Peter F. Orio
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View article: Long-term prostate cancer survival outcomes including patterns of death in men >=75 years of age treated with low dose rate brachytherapy
Long-term prostate cancer survival outcomes including patterns of death in men >=75 years of age treated with low dose rate brachytherapy Open
Definitive treatment is warranted in appropriately selected elderly men with clinically localized prostate cancer. Patient selection criteria to include the number of comorbidities must be assessed to maximize oncologic outcomes and minimi…
View article: Rectal Wall Infiltration After Stabilized Hyaluronic Acid Rectal Spacer Insertion in Prostate Cancer Radiation Therapy
Rectal Wall Infiltration After Stabilized Hyaluronic Acid Rectal Spacer Insertion in Prostate Cancer Radiation Therapy Open
Purpose: Rectal spacers, such as stabilized hyaluronic acid (sHA), are used to reduce rectal radiation dose and associated toxicities. Although they have a favorable safety profile, rectal wall infiltration (RWI) can occur. The aim of this…
View article: Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer
Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer Open
Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The ind…
View article: Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer
Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer Open
Background: Gleason score (GS) 10 prostate cancer (PC) is a highly aggressive localized disease. Despite advances in treating high-risk PC, the clinical outcomes and molecular underpinnings of GS 10 remain unclear. This study aimed to dete…
View article: Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices
Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices Open
Background Prostate cancer is a substantial health concern in the Middle East and North Africa region, with many cases diagnosed at advanced stages, a high mortality to incidence ratio, and low prostate cancer awareness. This study aimed t…
View article: Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer
Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer Open
Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic …
View article: Symmetry, separation, and stability: Physical properties for effective dosimetric space with a stabilized hyaluronic acid spacer
Symmetry, separation, and stability: Physical properties for effective dosimetric space with a stabilized hyaluronic acid spacer Open
Background The proximity of the rectum to the prostate in radiation therapy (RT) for prostate cancer presents a significant dosimetric challenge, leading to high rectal doses and resulting in detrimental side effects. Perirectal tissue spa…
View article: Prostate Cancer Awareness in the Middle East: A Cross-Sectional International Study
Prostate Cancer Awareness in the Middle East: A Cross-Sectional International Study Open
PURPOSE Prostate cancer has emerged as a significant public health challenge in the Middle East, characterized by rising incidence rates and a concerning mortality-to-incidence ratio. Yet, despite these alarming trends, data regarding pros…
View article: Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer
Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer Open
Purpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate can…
View article: Rectal Spacer Reduces Gastrointestinal Side Effects of Radiation Post Radical Prostatectomy
Rectal Spacer Reduces Gastrointestinal Side Effects of Radiation Post Radical Prostatectomy Open
Objectives: Our objective was to assess the rate of complications and gastrointestinal adverse effects of rectal spacer insertion for salvage post prostatectomy radiation therapy. Methods: A retrospective observational study was performed.…
View article: Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations
Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations Open
Purpose: Given the diverse clinical progression of prostate cancer (PC) and the evolving significance of histopathological factors in its management, this study aimed to explore the impact of cribriform pattern 4 (CP4) on clinical outcomes…
View article: Secondary analysis of late major gastrointestinal and genitourinary toxicities in unfavorable‐risk prostate cancer patients receiving docetaxel: Insights from a randomized trial
Secondary analysis of late major gastrointestinal and genitourinary toxicities in unfavorable‐risk prostate cancer patients receiving docetaxel: Insights from a randomized trial Open
Background This study sought to evaluate the late toxicity associated with neoadjuvant and concurrent docetaxel and radiation therapy in patients with prostate cancer. Methods A secondary analysis was performed of the phase 3 multicenter r…
View article: Prostate cancer presentation and management in the Middle East
Prostate cancer presentation and management in the Middle East Open
Background Although prostate cancer is a prevalent malignancy worldwide, its clinical presentation and management in the Middle East are not well-documented. This study aims to provide insights into the initial clinical presentation and ma…
View article: Evaluating the Quality-of-Life Effect of Apical Spacing with Hyaluronic Acid Prior to Hypofractionated Prostate Radiation Therapy: A Secondary Analysis
Evaluating the Quality-of-Life Effect of Apical Spacing with Hyaluronic Acid Prior to Hypofractionated Prostate Radiation Therapy: A Secondary Analysis Open
Greater apical spacing was associated with improved rectal dosimetry and smaller decline in bowel QOL at 3-months. Further prospective data are needed to fully understand the ramifications of increased apical spacing.
View article: Burden of prostate cancer in the Middle East: A comparative analysis based on global cancer observatory data
Burden of prostate cancer in the Middle East: A comparative analysis based on global cancer observatory data Open
Background Prostate cancer represents a significant global health issue, yet our understanding of its impact in the Middle East remains limited. This study aimed to assess the incidence and mortality of prostate cancer in the Middle East, …
View article: Risk of Short-Term Prostate-Specific Antigen Recurrence and Failure in Patients With Prostate Cancer
Risk of Short-Term Prostate-Specific Antigen Recurrence and Failure in Patients With Prostate Cancer Open
Importance A shorter time interval to prostate-specific antigen (PSA) failure is associated with worse clinical outcomes; however, specific factors defining this state remain unknown. Objective To evaluate the factors of a short time inter…
View article: Observer preference of artificial intelligence‐generated versus clinical prostate contours for ultrasound‐based high dose rate brachytherapy
Observer preference of artificial intelligence‐generated versus clinical prostate contours for ultrasound‐based high dose rate brachytherapy Open
Background For trans‐rectal ultrasound (TRUS)‐based high dose rate (HDR) prostate brachytherapy, prostate contouring can be challenging due to artifacts from implanted needles, bleeding, and calcifications. Purpose To evaluate the geometri…
View article: Barrigel Spacer Injection Technique
Barrigel Spacer Injection Technique Open
The combination of intensity modulated radiation therapy and image-guided radiation therapy has improved the ability to spare normal tissue during definitive radiation therapy for organ-confined prostate cancer, allowing dose escalation th…
View article: Radiation therapy for prostate cancer in Syrian refugees: facing the need for change
Radiation therapy for prostate cancer in Syrian refugees: facing the need for change Open
Purpose To report the utilization of radiation therapy in Syrian refugee patients with prostate cancer residing in Turkey. Methods and materials A multi-institutional retrospective review including 14 cancer centers in Turkey was conducted…
View article: Association Between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy
Association Between Artificial Intelligence-Derived Tumor Volume and Oncologic Outcomes for Localized Prostate Cancer Treated with Radiation Therapy Open
Background Although clinical features of multi-parametric magnetic resonance imaging (mpMRI) have been associated with biochemical recurrence in localized prostate cancer, such features are subject to inter-observer variability. Objective …
View article: Synthesizing and Applying Molecular Targeted Imaging Results in Patients With Prostate Cancer (RADAR VII)
Synthesizing and Applying Molecular Targeted Imaging Results in Patients With Prostate Cancer (RADAR VII) Open
Purpose: Molecular targeted imaging (MTI) is one of the most powerful new tools in the prostate cancer arsenal, but incorporation of MTI results into treatment decision making continues to be a challenge. Guidance is available for clinicia…
View article: Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy
Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy Open
Importance Hypofractionated radiation therapy (RT) for prostate cancer has been associated with greater acute grade 2 gastrointestinal (GI) toxic effects compared with conventionally fractionated RT. Objective To evaluate whether a hyaluro…