Fabio Mosca
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View article: Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab)
Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab) Open
The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Sever…
View article: A Simplified, Regional Lung Ultrasound Score for Surfactant Administration in Neonatal RDS: A Prospective Observational Study
A Simplified, Regional Lung Ultrasound Score for Surfactant Administration in Neonatal RDS: A Prospective Observational Study Open
Background A total lung ultrasound score (tLUS) is a validated tool to describe parenchymal aeration, evaluate neonatal respiratory distress syndrome (RDS) progression and guide early surfactant replacement. tLUS derives from regional scor…
View article: Admission rate for bronchiolitis of newborns and infants in Italian neonatal intensive care units in 2021: a survey of the Italian Society of Neonatology - Intensive Care of Early Childhood Study Group
Admission rate for bronchiolitis of newborns and infants in Italian neonatal intensive care units in 2021: a survey of the Italian Society of Neonatology - Intensive Care of Early Childhood Study Group Open
Background The shortage of Pediatric Intensive Care Unit (PICU) beds among some Italian regions is a major concern, especially during epidemics. During respiratory syncytial virus (RSV) bronchiolitis peak, Neonatal Intensive Care Units (NI…
View article: Severity of respiratory syncytial virus through the COVID-19 pandemic among infants aged ≤2 months: a secondary analysis of the IRIDE cohort study
Severity of respiratory syncytial virus through the COVID-19 pandemic among infants aged ≤2 months: a secondary analysis of the IRIDE cohort study Open
Background Through the SARS-CoV-2 pandemic the severity of RSV infection increased among children, but little is known about its evolution among infants ≤60 days of life (DOL). Methods Multicenter observational retrospective study conducte…
View article: Rationale and study protocol of the MAMELI Cohort study (MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab)
Rationale and study protocol of the MAMELI Cohort study (MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab) Open
Background The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall he…
View article: Comparing Italian versus European strategies and technologies for respiratory care in NICU: results of a survey of the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN)
Comparing Italian versus European strategies and technologies for respiratory care in NICU: results of a survey of the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN) Open
Background Our survey aimed to compare information on respiratory care in Neonatal Intensive Care Units (NICUs) in Italy and in the European and Mediterranean region. Methods Cross-sectional electronic survey. An 89-item questionnaire focu…
View article: Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol
Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol Open
Background Up to 25–35% of women receive antibiotics (ABX) during pregnancy, but little is known about the consequences on a key mucosal interface such as the mammary gland, and on the development of the neonatal gut’s microbiota and IgA. …
View article: Viral Codetection and Clinical Outcomes of Infants Hospitalized With Bronchiolitis: A Multicenter Cohort Study
Viral Codetection and Clinical Outcomes of Infants Hospitalized With Bronchiolitis: A Multicenter Cohort Study Open
Background: The simultaneous identification of multiple respiratory viruses is common in infants hospitalized with respiratory tract infections. Respiratory syncytial virus (RSV) is one of the main pathogens in bronchiolitis, although code…
View article: Intimate Partner Violence (IPV) and Witnessing Domestic Violence (WDV): A Comparison of Italian and International Evidence
Intimate Partner Violence (IPV) and Witnessing Domestic Violence (WDV): A Comparison of Italian and International Evidence Open
The objective of this review is to examine the recent literature on Intimate Partner Violence (IPV) and Witnessing Domestic Violence (WDV) with a view to providing definitions, prevalence data for Italy and other countries, and for special…
View article: Clinical predictors for surfactant retreatment in preterm infants with respiratory distress syndrome: the results of a pooled analysis
Clinical predictors for surfactant retreatment in preterm infants with respiratory distress syndrome: the results of a pooled analysis Open
Background The issue of retreatment with surfactant of infants with respiratory distress syndrome (RDS) has been poorly investigated. Our aim was to identify possible clinical predictors of the need for multiple doses of surfactant in a la…
View article: Resuscitation With Placental Circulation Intact Compared With Cord Milking
Resuscitation With Placental Circulation Intact Compared With Cord Milking Open
Importance Among preterm newborns undergoing resuscitation, delayed cord clamping for 60 seconds is associated with reduced mortality compared with early clamping. However, the effects of longer durations of cord clamping with respiratory …
View article: The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries
The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries Open
Background An effective strategy to reduce perinatal mortality requires an active surveillance system. This includes monitoring cases, organizing multidisciplinary local audits, conducting Confidential Enquiries, identifying avoidable fact…
View article: LINE1 modulate human T cell function by regulating protein synthesis during the life span
LINE1 modulate human T cell function by regulating protein synthesis during the life span Open
The molecular mechanisms responsible for the heightened reactivity of quiescent T cells in human early life remain largely elusive. Our previous research identified that quiescent adult naïve CD4 + T cells express LINE1 (long interspersed …
View article: Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates
Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates Open
Importance A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improv…
View article: Biallelic NEXN variants and fetal onset dilated cardiomyopathy: two independent case reports and revision of literature
Biallelic NEXN variants and fetal onset dilated cardiomyopathy: two independent case reports and revision of literature Open
Background Dilated cardiomyopathy (DCM) is an etiologically heterogeneous group of diseases of the myocardium. With the rapid evolution in laboratory investigations, genetic background is increasingly determined including many genes with v…
View article: Why might cord blood be a better source of platelets for transfusion to neonates?
Why might cord blood be a better source of platelets for transfusion to neonates? Open
Thrombocytopenia (defined as a platelet count <150×109/L) is a common condition in preterm neonates and may occur in 18-35% of all infants admitted to the Neonatal Intensive Care Unit (NICU). Neonatal platelet functionality in terms of rea…
View article: Laryngeal Mask Airway in Neonatal Resuscitation: A Survey of the Union of European Neonatal and Perinatal Societies
Laryngeal Mask Airway in Neonatal Resuscitation: A Survey of the Union of European Neonatal and Perinatal Societies Open
Introduction: Laryngeal mask airway (LMA) use in neonatal resuscitation is limited despite existing evidence and recommendations. This survey investigated the knowledge and experience of healthcare providers on the use of the LMA and explo…
View article: Multidisciplinary follow-up in a patient with Morgagni hernia leads to diagnosis of Marfan syndrome
Multidisciplinary follow-up in a patient with Morgagni hernia leads to diagnosis of Marfan syndrome Open
Background congenital diaphragmatic hernia (CDH) is a birth defect occurring in isolated or syndromic (chromosomal or monogenic) conditions. The diaphragmatic defect can be the most common one: left-sided posterolateral, named Bochdalek he…
View article: Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN- REC-LISA trial)
Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN- REC-LISA trial) Open
Background: Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). Goals of different methods of surfactant administration are to reduce duration of mechanical ventilation and the sev…
View article: Clinical and economic burden of respiratory syncytial virus in children aged 0–5 years in Italy
Clinical and economic burden of respiratory syncytial virus in children aged 0–5 years in Italy Open
Background Respiratory syncytial virus (RSV) is among the leading causes of hospitalization due to lower respiratory tract infections (LRTIs) in children younger than 5 years worldwide and the second cause of infant death after malaria. RS…
View article: Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis
Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis Open
In physiological conditions, few circulating hematopoietic stem/progenitor cells (cHSPCs) are present in the peripheral blood, but their contribution to human hematopoiesis remain unsolved. By integrating advanced immunophenotyping, single…