Françoise Guéraud
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View article: Bone morphogenetic protein signaling pathway: an essential role in intestinalhomeostasis and diseases
Bone morphogenetic protein signaling pathway: an essential role in intestinalhomeostasis and diseases Open
The bone morphogenetic protein (BMP) signaling pathway is a fundamental regulator of intestinal homeostasis, orchestrating the delicate balance between stem cell proliferation and epithelial differentiation along the crypt-villus axis. In …
View article: Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats
Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats Open
The bone morphogenetic protein (BMP) pathway, which plays a crucial role in the control of intestinal epithelial cell homeostasis, has been studied in mice and humans, leading to an understanding of its involvement in several intestinal pa…
View article: Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions
Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions Open
Graphical abstract Abstract Objective Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentrati…
View article: Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats
Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats Open
The haemoglobin content in meat is consistently associated with an increased risk of colorectal cancer, whereas calcium may play a role as a chemopreventive agent. Using rodent models, calcium salts have been shown to prevent the promotion…
View article: Spatial metabolomics using mass-spectrometry imaging to decipher the impact of high red meat diet on the colon metabolome in rat
Spatial metabolomics using mass-spectrometry imaging to decipher the impact of high red meat diet on the colon metabolome in rat Open
Colorectal cancer (CRC) is the third most common cancer in the world with a higher prevalence in the developed countries, mainly caused by environmental and lifestyle factors such as diet, particularly red meat consumption. The metabolic i…
View article: Epithelial-mesenchymal interaction protects normal colonocytes from 4-HNE-induced phenotypic transformation
Epithelial-mesenchymal interaction protects normal colonocytes from 4-HNE-induced phenotypic transformation Open
Introduction Recent studies have shown that epithelial-stromal interactions could play a role in the development of colorectal cancer. Here, we investigated the role of fibroblasts in the transformation of normal colonocytes induced by 4-H…
View article: Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats
Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats Open
Epidemiological and experimental evidence indicated that processed meat consumption is associated with colorectal cancer risks. Several studies suggest the involvement of nitrite or nitrate additives via N -nitroso-compound formation (NOCs…
View article: Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration
Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration Open
Summary Objective Increased consumption of meat is an epidemiologically validated risk condition for pancreatic cancer development, but the underlying mechanisms and whether it is related to induction of epithelial cell plasticity are unkn…
View article: Data from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption
Data from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption Open
Red meat is probably carcinogenic to humans (WHO/IARC class 2A), in part through heme iron-induced lipoperoxidation. Here, we investigated whether red meat promotes carcinogenesis in rodents and modulates associated biomarkers in volunteer…
View article: Supplementary documents from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption
Supplementary documents from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption Open
Supplementary figure, tables and results Supplementary Figure S1. Flowchart of the 6 studies Supplementary Table S1. Transitions and collision energies used for the quantification (Bold) and confirmation (Italic) of AAH on the triple quadr…
View article: Data from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption
Data from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption Open
Red meat is probably carcinogenic to humans (WHO/IARC class 2A), in part through heme iron-induced lipoperoxidation. Here, we investigated whether red meat promotes carcinogenesis in rodents and modulates associated biomarkers in volunteer…
View article: Supplementary documents from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption
Supplementary documents from Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption Open
Supplementary figure, tables and results Supplementary Figure S1. Flowchart of the 6 studies Supplementary Table S1. Transitions and collision energies used for the quantification (Bold) and confirmation (Italic) of AAH on the triple quadr…
View article: Data from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake
Data from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake Open
Epidemiology shows that red and processed meat intake is associated with an increased risk of colorectal cancer. Heme iron, heterocyclic amines, and endogenous N-nitroso compounds (NOC) are proposed to explain this effect, but their relati…
View article: Data from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake
Data from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake Open
Epidemiology shows that red and processed meat intake is associated with an increased risk of colorectal cancer. Heme iron, heterocyclic amines, and endogenous N-nitroso compounds (NOC) are proposed to explain this effect, but their relati…
View article: Supplementary Methods, Results and Figures 1 to 5 from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake
Supplementary Methods, Results and Figures 1 to 5 from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake Open
Supplementary Methods, Results, and Figures 1 to 5. Supplementary Figure 1: Flowchart of Bastide et al. Supplementary Figure 2. The consequences of the loss of Apc function in an intestinal cellular model derived from C57BL/6J mice. Supple…
View article: Supplementary Methods, Results and Figures 1 to 5 from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake
Supplementary Methods, Results and Figures 1 to 5 from A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake Open
Supplementary Methods, Results, and Figures 1 to 5. Supplementary Figure 1: Flowchart of Bastide et al. Supplementary Figure 2. The consequences of the loss of Apc function in an intestinal cellular model derived from C57BL/6J mice. Supple…
View article: Reduction, removal or replacement of sodium nitrite in a model of cured and cooked meat: a joint evaluation of consequences on microbiological issues in food safety, colon ecosystem and colorectal carcinogenesis
Reduction, removal or replacement of sodium nitrite in a model of cured and cooked meat: a joint evaluation of consequences on microbiological issues in food safety, colon ecosystem and colorectal carcinogenesis Open
Scope Epidemiological and experimental evidence reported that processed meat consumption is associated with colorectal cancer (CRC) risk. Several studies suggest the involvement of nitrite or nitrate additives via N -nitroso-compound forma…
View article: Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet‐Santé Cohort and an In Vivo Intervention Study in Rats
Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet‐Santé Cohort and an In Vivo Intervention Study in Rats Open
Scope High red and processed meat consumption is associated with several adverse outcomes such as colorectal cancer and overall global mortality. However, the underlying mechanisms remain debated and need to be elucidated. Methods and resu…
View article: Characterization of murine isogenic normal and NRF2-KO colon epithelial cells to explore the food contaminants toxicity and oxidative stress involvement.
Characterization of murine isogenic normal and NRF2-KO colon epithelial cells to explore the food contaminants toxicity and oxidative stress involvement. Open
Cell lines are a useful tool for cellular metabolism and xenobiotic toxicity studies, but for modeling biological effects of molecules on healthy cells or cancer promotion it appeared necessary to develop a cellular model in a normal genet…
View article: Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture
Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture Open
Continuous and rapid renewal of the colonic epithelium is crucial to resist the plethora of luminal deleterious agents. Subepithelial fibroblasts contribute to this turnover by regulating epithelial proliferation and differentiation. Howev…
View article: Towards Aldehydomics: Untargeted Trapping and Analysis of Reactive Diet-Related Carbonyl Compounds Formed in the Intestinal Lumen
Towards Aldehydomics: Untargeted Trapping and Analysis of Reactive Diet-Related Carbonyl Compounds Formed in the Intestinal Lumen Open
Lipid peroxidation and subsequent formation of toxic aldehydes, such as 4-hydroxynonenal, is known to be involved in numerous pathophysiological processes, possibly including the development of colorectal cancer. This work aimed at the dev…
View article: Regulation and Consumer Interest in an Antioxidant-Enriched Ham Associated with Reduced Colorectal Cancer Risks
Regulation and Consumer Interest in an Antioxidant-Enriched Ham Associated with Reduced Colorectal Cancer Risks Open
An economic experiment was conducted in France in 2020 to evaluate consumer attitudes toward two ham products associated with different colorectal cancer risks. We focused specifically on comparing a conventional ham and a new hypothetical…