Francesca Rosini
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View article: Lipidomic profiling of endometrial cancer using desorption electrospray ionization mass spectrometry imaging
Lipidomic profiling of endometrial cancer using desorption electrospray ionization mass spectrometry imaging Open
Novel technologies are required to improve endometrial cancer diagnosis and enhance the early detection of preinvasive precursors. Herein, desorption electrospray ionization mass spectrometry imaging (DESI-MSI) was used to differentiate ma…
View article: Serum neuronal, glial and mitochondrial markers in autosomal dominant optic atrophy and Leber hereditary optic neuropathy
Serum neuronal, glial and mitochondrial markers in autosomal dominant optic atrophy and Leber hereditary optic neuropathy Open
Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (ADOA) are the two most prevailing primary mitochondrial optic neuropathies. Both diseases preferentially affect the smallest retinal ganglion cells (GCs) of the…
View article: Gastric perineurioma: a rare entity with different clinical presentations. A case report
Gastric perineurioma: a rare entity with different clinical presentations. A case report Open
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View article: Is CMV DNAemia an early marker of CMV colitis in patients with active ulcerative colitis?
Is CMV DNAemia an early marker of CMV colitis in patients with active ulcerative colitis? Open
Cytomegalovirus (CMV) colitis is a serious concern worsening the prognosis of patients with ulcerative colitis (UC). We aimed to assess risk factors and prognostic impact of CMV colitis in patients with moderate-to-severe UC flare. We cond…
View article: Autosomal recessive cerebellar ataxias: a diagnostic classification approach according to ocular features
Autosomal recessive cerebellar ataxias: a diagnostic classification approach according to ocular features Open
Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of neurodegenerative disorders affecting primarily the cerebellum and/or its afferent tracts, often accompanied by damage of other neurological or extra-neurological …
View article: DOP03 Gaps between ECCO quality standards of care and the real world: the E-QUALITY survey on processes and outcomes
DOP03 Gaps between ECCO quality standards of care and the real world: the E-QUALITY survey on processes and outcomes Open
Background The European Crohn’s and Colitis Organisation (ECCO) Position Paper on Quality-of-Care (QoC) proposed essential standards on process and outcomes for units that manage patients with inflammatory bowel disease (IBD). The E-QUALIT…
View article: DOP01 Definitions of histological abnormalities in inflammatory bowel disease: an ECCO position paper
DOP01 Definitions of histological abnormalities in inflammatory bowel disease: an ECCO position paper Open
Background High quality histological examination of ileocolonic biopsies in inflammatory bowel disease (IBD) plays a critical role in optimising clinical management, investigative studies, and clinical trials. The correct assessment of his…
View article: Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper
Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper Open
Histological assessment of endoscopic biopsies in inflammatory bowel disease [IBD] plays an important role in clinical management, investigative studies, and clinical trials. Scoring schemes consisting of multiple histological items and of…
View article: Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma Open
The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical prac…
View article: Integrated clinicopathologic and molecular analysis of endometrial carcinoma: Prognostic impact of the new ESGO-ESTRO-ESP endometrial cancer risk classification and proposal of histopathologic algorithm for its implementation in clinical practice
Integrated clinicopathologic and molecular analysis of endometrial carcinoma: Prognostic impact of the new ESGO-ESTRO-ESP endometrial cancer risk classification and proposal of histopathologic algorithm for its implementation in clinical practice Open
Introduction The European Society of Gynecologic Oncology/European Society of Radiation Therapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) committee recently proposed a new risk stratification system for endometrial carcin…
View article: OP19 Gaps between ECCO quality standards of care and the real world: the E-QUALITY survey
OP19 Gaps between ECCO quality standards of care and the real world: the E-QUALITY survey Open
Background Recently, the European Crohn’s and Colitis Organisation (ECCO) Consensus on Quality-of-Care (QoC) Standards proposed essential criteria on the structure of units who manage patients with inflammatory bowel disease (IBD)1. The E-…
View article: Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)—A Prospective Pilot Study of Diagnostic Accuracy
Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)—A Prospective Pilot Study of Diagnostic Accuracy Open
Introduction: Delays in the diagnosis and treatment of endometrial cancer negatively impact patient survival. The aim of this study was to establish whether rapid evaporative ionisation mass spectrometry using the iKnife can accurately dis…
View article: Relevance of ARID1A Mutations in Endometrial Carcinomas
Relevance of ARID1A Mutations in Endometrial Carcinomas Open
Since the Cancer Genome Atlas (TCGA) project identified four distinct groups based on molecular alterations, mutation analyses have been integrated into the characterization of endometrial carcinomas (ECs). ARID1A seems to be the subunit m…
View article: Different saccadic profile in bulbar versus spinal-onset amyotrophic lateral sclerosis
Different saccadic profile in bulbar versus spinal-onset amyotrophic lateral sclerosis Open
Two clinical phenotypes characterize the onset of amyotrophic lateral sclerosis (ALS): the spinal variant, with symptoms beginning in the limbs, and the bulbar variant, affecting firstly speech and swallowing. The two variants show some di…
View article: ECCO Position on Harmonisation of Crohn’s Disease Mucosal Histopathology
ECCO Position on Harmonisation of Crohn’s Disease Mucosal Histopathology Open
In inflammatory bowel disease [IBD], mucosal healing is a major therapeutic target and a reliable predictor of clinical course. However, endoscopic mucosal healing is not synonymous with histological healing, and the additional benefits of…
View article: P-OGC39 The smell of oesophageal adenocarcinoma: opportunities for tests and treatments
P-OGC39 The smell of oesophageal adenocarcinoma: opportunities for tests and treatments Open
Background Exhaled breath analysis is a promising approach for oesophageal adenocarcinoma (OAC) early detection. The biomarkers of interest are low molecular weight metabolites including volatile aldehydes. In this translational study we i…
View article: What Is New on Ovarian Carcinoma: Integrated Morphologic and Molecular Analysis Following the New 2020 World Health Organization Classification of Female Genital Tumors
What Is New on Ovarian Carcinoma: Integrated Morphologic and Molecular Analysis Following the New 2020 World Health Organization Classification of Female Genital Tumors Open
Ovarian carcinomas represent a heterogeneous group of neoplasms consisting of separate entities with distinct risk factors, precursor lesions, pathogenesis, patterns of spread, molecular profiles, clinical course, response to chemotherapy,…
View article: Treatment of Advanced Gastro-Entero-Pancreatic Neuro-Endocrine Tumors: A Systematic Review and Network Meta-Analysis of Phase III Randomized Controlled Trials
Treatment of Advanced Gastro-Entero-Pancreatic Neuro-Endocrine Tumors: A Systematic Review and Network Meta-Analysis of Phase III Randomized Controlled Trials Open
Several new therapies have been approved to treat advanced gastro-entero-pancreatic neuroendocrine neoplasms (GEP–NENs) in the last twenty years. In this systematic review and meta-analysis, we searched MEDLINE, ISI Web of Science, and Sco…
View article: Neurophthalmologic and Orthoptic Ambulatory Assessments Reveal Ocular and Visual Changes in Patients With Early Alzheimer and Parkinson's Disease
Neurophthalmologic and Orthoptic Ambulatory Assessments Reveal Ocular and Visual Changes in Patients With Early Alzheimer and Parkinson's Disease Open
Patients with Alzheimer's disease (AD) and Parkinson's disease (PD) develop a progressive decline of visual function. This condition aggravates overall cognitive and motor abilities, is a risk factor for developing hallucinations, and can …
View article: ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology
ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology Open
Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about the additional advantages of including histological remission as a target. Accumulatin…
View article: The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease
The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease Open
Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also…
View article: A Cross-Recurrence Analysis of the Pupil Size Fluctuations in Steady Scotopic Conditions
A Cross-Recurrence Analysis of the Pupil Size Fluctuations in Steady Scotopic Conditions Open
Pupil size fluctuations during stationary scotopic conditions may convey information about the cortical state activity at rest. An important link between neuronal network state modulation and pupil fluctuations is the cholinergic and norad…