F. Michael Cutrer
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View article: The Neurogenic Basis of Migraine
The Neurogenic Basis of Migraine Open
There is accumulating evidence of a neurogenic basis of migraine. This evidence arises from both the clinical and experimental domains. Many of the well known clinical features of migraine attacks including the prodrome are not explained b…
View article: Imaging Findings of Migraine
Imaging Findings of Migraine Open
Increasingly sophisticated neuroimaging techniques have allowed researchers to begin to define functional and anatomical characteristics of migraine. This paper reviews current knowledge and techniques employed. Assessing present‐day knowl…
View article: Mechanisms of migraine aura revealed by functional MRI in human visual cortex
Mechanisms of migraine aura revealed by functional MRI in human visual cortex Open
Cortical spreading depression (CSD) has been suggested to underlie migraine visual aura. However, it has been challenging to test this hypothesis in human cerebral cortex. Using high-field functional MRI with near-continuous recording duri…
View article: Non‐NMDA glutamate receptors modulate capsaicin induced c‐<i>fos</i> expression within trigeminal nucleus caudalis
Non‐NMDA glutamate receptors modulate capsaicin induced c‐<i>fos</i> expression within trigeminal nucleus caudalis Open
We examined the effects of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)/kainate receptor antagonists 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX) and 1,2,3,4‐tetrahydro‐6‐nitro‐2,3‐dioxo‐benzol[f]quinoxaline‐7‐sulphonamid…
View article: Attenuation by valproate of c‐fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin
Attenuation by valproate of c‐fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin Open
1. Valproic acid, useful in the treatment of migraine, is an inhibitor of gamma aminobutyric acid (GABA) aminotransferase and activator of glutamic acid decarboxylase. Its mechanism in migraine remains obscure. The effects of valproic acid…
View article: Peripheral GABA<sub>A</sub> receptor‐mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation
Peripheral GABA<sub>A</sub> receptor‐mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation Open
The GABA transaminase inhibitor and activator of glutamic acid decarboxylase, valproic acid is being used for the treatment of migraine. Its mechanism of action is unknown. We tested the effects of sodium valproate and GABA A ‐agonist musc…
View article: Suppression by the sumatriptan analogue, CP‐122,288 of c‐fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin
Suppression by the sumatriptan analogue, CP‐122,288 of c‐fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin Open
The effects of an intravenously administered sumatriptan analogue were examined on c‐fos‐like immunoreactivity (c‐fos‐LI), a marker of neuronal activation, evoked within trigeminal nucleus caudalis (TNC) and other brain stem regions 2 h af…