Giancarlo Ruocco
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View article: Cell wall–derived mechanical signals control cell growth and division during root development
Cell wall–derived mechanical signals control cell growth and division during root development Open
Organogenesis emerges from the interplay between genetic and physical interactions within a growing cellular system. While numerous studies have explored how genetic and molecular networks regulate cell activity, the impact of physical int…
View article: Evidence of scaling regimes in the hopfield dynamics of whole brain model
Evidence of scaling regimes in the hopfield dynamics of whole brain model Open
It is shown that the activity of a whole-brain model based on a Hopfield recurrent neural network exhibits a scaling regime whose exponents depend on both the number of parcels and the decay length of the coupling strength. This scaling re…
View article: The recurrent Hopfield mass model: Scalability and optimization
The recurrent Hopfield mass model: Scalability and optimization Open
The Recurrent Hopfield Mass Model (RHoMM) is a novel generative model developed for the estimation of large-scale effective connectivity from magnetoencephalography (MEG) Band Limited Power signals. This binary mass model, compared to the …
View article: Investigating the Structural Basis of Diacetyl Recognition by the G-Protein-Coupled Receptor ODR-10 in <i>Caenorhabditis elegans</i>
Investigating the Structural Basis of Diacetyl Recognition by the G-Protein-Coupled Receptor ODR-10 in <i>Caenorhabditis elegans</i> Open
G-protein-coupled receptors (GPCRs) are among the most versatile molecular sensors in biology, capable of sensing and responding to a wide range of molecules and serving as key targets in drug discovery. In Caenorhabditis elegans, the GPCR…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity an…
View article: A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies
A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies Open
We develop a mother machine-like microfluidic device specifically designed to track the proliferation of T-cells via live-cell microscopy. Although numerous microfluidic setups have been developed to study cell proliferation at the single-…
View article: Internal Stresses as Origin of the Anomalous Low-Temperature Specific Heat in Glasses
Internal Stresses as Origin of the Anomalous Low-Temperature Specific Heat in Glasses Open
We apply a recently developed theory of the nonphononic vibrational density of states (DOS) in glasses to investigate the impact of local frozen-in stresses on the low-temperature specific heat. Using a completely harmonic description we s…
View article: Further testing the validity of generalized heterogeneous-elasticity theory for low-frequency excitations in structural glasses
Further testing the validity of generalized heterogeneous-elasticity theory for low-frequency excitations in structural glasses Open
In a recent paper E. Lerner and E. Bouchbinder, Phys. Rev. E {\bf 111}, L013402 (2025) raised concerns regarding the validity of the theory and the interpretation of the data, presented in our previous study on non-phononic vibrational exc…
View article: Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells
Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells Open
Mechanical alterations of protein condensates are increasingly recognized in the etiology of several neurodegenerative diseases, yet their characterization remains technically challenging. Although Brillouin microscopy could offer a promis…
View article: Engineering a microfluidic-assisted 3D bioprinting approach for the hierarchical control deposition and compartmentalisation of graded bioinks
Engineering a microfluidic-assisted 3D bioprinting approach for the hierarchical control deposition and compartmentalisation of graded bioinks Open
The advent of 3D bioprinting has revolutionized tissue engineering and regenerative medicine. Today, tissues of single cell type can be fabricated with extreme resolution and printing fidelity. However, the ultimate functionality of the de…
View article: Exotic collective dynamics in molten Carbon
Exotic collective dynamics in molten Carbon Open
Collective longitudinal and transverse propagating modes in molten Carbon at $T=5500$~K and pressure range $10$-$40$ GPa are reported from {\it ab initio} based as well as machine learned molecular dynamics. A striking exotic feature in co…
View article: Aqueous two-phase bioinks for discrete packing and compartmentalisation of 3D bioprinted cells
Aqueous two-phase bioinks for discrete packing and compartmentalisation of 3D bioprinted cells Open
The unparalleled ability of aqueous two-phase systems (ATPS) to reproduce microscale cellular and biomaterial compartmentalisation to selectively modulate cell behaviour and functionality is ideal for tissue engineering and regenerative me…
View article: Insights into the role of dynamical features in protein complex formation: the case of SARS-CoV-2 spike binding with ACE2
Insights into the role of dynamical features in protein complex formation: the case of SARS-CoV-2 spike binding with ACE2 Open
The functionality of protein-protein complexes is closely tied to the strength of their interactions, making the evaluation of binding affinity a central focus in structural biology. However, the molecular determinants underlying binding a…
View article: Transverse collective excitations in liquids: Is the phonon theory of liquid thermodynamics correct?
Transverse collective excitations in liquids: Is the phonon theory of liquid thermodynamics correct? Open
Nonhydrodynamic transverse excitations in liquids exhibit a propagation gap in the long-wavelength region of their dispersion curve. Using molecular dynamics simulations, we investigate the density dependence of the propagation gap width i…
View article: Rosette formations as symmetry-breaking events: theory and experiment
Rosette formations as symmetry-breaking events: theory and experiment Open
Multicellular rosettes are observed in different situations such as morphogenesis, wound healing, and cancer progression. While some molecular insights have been gained to explain the presence of these assemblies of five or more cells arou…
View article: Probing phased-array focused ultrasound transducers using realistic 3D in-silico trabecular skull models: A numerical study
Probing phased-array focused ultrasound transducers using realistic 3D in-silico trabecular skull models: A numerical study Open
Transcranial focused ultrasound (tFUS) is an emerging neuromodulation technology with transformative potential for brain disease therapies. This study explores how the trabecular structure of the human skull affects the performance of mult…
View article: Modelling, simulation, and experimental characterization of particle sedimentation inside a horizontal syringe
Modelling, simulation, and experimental characterization of particle sedimentation inside a horizontal syringe Open
Sedimentation is the settling of solid particles in a liquid medium driven by gravity. This phenomenon poses significant challenges in experimental lab-on-chip (LOC) applications, as they often involve a biological sample to be loaded insi…
View article: Non-Invasive Screening of Alzheimer’s Disease via Label-Free Multispectral Retinal Imaging
Non-Invasive Screening of Alzheimer’s Disease via Label-Free Multispectral Retinal Imaging Open
Alzheimer’s disease (AD) is the most prevalent form of dementia, yet its early detection remains challenging due to the invasiveness, cost, and limited accessibility of current diagnostics. Increasing evidence suggests that retinal changes…
View article: Multiphoton quantum simulation of the generalized Hopfield memory model
Multiphoton quantum simulation of the generalized Hopfield memory model Open
In the present work, we introduce, develop, and investigate a connection between multiphoton quantum interference, a core element of emerging photonic quantum technologies, and Hopfieldlike Hamiltonians of classical neural networks, the pa…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity an…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent works suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity a…