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Implicit social animations lead to distinct changes of dopaminergic, corticostriatal and thalamocortical functional connectivity in schizophrenia and bipolar disorder Open
The unique patterns of altered connectivity in SCZ (imbalance between striatothalamic and thalamocortical connectivity), and BPD, while sharing a common pattern of increase between VTA and dorsal striatum, may represent candidate biomarker…
View article: Changes in the endoplasmic reticulum‑mitochondria communication in dermal fibroblasts from early‑stage bipolar disorder patients: Skin‑brain axis as a new route to understand the pathophysiology of mental illness?
Changes in the endoplasmic reticulum‑mitochondria communication in dermal fibroblasts from early‑stage bipolar disorder patients: Skin‑brain axis as a new route to understand the pathophysiology of mental illness? Open
Compromised cellular resilience in bipolar disorder (BD) has been associated with structural brain changes and cognitive deficits caused by perturbation of redox status, endoplasmic reticulum (ER) stress and innate immunity. These crucial …
View article: Uric Acid in First-Episode Psychosis: A Systematic Review
Uric Acid in First-Episode Psychosis: A Systematic Review Open
Background: Psychotic disorders such as schizophrenia (SCZ) have been frequently linked with oxidative stress, with uric acid (UA) levels being of particular interest, although evidence remains inconclusive. A possible reduction of UA leve…
View article: Neuromodulation in the treatment of social cognition dysfunction in Schizophrenia: a systematic review
Neuromodulation in the treatment of social cognition dysfunction in Schizophrenia: a systematic review Open
Neuromodulation techniques improved some domains of social cognition in individuals with schizophrenia. Further research is required to develop robust treatment protocols with proven efficacy in improving social cognition.
View article: Attention Deficit/Hyperactivity Disorder in Adults: Position of Portuguese Experts on Diagnosis and Treatment
Attention Deficit/Hyperactivity Disorder in Adults: Position of Portuguese Experts on Diagnosis and Treatment Open
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood, affecting approximately 1.5% - 3% of the adult population in Portugal. Untreated ADHD in adults is associated with increas…
View article: Comorbidity, Treatment, and Service Utilization Patterns in Difficult-to-Treat Depression Patients: A Retrospective Study in a Portuguese Community Mental Health Team
Comorbidity, Treatment, and Service Utilization Patterns in Difficult-to-Treat Depression Patients: A Retrospective Study in a Portuguese Community Mental Health Team Open
Background and Objectives: Observational studies with data from real-world clinical practice with patients with difficult-to-treat depression (DTD) are rare. This study aims to collect observational data from the real-world clinical practi…
View article: Improving Access to Mental Health Care through a Stepped Care Approach: Preliminary Results from a University Students’ Sample
Improving Access to Mental Health Care through a Stepped Care Approach: Preliminary Results from a University Students’ Sample Open
Introduction: Recently, university counseling services have been faced with an increasing number of students seeking psychological support. However, human resources and time constraints limit the services to respond adequately. Recently, n…
View article: Proteomic analysis of peripheral blood mononuclear cells in first episode psychosis – Protein and peptide-centered approaches to elucidate potential diagnostic biomarkers
Proteomic analysis of peripheral blood mononuclear cells in first episode psychosis – Protein and peptide-centered approaches to elucidate potential diagnostic biomarkers Open
Diagnosing patients suffering from psychotic disorders is far from being achieved with molecular support, despite all the efforts to study these disorders from different perspectives. Characterizing the proteome of easily obtainable blood …
View article: European Autism GEnomics Registry (EAGER): protocol for a multicentre cohort study and registry
European Autism GEnomics Registry (EAGER): protocol for a multicentre cohort study and registry Open
Introduction Autism is a common neurodevelopmental condition with a complex genetic aetiology that includes contributions from monogenic and polygenic factors. Many autistic people have unmet healthcare needs that could be served by genomi…
View article: Frotteurism and Kleptomania in High-Functioning Autism Spectrum Disorder: A Case Report
Frotteurism and Kleptomania in High-Functioning Autism Spectrum Disorder: A Case Report Open
Innate vulnerabilities in autism spectrum disorder (ASD) could increase the risk of comorbid psychiatric conditions and judicial problems. Persistent deficits in social communication, narrow, repetitive interests, or sensory impairments co…
View article: European Autism GEnomics Registry (EAGER): Protocol for a multicentre cohort study and registry
European Autism GEnomics Registry (EAGER): Protocol for a multicentre cohort study and registry Open
Introduction Autism is a common neurodevelopmental condition with a complex genetic aetiology that includes contributions from monogenic and polygenic factors. Many autistic people have unmet healthcare needs that could be served by genomi…
View article: Emotional interference and attentional control in schizophrenia-spectrum disorders: The special case of neutral faces
Emotional interference and attentional control in schizophrenia-spectrum disorders: The special case of neutral faces Open
One possible explanation is that neutral faces captured exogenous attention to a greater extent in SSD, thus challenging attentional control in perceptually demanding conditions. This may reflect abnormal processing of neutral faces in SSD…
View article: Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder Open
Background: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overl…
View article: Editorial: Neuroimaging in early intervention in psychiatry
Editorial: Neuroimaging in early intervention in psychiatry Open
EDITORIAL article Front. Psychiatry, 05 May 2023Sec. Neuroimaging Volume 14 - 2023 | https://doi.org/10.3389/fpsyt.2023.1196886
View article: Perinatal depressive symptoms in Portuguese new fathers and mothers during COVID-19 pandemic
Perinatal depressive symptoms in Portuguese new fathers and mothers during COVID-19 pandemic Open
Introduction Postpartum depression, refers to depressive symptoms within a 12-month period after the birth of an infant in a new father or mother . It’s have been a growing mental health concern, as it is one of the leading causes of poor …
View article: Psychological burden in Portuguese university students during the COVID-19 pandemic
Psychological burden in Portuguese university students during the COVID-19 pandemic Open
Background: University students are a risk population for mental health problems. This study aims to evaluate the psychological burden of the COVID-19 pandemic in Portuguese university students and to uncover factors associated with worse …
View article: Neuroimaging in Internet gaming disorder comorbid with Attention-deficit disorder
Neuroimaging in Internet gaming disorder comorbid with Attention-deficit disorder Open
Introduction Internet gaming disorder (IGD) refers to a pattern of persistent gambling behaviour or recurring gambling, on the Internet, with impaired control, increased priority, and continuation or escalation of gambling despite the occu…
View article: Emotional interference and attentional control in schizophrenia-spectrum disorders: The special case of neutral faces
Emotional interference and attentional control in schizophrenia-spectrum disorders: The special case of neutral faces Open
Background and Objectives. Schizophrenia-spectrum disorders (SSD) are characterized by impaired emotion processing and attention. SSD patients are more sensitive to the presence of emotional distractors. But despite growing interest on the…
View article: The Impact of COVID-19 on Anxious and Depressive Symptomatology in the Postpartum Period
The Impact of COVID-19 on Anxious and Depressive Symptomatology in the Postpartum Period Open
Background: Women in the postpartum period may be particularly vulnerable to the psychological effects of the COVID-19 pandemic. The aim of our study was to evaluate the impact of the coronavirus pandemic on postpartum depression and anxie…
View article: The Portuguese adapted version of the fear of covid-19 scale for the postpartum period
The Portuguese adapted version of the fear of covid-19 scale for the postpartum period Open
Introduction The Portuguese version of the Fear of COVID-19 Scale (FCV-19S; Cabaços et al. 2021), composed of seven items, presented good validity and reliability to be used in general population. To be used within perinatal context, speci…
View article: Grief during the COVID-19 pandemic: A cross-sectional online survey in university students
Grief during the COVID-19 pandemic: A cross-sectional online survey in university students Open
Introduction Almost 5 million people worldwide have lost their lives due to SARS-CoV-2 (source: WHO coronavirus (COVID-19) dashboard, data of 1.10.2021; https://covid19.who.int/ ) and therefore, globally, there is an increase of people in …
View article: Epileptic Seizures or not, that is the question: a case report
Epileptic Seizures or not, that is the question: a case report Open
Introduction Psychogenic nonepileptic seizures (PNES) consist of paroxysmal changes in responsiveness, movements, or behaviour that superficially resemble epileptic seizures. Objectives Presentation of a clinical case of a PNES in a patien…
View article: Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder
Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder Open
Bipolar disorder (BD) is a clinically heterogeneous condition, presenting a complex underlying etiopathogenesis that is not sufficiently characterized. Without molecular biomarkers being used in the clinical environment, several large scre…
View article: Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia
Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia Open
Mass spectrometry (MS)-based techniques can be a powerful tool to identify neuropsychiatric disorder biomarkers, improving prediction and diagnosis ability. Here, we evaluate the efficacy of MS proteomics applied to human peripheral fluids…
View article: Portuguese Version of the Stigma Scale: Preliminary Psychometric Characteristics
Portuguese Version of the Stigma Scale: Preliminary Psychometric Characteristics Open
Introduction: Stigma is associated with poor prognosis of illness and reduced help-seeking behavior, self-esteem and treatment compliance. The aims of this study were to study the reliability and construct validity of the King’s et al Stig…
View article: Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes
Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes Open
Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is a crucial component of the cellular machinery responsible for Ca2+ homeostasis. The selective inhibition of SERCA by thapsigargin (TG) leads to perturbations in Ca2+ signaling, which can t…