STATUS ON PATIENTS COMPLIANCE WITH PDE5IS: A COMPARATIVE CROSS-SECTIONAL REAL-LIFE STUDY Open
Objectives The impact of educational status on patients’ compliance regarding prescribed phosphodiesterase type 5 inhibitors (PDE5is) in men with erectile dysfunction (ED) has been scantly analysed. We investigated the impact of educationa…
View article: CLINICAL PREDICTORS OF RESPONSE TO PHOSPHODIESTERASE TYPE 5 INHIBITOR (PDE5IS) THERAPY IN PATIENTS WITH ERECTILE DYSFUNCTION: A PENILE HEMODYNAMIC STUDY
CLINICAL PREDICTORS OF RESPONSE TO PHOSPHODIESTERASE TYPE 5 INHIBITOR (PDE5IS) THERAPY IN PATIENTS WITH ERECTILE DYSFUNCTION: A PENILE HEMODYNAMIC STUDY Open
Objectives Phosphodiestrase-5 inhibitors (PDE5is) are the mainstay of treatment for erectile dysfunction (ED), yet the influence of patients’ clinical characteristics and penile Color Doppler Duplex Ultrasounds (CDDU) parameters on PDE5is’…
View article: DETERMINANTS OF FOLLOW-UP VISIT RATES IN PATIENTS YOUNGER THAT 40 YEARS OF AGE PRESENTING FOR ERECTILE DYSFUNCTION: INSIGHTS FROM A LARGE COHORT REAL-LIFE STUDY
DETERMINANTS OF FOLLOW-UP VISIT RATES IN PATIENTS YOUNGER THAT 40 YEARS OF AGE PRESENTING FOR ERECTILE DYSFUNCTION: INSIGHTS FROM A LARGE COHORT REAL-LIFE STUDY Open
Objectives Erectile dysfunction (ED) is increasingly recognized in patients under 40 years. Follow-up rates in this demographic remain underexplored. Understanding the frequency of return visits for follow-up is crucial to tailor effective…
View article: PREDICTIVE VALUE OF 5 MINUTES PEAK SYSTOLIC VELOCITY AND LIFESTYLE FACTORS IN ASSESSING PATHOLOGICAL DYNAMIC COLOUR DOPPLER DUPLEX ULTRASOUND OUTCOMES IN PATIENTS WITH ERECTILE DYSFUNCTION
PREDICTIVE VALUE OF 5 MINUTES PEAK SYSTOLIC VELOCITY AND LIFESTYLE FACTORS IN ASSESSING PATHOLOGICAL DYNAMIC COLOUR DOPPLER DUPLEX ULTRASOUND OUTCOMES IN PATIENTS WITH ERECTILE DYSFUNCTION Open
Objectives The role of penile dynamic colour Doppler duplex ultrasound (CDDU) is debated throughout the diagnostic work-up of men with erectile dysfunction (ED). The association between ED and lifestyle’s habits has been studied in literat…
View article: REDUCING DIAGNOSTIC AND TREATMENT DELAYS IN PENILE CANCER: A CALL FOR IMPROVED REFERRAL SYSTEMS
REDUCING DIAGNOSTIC AND TREATMENT DELAYS IN PENILE CANCER: A CALL FOR IMPROVED REFERRAL SYSTEMS Open
Objectives Penile cancer (PeCa) is often stigmatized by patients and their families, leading to delays in diagnosis. Timely referral is essential for improving outcomes. We aimed to examine the critical link between the time frame from the…
View article: NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A NOVEL MARKER OF ERECTILE DYSFUNCTION BURDEN: FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY
NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A NOVEL MARKER OF ERECTILE DYSFUNCTION BURDEN: FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY Open
Objectives The neutrophil-to-lymphocyte ratio (NLR) is an indicator of systemic inflammation in various pathological conditions. Data regarding its role as marker of endothelial dysfunction in erectile dysfunction (ED) have been scantily a…
View article: The Role of Robot-Assisted, Imaging-Guided Surgery in Prostate Cancer Patients
The Role of Robot-Assisted, Imaging-Guided Surgery in Prostate Cancer Patients Open
Emerging imaging-guided technologies, such as prostate-specific membrane antigen radioguided surgery (PSMA-RGS) and augmented reality (AR), could enhance the precision and efficacy of robot-assisted prostate cancer (PCa) surgical approache…
View article: Efficacy of a Low-Cost Weight-Bearing Sensitivity Incentivator After Lower Limb Surgery
Efficacy of a Low-Cost Weight-Bearing Sensitivity Incentivator After Lower Limb Surgery Open
Accurate adherence to partial weight-bearing instructions is critical for successful rehabilitation after lower limb surgery, yet traditional training methods often fail to ensure consistent patient compliance. This study evaluates the eff…