Fabiana Piscitelli
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View article: Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes
Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes Open
Mild traumatic brain injury (mTBI) represents a significant public health concern, often resulting in long-term cognitive, emotional, and behavioral impairments. Despite its prevalence, effective therapeutic strategies for mitigating mTBI …
View article: Astrocytes modulate neuronal development by S100A6 signaling
Astrocytes modulate neuronal development by S100A6 signaling Open
Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal conn…
View article: Combined CB1 antagonist AM6545 and NOP agonist SCH221510 worsen DSS-induced colitis in mice
Combined CB1 antagonist AM6545 and NOP agonist SCH221510 worsen DSS-induced colitis in mice Open
Our study offers novel insights into the interaction between the ECS and the NOP receptor, which may inform the development of new therapeutic strategies for inflammatory conditions such as colitis.
View article: Deciphering the interaction between N-palmitoyl-D-glucosamine and the endocannabinoidome
Deciphering the interaction between N-palmitoyl-D-glucosamine and the endocannabinoidome Open
N-palmitoyl-D-glucosamine (PGA) belongs to the class of molecules known as Autacoid Local Injury Antagonism (ALIA)-amides, whose parent compound is N-palmitoyl-ethanolamine (PEA) an endocannabinoid-like mediator belonging to the expanded e…
View article: Deficiency of the commensal Bacteroides vulgatus exacerbates skeletal muscle damage in mouse and human models of Duchenne Muscular Dystrophy
Deficiency of the commensal Bacteroides vulgatus exacerbates skeletal muscle damage in mouse and human models of Duchenne Muscular Dystrophy Open
Gut microbiota perturbations are increasingly implicated in skeletal muscle disorders. In this study, we analyzed fecal samples from mice and humans with Duchenne muscular dystrophy (DMD), a severe X-linked myopathy, and found significant …
View article: Anti-obesity effects of Oleoylethanolamide: Modulation of mitochondrial bioenergetics, endocannabinoidome and gut microbiome
Anti-obesity effects of Oleoylethanolamide: Modulation of mitochondrial bioenergetics, endocannabinoidome and gut microbiome Open
The endocannabinoidome (eCBome) and gut microbiome play key roles in metabolism and obesity, and oleoylethanolamide (OEA), a lipid mediator within the eCBome, is known to reduce food intake and promote fat oxidation. This study investigate…
View article: The emerging role of endocannabinoid system modulation in human fibroblast-like synoviocytes: Exploring new biomarkers and potential therapeutic targets
The emerging role of endocannabinoid system modulation in human fibroblast-like synoviocytes: Exploring new biomarkers and potential therapeutic targets Open
Human fibroblast-like synoviocytes (HFLS) are the predominant cellular component of the joint synovium. Their inflammation, known as synovitis, may contribute to the development of osteoarthritis (OA). HFLS secrete signaling factors that r…
View article: Enhanced visualization of endocannabinoids spatial distribution in mouse brain via MALDI-2 mass spectrometry imaging
Enhanced visualization of endocannabinoids spatial distribution in mouse brain via MALDI-2 mass spectrometry imaging Open
Endocannabinoids (eCBs) are endogenous lipid messengers that primarily bind cannabinoid receptors CB1/CB2 and together with the enzymes that regulate their biosynthesis and degradation define the endocannabinoid system. The eCB signaling s…
View article: Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations
Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations Open
Interest in preventative dietary interventions for human health has increasingly focused on the endocannabinoid (eCB)-like compound palmitoylethanolamide (PEA), a bioactive lipid mediator with anti-inflammatory, analgesic, and neuroprotect…
View article: Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats
Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats Open
Cannabidiol has been shown to ameliorate neuropathic pain and its affective components. Previous studies highlighted the pharmacological interaction between the CBD and opioid system, particularly the MOR, but the understanding of the inte…
View article: The Endocannabinoid Activity Remodulation for Psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Ultramicronized-Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis
The Endocannabinoid Activity Remodulation for Psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Ultramicronized-Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis Open
To date, no psychotropic medication has shown to effectively halt progression to psychosis among individuals at Clinical High-Risk for psychosis (CHR), fueling the search for novel therapeutic agents. Recent evidence supports Palmitoyletha…
View article: Assessing the biobehavioral effects of ultramicronized-palmitoylethanolamide monotherapy in autistic adults with different severity levels: a report of two cases
Assessing the biobehavioral effects of ultramicronized-palmitoylethanolamide monotherapy in autistic adults with different severity levels: a report of two cases Open
Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far. We discussed th…
View article: Circulating Endocannabinoids in Canine Cutaneous Mast Cell Tumor
Circulating Endocannabinoids in Canine Cutaneous Mast Cell Tumor Open
A cutaneous mast cell tumor (cMCT) is among the most common tumors in dogs. Endocannabinoids (eCBs) belong to the endocannabinoid system (ECS), which involves also cannabinoid receptors and an enzymatic system of biosynthesis and degradati…
View article: Vicia faba L. Pod Valves: A By-Product with High Potential as an Adjuvant in the Treatment of Parkinson’s Disease
Vicia faba L. Pod Valves: A By-Product with High Potential as an Adjuvant in the Treatment of Parkinson’s Disease Open
Vicia faba L. is a leguminous plant with seeds rich in nutritional compounds, such as polyphenols and L-dopa, a dopamine precursor and first-line treatment for Parkinson’s symptoms. Recently, its by-products have been revalued as a sustain…
View article: Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis
Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis Open
Background and purpose Preclinical studies of amyotrophic lateral sclerosis (ALS) have shown altered endocannabinoid (eCB) signalling that may contribute to the disease. Results from human studies are sparse and inconclusive. The aim of th…
View article: Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and <i>N</i>‐acylethanolamines in patients with hereditary angioedema due to <scp>FXII</scp> mutation
Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and <i>N</i>‐acylethanolamines in patients with hereditary angioedema due to <span>FXII</span> mutation Open
Background Hereditary angioedema (HAE) is a rare genetic disorder characterized by local, self‐limiting edema due to temporary increase in vascular permeability. HAE with normal C1 esterase inhibitor (C1INH) activity includes the form with…
View article: Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect
Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect Open
[This corrects the article DOI: 10.3389/fphar.2018.00249.].
View article: The Supplementation Therapy in Autism and Response to Treatment (START) Study: An Open-Label Feasibility Trial of Ultramicronized Palmitoylethanolamide Potential to Alleviate Psychic Distress among Autistic Adults
The Supplementation Therapy in Autism and Response to Treatment (START) Study: An Open-Label Feasibility Trial of Ultramicronized Palmitoylethanolamide Potential to Alleviate Psychic Distress among Autistic Adults Open
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication and restricted or repetitive behavior and interests. Psychic distress is common among individuals with ASD, especially …
View article: The Endocannabinoid Activity Remodulation for psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis
The Endocannabinoid Activity Remodulation for psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis Open
Background To date, no psychotropic medication has shown to effectively halt progression to psychosis among individuals at Clinical High-Risk for psychosis (CHR), fueling the search for novel therapeutic agents. Recent evidence supports Pa…
View article: Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis.
Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis. Open
Objectives Preclinical studies of amyotrophic lateral sclerosis (ALS) have shown altered endocannabinoid (eCB) signalling that may contribute to the disease. Results from human studies are sparse and inconclusive. The aim of this study was…
View article: Sleep loss impairs myelin function by altering cholesterol metabolism in oligodendroglia
Sleep loss impairs myelin function by altering cholesterol metabolism in oligodendroglia Open
The increasing prevalence of sleep deprivation in modern society demands comprehension of the biological consequences of sleep loss on brain functioning. Our study reveals significant effects of sleep deprivation on myelin integrity. As a …
View article: Astrocytes modulate neuronal development by S100A6 signaling
Astrocytes modulate neuronal development by S100A6 signaling Open
Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal conn…
View article: Questioning the role of palmitoylethanolamide in psychosis: a systematic review of clinical and preclinical evidence
Questioning the role of palmitoylethanolamide in psychosis: a systematic review of clinical and preclinical evidence Open
Introduction The endocannabinoid (eCB) system disruption has been suggested to underpin the development of psychosis, fueling the search for novel, better-tolerated antipsychotic agents that target the eCB system. Among these, palmitoyleth…
View article: Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice Open
Background Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in cognition, persona…