Francesca Pecori Giraldi
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View article: Correction: Unusual infections and thrombotic events in Cushing’s syndrome
Correction: Unusual infections and thrombotic events in Cushing’s syndrome Open
View article: Unusual infections and thrombotic events in Cushing’s syndrome
Unusual infections and thrombotic events in Cushing’s syndrome Open
The diagnosis of Cushing’s syndrome requires a high degree of suspicion, especially in patients in whom typical features are overshadowed by other ailments. These include, among others, widespread opportunistic infections or sepsis and ven…
View article: Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion
Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion Open
View article: High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery Open
Objective The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not dev…
View article: A novel somatostatin receptor ligand for human ACTH – and GH –secreting pituitary adenomas
A novel somatostatin receptor ligand for human ACTH – and GH –secreting pituitary adenomas Open
Objective Somatostatin receptor ligands have come to play a pivotal role in the treatment of both ACTH- and GH-secreting pituitary adenomas. Clinical efficacy averages 30-50%, thus a considerable number of patients with Cushing's disease o…
View article: Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome Open
Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUS…
View article: Silibinin, an HSP90 Inhibitor, on Human ACTH-Secreting Adenomas
Silibinin, an HSP90 Inhibitor, on Human ACTH-Secreting Adenomas Open
Introduction: The glucocorticoid receptor is pivotal to control corticotrophin (ACTH) secretion, and its function is closely linked to the heat shock protein 90 (HSP90) chaperone complex. Impaired sensitivity to glucocorticoid feedback is …
View article: Effects of cerebellar tDCS on glycometabolic control
Effects of cerebellar tDCS on glycometabolic control Open
View article: Obesity Is Strongly Associated With Low Testosterone and Reduced Penis Growth During Development
Obesity Is Strongly Associated With Low Testosterone and Reduced Penis Growth During Development Open
Context Growth of male genitalia represents an important marker of sexual development. Testicle size is the primary measure and little is known regards penile length changes during puberty. Objective This work aims to assess penis growth a…
View article: Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues Open
Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all- trans and 9- cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting …
View article: Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations
Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations Open
Background Corticotroph tumor progression (CTP) leading to Nelson’s syndrome (NS) is a severe and difficult-to-treat complication subsequent to bilateral adrenalectomy (BADX) for Cushing’s disease. Its characteristics are not well describe…
View article: Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome
Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome Open
View article: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome
Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome Open
Purpose The efficacy of levoketoconazole in treating hypercortisolism was demonstrated in an open-label phase 3 study (SONICS) of adults with endogenous Cushing’s syndrome (CS) and baseline mean urinary free cortisol (mUFC) ≥ 1.5× ULN. Cli…
View article: SAT-308 Effect of Silibinin on ACTH Synthesis and Secretion in Human Adenomatous Corticotropes in Vitro
SAT-308 Effect of Silibinin on ACTH Synthesis and Secretion in Human Adenomatous Corticotropes in Vitro Open
Silibinin, a milk thistle extract with known hepatoprotective effects, has recently been shown to act upon tumoral corticotropes and revert the Cushingoid phenotype in an allograft mouse model (Riebold et al 2015). Silbinin is known to inh…
View article: Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas
Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas Open
(1) Background. Cushing’s disease presents gender disparities in prevalence and clinical course. Little is known, however, about sexual dimorphism at the level of the corticotrope adenoma itself. The aim of the present study was to evaluat…
View article: High mortality within 90 days of diagnosis in patients with Cushing’s syndrome: results from the ERCUSYN registry
High mortality within 90 days of diagnosis in patients with Cushing’s syndrome: results from the ERCUSYN registry Open
Objective Patients with Cushing’s syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time of death in a large cohort of patients with CS and to establish factors associated with increased mortality…
View article: <b><i>Ubiquitin-Specific Protease 8</i></b> Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing
<b><i>Ubiquitin-Specific Protease 8</i></b> Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing Open
Background: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been shown to occur in ACTH-secreting pituitary adenomas, thus calling attention to the ubiquitin system in corticotrope adenomas. <…
View article: SAT-346 POR Rs2286822 Polymorphism Is Associated with Clinical Features in Patients with Congenital Adrenal Hyperplasia Due to 21 Hydroxylase Deficiency
SAT-346 POR Rs2286822 Polymorphism Is Associated with Clinical Features in Patients with Congenital Adrenal Hyperplasia Due to 21 Hydroxylase Deficiency Open
Patients with congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency present a strong genotype-phenotype correlation but variability in clinical features among patients carrying similar CYP21A2 mutations suggests that polyge…
View article: Gene expression profiling in human corticotroph tumours reveals distinct, neuroendocrine profiles
Gene expression profiling in human corticotroph tumours reveals distinct, neuroendocrine profiles Open
Adrenocorticotrophic hormone (ACTH)‐secreting pituitary adenomas give rise to a severe endocrinological disorder, comprising Cushing's disease, with multifaceted clinical presentation and treatment outcomes. Experimental studies suggest th…
View article: Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major
Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major Open
View article: Role of the ubiquitin/proteasome system on ACTH turnover in rat corticotropes
Role of the ubiquitin/proteasome system on ACTH turnover in rat corticotropes Open
We provide the first evidence that the ubiquitin-proteasome system is involved in proopiomelanocortin/ACTH degradation in corticotropes. Indeed, proopiomelanocortin is a target of ubiquitylation and modulation of ubiquitin-proteasome syste…
View article: Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN
Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN Open
Background Surgery is the definitive treatment of Cushing’s syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) affects postoperative outcome remains controversial. Objective…
View article: Usefulness of desmopressin testing to predict relapse during long-term follow-up in patients in remission from Cushing’s disease
Usefulness of desmopressin testing to predict relapse during long-term follow-up in patients in remission from Cushing’s disease Open
Recurrence of Cushing’s disease after successful transsphenoidal surgery occurs in some 30% of the patients and the response to desmopressin shortly after surgery has been proposed as a marker for disease recurrence. The aim of the present…
View article: Effects of environmental pollutants on signaling pathways in rat pituitary GH3 adenoma cells
Effects of environmental pollutants on signaling pathways in rat pituitary GH3 adenoma cells Open
View article: Risposte atipiche e paradossali al pasireotide in pazienti con tumori ipofisari aggressivi secernenti ACTH
Risposte atipiche e paradossali al pasireotide in pazienti con tumori ipofisari aggressivi secernenti ACTH Open
View article: Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study
Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study Open
Objective Evidence is limited regarding outcome of patients with ectopic Cushing’s syndrome (ECS) due to neuroendocrine tumors (NETs). Design We assessed the prognostic factors affecting the survival of patients with NETs and ECS. Methods …
View article: Benzene and 2-ethyl-phthalate induce proliferation in normal rat pituitary cells
Benzene and 2-ethyl-phthalate induce proliferation in normal rat pituitary cells Open
Our findings indicate that benzene and 2-ethyl-phthalate activate AhR/AIP expression and stimulate proliferation in normal rat pituitary cells. This study is the first demonstration that pollutants can induce normal pituitary cells to prol…
View article: Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas
Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas Open
ACTH-secreting pituitary tumors are by definition partially autonomous, i.e., secrete ACTH independent of physiological control. However, only few, small-sized studies on proopiomelanocortin (POMC) and its regulation by corticotropin-relea…
View article: Combined clinical and gene expression profiling in human ACTH-secreting pituitary tumors
Combined clinical and gene expression profiling in human ACTH-secreting pituitary tumors Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Effect of retinoic acid on human adrenal corticosteroid synthesis
Effect of retinoic acid on human adrenal corticosteroid synthesis Open