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View article: Single and double faecal immunochemical test strategies are effective in risk stratification for patients with symptoms of per rectal bleeding suggestive of colorectal cancer
Single and double faecal immunochemical test strategies are effective in risk stratification for patients with symptoms of per rectal bleeding suggestive of colorectal cancer Open
Background Faecal immunochemical test (FIT) results triage urgent suspicion of colorectal cancer (USoC) referrals to investigation. As FIT detects microscopic blood, its role in patients with per rectal bleeding (PRB) is controversial. Pat…
View article: Clinical impact of double-faecal immunochemical testing following implementation into standard triage and investigation of primary care referrals in patients with lower gastrointestinal symptoms
Clinical impact of double-faecal immunochemical testing following implementation into standard triage and investigation of primary care referrals in patients with lower gastrointestinal symptoms Open
Background Faecal immunochemical testing has rapidly been established as the first-line triage for patients with symptoms suspicious for colorectal cancer. However, the reported low compliance of test returns issued from primary care is co…
View article: Risk factors and clinical consequences of interval cancers arising within faecal immunochemical testing-based colorectal cancer screening programme
Risk factors and clinical consequences of interval cancers arising within faecal immunochemical testing-based colorectal cancer screening programme Open
Background Colorectal cancer (CRC) screening programmes aim to detect early, asymptomatic cancers and improve survival. This study aimed to establish the proportion of interval cancers, and the consequences with regard to stage, clinical o…
View article: Accurate profiling of the gut microbiota using surplus clinical Faecal Immunochemical Test (FIT) samples
Accurate profiling of the gut microbiota using surplus clinical Faecal Immunochemical Test (FIT) samples Open
Background Numerous countries use the EXTEL HEMO-AUTO MC Quantitative Faecal Immunochemical Test (qFIT) to screen for faecal haemoglobin. We aimed to determine if bacterial 16S rRNA gene sequencing results (16S V1V2) from the leftover qFIT…
View article: Survival outcomes in patients with sigmoid volvulus
Survival outcomes in patients with sigmoid volvulus Open
Aim This study aimed to assess management pathways and outcomes in sigmoid volvulus (SV). Methods A retrospective review was performed on patients first admitted with SV between 2019 and 2023 within a tertiary-level colorectal service. Dem…
View article: Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence
Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence Open
Background Epigenetic changes contribute to colorectal cancer (CRC) pathogenesis. We investigated whether methylation quantitative trait loci (mQTLs) are associated with CRC risk, survival and recurrence. Methods Using a well-characterised…
View article: The Increased Early Onset Colorectal Cancer in South East Scotland Is Indicative of a Wider UK Problem
The Increased Early Onset Colorectal Cancer in South East Scotland Is Indicative of a Wider UK Problem Open
Worldwide, colorectal cancer (CRC) is the second most fatal cancer [...]
View article: Loss of colonic fidelity enables multilineage plasticity and metastasis
Loss of colonic fidelity enables multilineage plasticity and metastasis Open
Cancer cell plasticity enables the acquisition of new phenotypic features and is implicated as a major driver of metastatic progression 1,2 . Metastasis occurs mostly in the absence of additional genetic alterations 3–5 , which suggests th…
View article: Efficacy of different gingival graft de-epithelialization methods: A parallel-group randomized clinical trial
Efficacy of different gingival graft de-epithelialization methods: A parallel-group randomized clinical trial Open
Objectives The clinical outcomes of either extra-oral (eo) or intra-oral (io) de-epithelialized connective tissue graft (DE-CTG) techniques to the recipient site have not been fully elucidated yet. There is an ongoing debate regarding the …
View article: The significance of microscopically positive lymph node margins (<scp>R1</scp>) following surgical resection for Stage <scp>III</scp> colon cancer—A retrospective, observational study
The significance of microscopically positive lymph node margins (<span>R1</span>) following surgical resection for Stage <span>III</span> colon cancer—A retrospective, observational study Open
Aim Microscopically positive resection margins (R1) are associated with poorer outcomes in colon cancer. While the sequalae of a positive margin related to the primary tumour (R1Tumour) are relatively well known, comparatively less is know…
View article: Diagnostic Performance of Faecal Immunochemical Testing (FIT) in Patients with Lynch Syndrome Scheduled for Colonoscopic Surveillance
Diagnostic Performance of Faecal Immunochemical Testing (FIT) in Patients with Lynch Syndrome Scheduled for Colonoscopic Surveillance Open
Background and Aims: Lynch syndrome (LS) carries a substantial lifetime risk of colorectal cancer which is currently mitigated by biennial colonoscopy surveillance. Paramount to the surveillance programme is the removal of adenomas before …
View article: Repeat Faecal Immunochemical Testing for Colorectal Cancer Detection in Symptomatic and Screening Patients: A Systematic Review and Meta-Analysis
Repeat Faecal Immunochemical Testing for Colorectal Cancer Detection in Symptomatic and Screening Patients: A Systematic Review and Meta-Analysis Open
Background: Faecal immunochemical testing (FIT) is widely used in bowel screening programmes and assessing symptomatic patients for suspected colorectal cancer (CRC). The evidence for single test performance of FIT in both settings is cons…
View article: Treatment options for patients with pilonidal sinus disease: PITSTOP, a mixed-methods evaluation
Treatment options for patients with pilonidal sinus disease: PITSTOP, a mixed-methods evaluation Open
Background There is no consensus on optimal management of pilonidal disease. Surgical practice is varied, and existing literature is mainly single-centre cohort studies of varied disease severity, interventions and outcome assessments. Obj…
View article: Research and practice priorities in pilonidal sinus disease: a consensus from the <scp>PITSTOP</scp> study
Research and practice priorities in pilonidal sinus disease: a consensus from the <span>PITSTOP</span> study Open
Aim Pilonidal sinus disease is a common condition treated by colorectal surgeons. There is a lack of literature in the field to guide optimal management of this condition. As part of the PITSTOP study, we aimed to identify policy and resea…
View article: Classification and stratification in pilonidal sinus disease: findings from the <scp>PITSTOP</scp> cohort
Classification and stratification in pilonidal sinus disease: findings from the <span>PITSTOP</span> cohort Open
Aim Research in pilonidal disease faces several challenges, one of which is consistent and useful disease classification. The International Pilonidal Society (IPS) proposed a four‐part classification in 2017. The aim of this work was to as…
View article: Real-world practice and outcomes in pilonidal surgery: Pilonidal Sinus Treatment Studying The Options (PITSTOP) cohort
Real-world practice and outcomes in pilonidal surgery: Pilonidal Sinus Treatment Studying The Options (PITSTOP) cohort Open
Background Numerous surgical approaches exist for the treatment of pilonidal disease. Current literature on treatment is of poor quality, limiting the ability to define optimal intervention. The aim of this study was to provide real-world …
View article: Hereditary gastrointestinal polyposis syndromes Rare Disease Collaborative Network consensus statement agreed at the RDCN meeting Birmingham 17th February 2022
Hereditary gastrointestinal polyposis syndromes Rare Disease Collaborative Network consensus statement agreed at the RDCN meeting Birmingham 17th February 2022 Open
NHS England set out in the Implementation Plan for the UK Strategy for Rare Diseases (https://www.england.nhs.uk/wp-content/uploads/2018/01/implementation-plan-uk-strategy-for-rare-diseases.pdf) that it would develop and implement Rare Dis…
View article: Author response to: Comment on: Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer
Author response to: Comment on: Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer Open
View article: Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer
Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer Open
Background Faecal immunochemical test (FIT)-directed pathways based on a single test have been implemented for symptomatic patients. However, with a single test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) per g faeces. This a…
View article: Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico Open
View article: RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer Open
View article: Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation
Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation Open
Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which …
View article: Vitamin D treatment induces in vitro and ex vivo transcriptomic changes indicating anti‐tumor effects
Vitamin D treatment induces in vitro and ex vivo transcriptomic changes indicating anti‐tumor effects Open
Vitamin D deficiency is associated with risk of several common cancers, including colorectal cancer (CRC). Here we have utilized patient derived epithelial organoids (ex vivo) and CRC cell lines (in vitro) to show that calcitriol (1,25OHD)…
View article: Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects
Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects Open
Background The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determine whether oral vita…
View article: Risk of missing colorectal cancer with a COVID-adapted diagnostic pathway using quantitative faecal immunochemical testing
Risk of missing colorectal cancer with a COVID-adapted diagnostic pathway using quantitative faecal immunochemical testing Open
Background COVID-19 has brought an unprecedented challenge to healthcare services. The authors’ COVID-adapted pathway for suspected bowel cancer combines two quantitative faecal immunochemical tests (qFITs) with a standard CT scan with ora…
View article: RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways Open
View article: Short‐term outcomes of a COVID‐adapted triage pathway for colorectal cancer detection
Short‐term outcomes of a COVID‐adapted triage pathway for colorectal cancer detection Open
Aim The dramatic curtailment of endoscopy and CT colonography capacity during the coronavirus pandemic has adversely impacted timely diagnosis of colorectal cancer (CRC). We describe a rapidly implemented COVID‐adapted diagnostic pathway t…
View article: Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance
Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance Open
Previous studies using additive genetic models failed to identify robust evidence of associations between colorectal cancer (CRC) risk variants and survival outcomes. However, additive models can be prone to false negative detection if the…
View article: Implementation of a risk mitigating COVID-adapted colorectal cancer pathway
Implementation of a risk mitigating COVID-adapted colorectal cancer pathway Open
COVID-19 has brought about unprecedented challenges to healthcare systems forcing them to meet the sudden increase in demand of large numbers of critically ill patients. However, the long-term negative impact will be on patients without CO…
View article: Assessment of effectiveness of a COVID-adapted diagnostic pathway for colorectal cancer to mitigate the adverse impact on investigation and referrals
Assessment of effectiveness of a COVID-adapted diagnostic pathway for colorectal cancer to mitigate the adverse impact on investigation and referrals Open
Objectives The Coronavirus-19 (COVID-19) pandemic continues to impose formidable challenges on healthcare services. The dramatic curtailment of endoscopy and CT colonography capacity has adversely impacted on timely diagnosis of colorectal…