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View article: ‘I just didn’t find time to exercise’: Co-designed physical activity resources for young Australian shiftworkers
‘I just didn’t find time to exercise’: Co-designed physical activity resources for young Australian shiftworkers Open
Shiftworkers are vital to essential industries yet often experience adverse health impacts, including barriers to regular physical activity. Young shiftworkers face additional challenges due to the transitional life stage and the increase …
View article: The genetic origin of fetal growth restriction and mitochondrial complex I dysregulation
The genetic origin of fetal growth restriction and mitochondrial complex I dysregulation Open
Background Mitochondria are organelles required for bioenergetic homeostasis, providing energy in the form of ATP to support cellular function, growth, and proliferation. Mitochondria synthesise ATP using the electron transport chain (ETC)…
View article: Placental Iron Utilisation in Fetal Growth Restriction: Alterations in Mitochondrial Heme Synthesis and Iron-Sulfur Cluster Assembly Pathways
Placental Iron Utilisation in Fetal Growth Restriction: Alterations in Mitochondrial Heme Synthesis and Iron-Sulfur Cluster Assembly Pathways Open
Fetal growth restriction (FGR) affects ∼10% of pregnancies worldwide and is often associated with placental insufficiency. Iron is essential for maternal haematopoietic adaptations and placental processes such as mitochondrial iron–sulfur …
View article: Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta
Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta Open
Summary Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture alter as cells differentiate remains unclear. The human placenta is an ideal model for studying mitochondrial diversit…
View article: Effects of Molybdenum Supplementation in the Form of Ammonium and Sodium Salts on Trophoblast Cell Physiology and Gene Expression In Vitro
Effects of Molybdenum Supplementation in the Form of Ammonium and Sodium Salts on Trophoblast Cell Physiology and Gene Expression In Vitro Open
Molybdenum is an essential trace element sourced during pregnancy from the maternal diet. Studies regarding molybdenum have primarily focused on overexposure in animal and cell culture studies. The effects of molybdenum supplementation on …
View article: ZTF SN Ia DR2: High-velocity components in the Si ii λ6355
ZTF SN Ia DR2: High-velocity components in the Si ii λ6355 Open
L. Harvey et al.
View article: Maternal mortality ratios in low- and middle-income countries: a comparison of estimation methods and relationships with sociodemographic covariates
Maternal mortality ratios in low- and middle-income countries: a comparison of estimation methods and relationships with sociodemographic covariates Open
Maternal mortality ratio estimates are reproducible using different estimation methods in low- and middle-income countries. Only 30% of the low- and middle-income countries for which serial data are available are projected to meet the Sust…
View article: SN 2019odp – A massive oxygen-rich Type Ib supernova
SN 2019odp – A massive oxygen-rich Type Ib supernova Open
Aims. Stripped envelope (SE) supernovae are explosions of stars that have somehow lost most of their outer envelopes. We present the discovery and analyse the observations of the Type Ib supernova 2019odp (a.k.a. ZTF19abqwtfu) covering epo…
View article: The Relationship between Maternal Smoking and Infant Birth Weight: Improving Accuracy through Urine Cotinine Analysis and Effective Medical Record Strategies
The Relationship between Maternal Smoking and Infant Birth Weight: Improving Accuracy through Urine Cotinine Analysis and Effective Medical Record Strategies Open
Objective: We conducted a study to determine if antenatally collected maternal urine cotinine (a metabolite of nicotine) measurements can be used to assess the neonatal impact of nicotine exposure during pregnancy. This was a prospective l…
View article: Placental Element Content Assessed via Synchrotron-Based X-ray Fluorescence Microscopy Identifies Low Molybdenum Concentrations in Foetal Growth Restriction, Postdate Delivery and Stillbirth
Placental Element Content Assessed via Synchrotron-Based X-ray Fluorescence Microscopy Identifies Low Molybdenum Concentrations in Foetal Growth Restriction, Postdate Delivery and Stillbirth Open
Placental health and foetal development are dependent upon element homeostasis. Analytical techniques such as mass spectroscopy can provide quantitative data on element concentrations in placental tissue but do not show spatial distributio…
View article: The longitudinal effects of neonatal anthropometry on attention problems in males and females
The longitudinal effects of neonatal anthropometry on attention problems in males and females Open
Background The longitudinal impact of fetal growth on attention problems in males and females is unclear. This study aims to evaluate the impact of fetal growth assessed by neonatal anthropometry throughout childhood and adolescence in mal…
View article: The Relationship between Maternal Smoking and Infant Birth Weight: Improving Accuracy through Urine Cotinine Analysis and Effective Medical Record Strategies
The Relationship between Maternal Smoking and Infant Birth Weight: Improving Accuracy through Urine Cotinine Analysis and Effective Medical Record Strategies Open
We conducted a study to determine if antenatally collected maternal urine cotinine (a me- 13 tabolite of nicotine) measurements can be used to assess the neonatal impact of nicotine exposure 14 during pregnancy. This was a prospective long…
View article: Prospective observational pilot study of the T2Resistance panel in the T2Dx system for detection of resistance genes in bacterial bloodstream infections
Prospective observational pilot study of the T2Resistance panel in the T2Dx system for detection of resistance genes in bacterial bloodstream infections Open
Early initiation of antimicrobial therapy targeting resistant bacterial pathogens causing sepsis and bloodstream infections (BSIs) is critical for a successful outcome. The T2Resistance Panel (T2R) detects the following resistance genes wi…
View article: Reducing maternal mortality in low- and middle-income countries: the Nepalese approach of helicopter retrieval
Reducing maternal mortality in low- and middle-income countries: the Nepalese approach of helicopter retrieval Open
Ninety-four percent of global maternal deaths occur in low- and middle-income countries (LMICs). The UN has a goal of reducing maternal deaths to <70 per 100,000 live births by 2030, but progress is minimal. Maternal deaths in LMICs are as…
View article: Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood
Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood Open
Placental corticotropin-releasing hormone (pCRH) is a neuroactive peptide produced in high concentrations in mid-late pregnancy, during key periods of fetal brain development. Some evidence suggests that higher pCRH exposure during gestati…
View article: 600. Rapid Detection of Antibiotic Resistance Genes Direct from Whole Blood Samples by T2 Magnetic Resonance (T2MR®)
600. Rapid Detection of Antibiotic Resistance Genes Direct from Whole Blood Samples by T2 Magnetic Resonance (T2MR®) Open
Background According to the Centers for Disease Control and Prevention (CDC), more than 2.8 million antibiotic-resistant infections occur in the US each year and more than 35,000 individuals die due to these infections. Rapid identificatio…
View article: Panic at the ISCO: time-varying double-peaked broad lines from evolving accretion disks are common amongst optically variable AGN
Panic at the ISCO: time-varying double-peaked broad lines from evolving accretion disks are common amongst optically variable AGN Open
About 3-10\% of Type I active galactic nuclei (AGN) have double-peaked broad Balmer lines in their optical spectra originating from the motion of gas in their accretion disk. Double-peaked profiles arise not only in AGN, but occasionally a…
View article: Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo
Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo Open
Metabolic inactivation of progesterone within uterine myocytes by 20α-hydroxysteroid dehydrogenase (20α-HSD) has been postulated as a mechanism contributing to functional progesterone withdrawal at term. In humans, 20α-HSD is encoded by th…
View article: Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health?
Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health? Open
Molybdenum is an essential trace element for human health and survival, with molybdenum-containing enzymes catalysing multiple reactions in the metabolism of purines, aldehydes, and sulfur-containing amino acids. Recommended daily intakes …
View article: Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol
Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol Open
Introduction Multiple cohort studies have been established to investigate the impact of early life factors on development and health outcomes. In Australia the majority of these studies were established more than 20 years ago and, although…
View article: Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders
Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders Open
In brief Placental oxidative stress contributes to both normal and abnormal placentation during pregnancy. This review discusses the potential consequence of oxidative stress-induced placental dysfunction on pregnancies complicated by feta…
View article: SN 2020udy: a SN Iax with strict limits on interaction consistent with a helium-star companion
SN 2020udy: a SN Iax with strict limits on interaction consistent with a helium-star companion Open
Early observations of transient explosions can provide vital clues to their progenitor origins. In this paper we present the nearby Type Iax (02cx-like) supernova (SN), SN 2020udy that was discovered within hours ($\sim$7 hr) of estimated …
View article: Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice
Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice Open
Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice
View article: Data from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice
Data from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice Open
Bioactive food components containing n-3 polyunsaturated fatty acids (PUFA) modulate multiple determinants that link inflammation to cancer initiation and progression. Therefore, in this study, fat-1 transgenic mice, which convert endogeno…
View article: Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice
Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in <i>Fat-1</i> (<i>n</i>-3 Fatty Acid Desaturase) Transgenic Mice Open
Supplementary Figures 1-2, Tables1-3 from Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice