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View article: Influence of Biological Sex on Participant Characteristics, Guselkumab Efficacy and Radiographic Progression in Active Psoriatic Arthritis: Post Hoc Analysis of Three Randomized Trials
Influence of Biological Sex on Participant Characteristics, Guselkumab Efficacy and Radiographic Progression in Active Psoriatic Arthritis: Post Hoc Analysis of Three Randomized Trials Open
ClinicalTrials.gov identifier NCT03162796, NCT03158285, NCT03796858.
View article: Role of ultrasound in the prenatal diagnosis of sacrococcygeal teratoma: A case study
Role of ultrasound in the prenatal diagnosis of sacrococcygeal teratoma: A case study Open
Sacrococcygeal teratoma (SCT) is the most common congenital tumor arising from pluripotent cells at the fetal caudal end. Early prenatal diagnosis is essential for appropriate monitoring and management due to potential complications such a…
View article: Detection and Clinical Associations of Autoantibodies to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A2/B1 in Patients with Systemic Sclerosis
Detection and Clinical Associations of Autoantibodies to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A2/B1 in Patients with Systemic Sclerosis Open
Autoantibodies targeting heterogeneous nuclear ribonucleoproteins (hnRNPs) have been seldom described in autoimmune diseases but remain poorly characterized in systemic sclerosis (SSc). This study aims to investigate the prevalence and cli…
View article: Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort
Correlation between serum ANCA and cancer: a decade-long retrospective analysis of an Italian cohort Open
Background Serum antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies primarily linked with ANCA-associated vasculitides (AAV) but associated diseases include also other autoimmune diseases, infections, and malignancies. However…
View article: HLA-B27 as a potential target for the cure of axial spondyloarthritis
HLA-B27 as a potential target for the cure of axial spondyloarthritis Open
Axial spondyloarthritis (axSpA) manifests with inflammatory back pain and is diagnosed predominantly in subjects carrying the human leucocyte antigen (HLA)-B27 allele. While not diagnostic for the disease or a predictive biomarker in the g…
View article: First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry Open
Introduction Primary heart involvement (pHI) is an overlooked and poorly characterised complication of systemic sclerosis (SSc), associated with the risk of heart failure, arrhythmia and death. Despite consensus definition by the World Scl…
View article: Guselkumab and Il-17 Inhibitors Improve Patient-Perceived Impact of Psoriatic Arthritis Similarly: 6 Month Interim Results of the PsABIOnd Observational Cohort Study
Guselkumab and Il-17 Inhibitors Improve Patient-Perceived Impact of Psoriatic Arthritis Similarly: 6 Month Interim Results of the PsABIOnd Observational Cohort Study Open
Objectives Targeted drugs in PsA have demonstrated efficacy in randomized controlled trials, including aspects of patient-reported impact. However, comparison data from observational studies are scarce, particularly for IL-23 and IL-17 inh…
View article: 29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial
29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial Open
Background Biomarkers based on host response signatures are currently under development for the critically ill. We applied a 29-mRNA classifier for the diagnosis and prognosis of suspected acute infection and sepsis (TriVerity ™ , Inflamma…
View article: Ultrasound features of fetal toxoplasmosis : diagnostic and prognostic contributions in prenatal management
Ultrasound features of fetal toxoplasmosis : diagnostic and prognostic contributions in prenatal management Open
Background: Congenital toxoplasmosis (CT) is a parasitic infection that can cause severe fetal damage, particularly when maternal infection occurs early in pregnancy. Although biological methods remain the cornerstone of prenatal diagnosis…
View article: nowledge and behavior of Tunisian men regarding the couple’s contraception. Clinical trial
nowledge and behavior of Tunisian men regarding the couple’s contraception. Clinical trial Open
Objective: To assess the knowledge and the circumstances and sources from which men in Tunisia gain knowledge about contraception and their subsequent perceptions of different contraceptive methods. Methods: A cross-sectional study conduct…
View article: Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study
Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study Open
Objectives This study assessed how changes in lung function, skin fibrosis and digital ulceration (DU) burden predict mortality in patients with SSc-associated interstitial lung disease (SSc-ILD), the leading cause of death in SSc. Methods…
View article: Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance
Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance Open
The immune response to SARS-CoV-2 has been implicated in the onset of multiple, seemingly unrelated, autoimmune diseases. The immune response to SARS-CoV-2 has also been implicated in the unmasking and/or production of multiple autoantibod…
View article: Cancer in connective tissue disease
Cancer in connective tissue disease Open
The association between cancer and autoimmunity is well-recognized, as represented by the increased incidence of cancer among patients with systemic autoimmune diseases; however, the underlying mechanisms remain only partially understood. …
View article: E090 Guselkumab and IL-17 inhibitors improve patient-perceived impact of psoriatic arthritis similarly: 6-month interim results of the PsABIOnd observational cohort study
E090 Guselkumab and IL-17 inhibitors improve patient-perceived impact of psoriatic arthritis similarly: 6-month interim results of the PsABIOnd observational cohort study Open
Background/Aims PsA leads to significant patient-perceived burden of disease. Targeted drugs have demonstrated efficacy in randomised controlled trials including patient-reported impact. However, comparison data from observational studies …
View article: Environmental factors and rheumatic diseases
Environmental factors and rheumatic diseases Open
The pathogenesis and pathophysiology of rheumatic diseases is complex and relies on the interaction of different factors. The common view is that the pathological autoimmunity develops in genetically predisposed individuals upon exposure t…
View article: Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender
Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender Open
High disease activity, baseline erosions and disease duration are significantly associated with the D2T phenotype of RA while we confirm the importance of obesity and fibromyalgia.
View article: Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort
Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort Open
The significantly higher likelihood of developing enthesitis in IBD-first suggests that distinct disease onset patterns and clinical phenotypes may influence musculoskeletal manifestations and treatment responses in enteropathic arthritis.
View article: Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis
Serum IL-23 levels reflect a myeloid inflammatory signature and predict the response to apremilast in patients with psoriatic arthritis Open
Background The phosphodiesterase 4 (PDE4) inhibitor apremilast downregulates the production of IL-23 and other pro-inflammatory cytokines involved in the pathogenesis of psoriatic arthritis (PsA). Aim To investigate the effects of apremila…