Frank A. Post
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View article: The Impact of Recipient HIV Status on Kidney Transplant Outcomes in the United Kingdom: Have Previous Studies Overestimated Risk?
The Impact of Recipient HIV Status on Kidney Transplant Outcomes in the United Kingdom: Have Previous Studies Overestimated Risk? Open
Background. Despite increasing literature on kidney transplantation in people with HIV, studies have largely overlooked the confounding impact of ethnicity and socioeconomic deprivation. This study aimed to assess posttransplant outcomes i…
View article: Intersecting social determinants of health, multimorbidity and quality of life in people of Black ethnicities with HIV in South London
Intersecting social determinants of health, multimorbidity and quality of life in people of Black ethnicities with HIV in South London Open
Background: Social determinants of health (SDoH) impact health outcomes and rarely exert their influence in isolation. We examined associations between SDoH patterns, multimorbidity and quality of life (QoL) in people of Black ethnicities …
View article: Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period
Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period Open
Background: Despite increasing multimorbidity among people with HIV, its impact on health outcomes over time remains uncertain. We explored how distinct multimorbidity patterns affect a broad range of health outcomes over a 3–5-year period…
View article: The impact of obesity on defibrillation threshold testing, shock effectiveness and inadequate shock rate in a bicentric cohort of S-ICD recipients
The impact of obesity on defibrillation threshold testing, shock effectiveness and inadequate shock rate in a bicentric cohort of S-ICD recipients Open
Background Sudden cardiac death (SCD) remains a leading cause of cardiovascular mortality. The implantation of a defibrillator (ICD) proved to significantly reduce mortality in well selected patients. To overcome typical complications asso…
View article: Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV
Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV Open
Objectives: There is no consensus definition for multimorbidity. We explored how different frameworks affect multimorbidity patterns and their associations with patient-reported outcomes using the prospective, observational Pharmacokinetic…
View article: Antiretroviral therapy in people with HIV and end-stage kidney disease
Antiretroviral therapy in people with HIV and end-stage kidney disease Open
Objective: To summarize antiretroviral therapy (ART) use in the setting of end-stage kidney disease (ESKD). Design: Cross-sectional analysis. Methods: Descriptive analysis of ART regimens and dose of nucleoside/nucleotide reverse-transcrip…
View article: Exploring the cascade of mental healthcare among people with <scp>HIV</scp> experiencing depressive symptoms in the UK and Ireland: The <scp>POPPY</scp> study
Exploring the cascade of mental healthcare among people with <span>HIV</span> experiencing depressive symptoms in the UK and Ireland: The <span>POPPY</span> study Open
Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People…
View article: Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV
Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV Open
Background: We aimed to provide insights into the effects of comorbidities on sleep health in people with HIV by assessing associations between multimorbidity patterns and sleep outcomes in the Pharmacokinetic and clinical Observations in …
View article: ‘COVID impacted my life in so many ways’: a qualitative study of the lived experiences of the COVID-19 pandemic among people of Black ethnicities living with HIV in England
‘COVID impacted my life in so many ways’: a qualitative study of the lived experiences of the COVID-19 pandemic among people of Black ethnicities living with HIV in England Open
Ethical approval was obtained from the University College London Research Ethics Committee (Project ID/Title: 6698/004).
View article: Brief Report: Cystatin C Provides Substantially Higher Glomerular Filtration Rate Estimates Than Creatinine in a Subset of Black People With HIV on Current Antiretroviral Regimens
Brief Report: Cystatin C Provides Substantially Higher Glomerular Filtration Rate Estimates Than Creatinine in a Subset of Black People With HIV on Current Antiretroviral Regimens Open
Background: In African populations, estimated glomerular filtration rate by cystatin C (eGFRcys) is better aligned with gold-standard GFR measurements than eGFR by creatinine (eGFRcr). Moreover, eGFRcys is unaffected by the effects of anti…
View article: Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection
Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection Open
Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear.…
View article: Epigenetic associations with kidney disease in individuals of African ancestry with <i>APOL1</i> high-risk genotypes and HIV
Epigenetic associations with kidney disease in individuals of African ancestry with <i>APOL1</i> high-risk genotypes and HIV Open
Background Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but n…
View article: Cardiovascular disease risk in people of African ancestry with <scp>HIV</scp> in the United Kingdom
Cardiovascular disease risk in people of African ancestry with <span>HIV</span> in the United Kingdom Open
Objectives Our objective was to describe the prevalence of cardiovascular disease (CVD) risk factors in people of African ancestry with HIV in the UK. Methods We conducted a cross‐sectional analysis of CVD risk factors in Black people with…
View article: MAVMET trial: maraviroc and/or metformin for metabolic dysfunction associated fatty liver disease in adults with suppressed HIV
MAVMET trial: maraviroc and/or metformin for metabolic dysfunction associated fatty liver disease in adults with suppressed HIV Open
Objective: Metabolic dysfunction associated fatty liver disease (MAFLD) is over-represented in people with HIV (PWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and fatty acid metabolism. D…
View article: Social determinants of health and long‐term conditions in people of Black African and Black Caribbean ethnicity living with HIV in London: A qualitative study
Social determinants of health and long‐term conditions in people of Black African and Black Caribbean ethnicity living with HIV in London: A qualitative study Open
Background People living with human immunodeficiency virus (HIV) are disproportionately impacted by socioeconomic deprivation and are at increased risk of developing other long‐term conditions (LTCs). These illnesses require transformative…
View article: HIV outcomes during the COVID‐19 pandemic in people of Black ethnicities living with HIV in England
HIV outcomes during the COVID‐19 pandemic in people of Black ethnicities living with HIV in England Open
Objectives To describe HIV care outcomes in people of Black ethnicities living in England during the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2; coronavirus disease 2019 [COVID‐19]) pandemic. Methods This was an observatio…
View article: Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study)
Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study) Open
Background There are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV. Methods Cross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver …
View article: Determinants of early change in serum creatinine after initiation of dolutegravir‐based antiretroviral therapy in South Africa
Determinants of early change in serum creatinine after initiation of dolutegravir‐based antiretroviral therapy in South Africa Open
Aims Dolutegravir increases serum creatinine by inhibiting its renal tubular secretion and elimination. We investigated determinants of early changes in serum creatinine in a southern African cohort starting first‐line dolutegravir‐based a…
View article: Associations between social determinants of health and comorbidity and multimorbidity in people of black ethnicities with HIV
Associations between social determinants of health and comorbidity and multimorbidity in people of black ethnicities with HIV Open
Objective: Social determinants of health (SDH) are important determinants of long-term conditions and multimorbidity in the general population. The intersecting relationship between SDH and multimorbidity in people with HIV remains poorly …
View article: Clinical epidemiology of <scp>COVID</scp>‐19 in people of black ethnicity living with <scp>HIV</scp> in the UK
Clinical epidemiology of <span>COVID</span>‐19 in people of black ethnicity living with <span>HIV</span> in the UK Open
Objectives To describe the clinical epidemiology of COVID‐19 in people of black ethnicity living with HIV in the UK. Methods We investigated the incidence and factors associated with COVID‐19 in a previously established and well‐characteri…
View article: Hepatic steatosis in people older and younger than fifty who are living with <scp>HIV</scp> and <scp>HIV</scp>‐negative controls: A cross‐sectional study nested within the <scp>POPPY</scp> cohort
Hepatic steatosis in people older and younger than fifty who are living with <span>HIV</span> and <span>HIV</span>‐negative controls: A cross‐sectional study nested within the <span>POPPY</span> cohort Open
Background Hepatic steatosis is a major cause of chronic liver disease associated with several negative health outcomes. We compared the prevalence of and factors associated with steatosis in people living with and without HIV. Methods Old…
View article: Anticholinergic medications associated with falls and frailty in people with <scp>HIV</scp>
Anticholinergic medications associated with falls and frailty in people with <span>HIV</span> Open
Background Anticholinergic medications (ACMs) are associated with poorer age‐related outcomes, including falls and frailty. We investigate associations between ACM use and recurrent falls and frailty among older (aged ≥50 years) people wit…
View article: Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans
Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans Open
Objective Renal toxicity is more common with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide fumarate (TAF). We investigated whether polymorphisms in genes relevant to tenofovir disposition affect renal toxicity among H…
View article: HbA1c screening for diabetes mellitus and to evaluate diabetic control in people of African ancestry with HIV in South London
HbA1c screening for diabetes mellitus and to evaluate diabetic control in people of African ancestry with HIV in South London Open
We evaluated glycaemic status in 948 Black adults with HIV and report a high prevalence of dysglycaemia (37.2%). HbA1c testing identified 38 (4.0%) individuals not previously known to have diabetes mellitus (DM) and showed suboptimal or po…
View article: Changes in multimorbidity burden over a 3–5 year period among people with HIV
Changes in multimorbidity burden over a 3–5 year period among people with HIV Open
Introduction: As people living with HIV age, the increasing burden of multimorbidity poses a significant health challenge. The aims of this study were to identify common patterns of multimorbidity and examine changes in their burden, as we…