Jean‐François Moreau
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View article: Widespread non-adherence to guidelines in the operative management of diabetes-related foot disease complications
Widespread non-adherence to guidelines in the operative management of diabetes-related foot disease complications Open
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View article: Influence of Splenomegaly and Splenectomy on the Immune-Cell Profile of Patients with Common Variable Immunodeficiency Disease
Influence of Splenomegaly and Splenectomy on the Immune-Cell Profile of Patients with Common Variable Immunodeficiency Disease Open
Purpose About 25% of patients with common variable immunodeficiency disease (CVID) have splenomegaly necessitating splenectomy but its consequences on the immunological profile of CVID patients have never been studied. We analyzed 11 CVID …
View article: Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway Open
Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
View article: Data from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
Data from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway Open
Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is known to protect tumor cells from apoptosis and more specifically from the Fas-mediated apoptotic signal. The antitumoral agent edelfosine sensitizes leukemic cell…
View article: Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway Open
Supplementary Figures S1-S3 from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
View article: Data from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway
Data from Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway Open
Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is known to protect tumor cells from apoptosis and more specifically from the Fas-mediated apoptotic signal. The antitumoral agent edelfosine sensitizes leukemic cell…
View article: Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP Open
Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
View article: Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP Open
Supplementary Figures 1-2 from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
View article: Data from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
Data from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP Open
Fas triggering by agonistic antibodies or by its cognate ligand, FasL, induces apoptotic cell death, whereas mutation in the Fas death domain is associated with lymphoma progression. On prolonged culture in the presence of an agonistic ant…
View article: Data from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
Data from Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP Open
Fas triggering by agonistic antibodies or by its cognate ligand, FasL, induces apoptotic cell death, whereas mutation in the Fas death domain is associated with lymphoma progression. On prolonged culture in the presence of an agonistic ant…
View article: Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway Open
[This corrects the article DOI: 10.1371/journal.pbio.1001090.].
View article: Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states Open
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious di…
View article: COVID-19 EPIDEMIC IN THE NURSING HOMES IN BELGIUM
COVID-19 EPIDEMIC IN THE NURSING HOMES IN BELGIUM Open
The objective of this report is to describe the characteristics of the COVID-19 pandemic in nursing homes (NH) in Belgium, particularly in the Walloon (or French-speaking) part, and the local measures initiated to meet the urgent needs of …
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway Open
[This corrects the article DOI: 10.1371/journal.pbio.1001090.].
View article: Understanding Multicellularity: The Functional Organization of the Intercellular Space
Understanding Multicellularity: The Functional Organization of the Intercellular Space Open
The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology a…
View article: The Antigen-Presenting Potential of Vγ9Vδ2 T Cells During Plasmodium falciparum Blood-Stage Infection
The Antigen-Presenting Potential of Vγ9Vδ2 T Cells During Plasmodium falciparum Blood-Stage Infection Open
During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function, compromising effective antimalarial adaptive immunity. Human Vγ9Vδ2 T cells can act in vitro as antigen-presenting cells (…
View article: Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2
Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2 Open
Significance Human γδ T lymphocytes have innate-like and adaptive-like functions and can circulate in blood or reside in tissues. They are activated by specific antigens recognized by their T-cell receptor and recognize infected and transf…
View article: Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients
Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients Open
The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further in…
View article: Easier Control of Late-Onset Cytomegalovirus Disease Following Universal Prophylaxis Through an Early Antiviral Immune Response in Donor-Positive, Recipient-Negative Kidney Transplants
Easier Control of Late-Onset Cytomegalovirus Disease Following Universal Prophylaxis Through an Early Antiviral Immune Response in Donor-Positive, Recipient-Negative Kidney Transplants Open
Universal prophylaxis for cytomegalovirus (CMV) prevention is viable but, compared with a preemptive strategy, leads to higher incidence of late-onset disease (LOD) associated with poor patient and graft survival. The purpose of this study…
View article: Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells
Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells Open
Malaria induces potent activation and expansion of the Vγ9Vδ2 subpopulation of γδT cells, which inhibit the Plasmodium falciparum blood cycle through soluble cytotoxic mediators, abrogating merozoite invasion capacity. Intraerythrocytic st…
View article: Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants
Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants Open
Cytomegalovirus (CMV) infection in solid-organ transplantation is associated with increased morbidity and mortality, particularly if a CMV mutant strain with antiviral resistance emerges. Monitoring CMV-specific T cell response could provi…
View article: Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation
Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation Open
Anti‐HLA donor‐specific antibodies are deleterious for organ transplant survival. Class I HLA donor‐specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti‐denatured HLA antibodies…
View article: γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)
γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV) Open
Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved in the response to CMV but their role in protection has not been firmly established and their dependency on othe…
View article: TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance
TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance Open
Human γδ T cells contribute to tissue homeostasis under normal conditions and participate in lymphoid stress surveillance against infection and tumors. However, the molecular mechanisms underlying the recognition of complex cell stress sig…