Paul F. G. Sims YOU? Author Swipe

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CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant <i>Staphylococcus aureus</i> pulmonary host defense Open

Flávia Rago, Md. Sagir Ahmed, Michael A. Marinelli, Leigh M. Miller, Alexis M. Duray , et al. · 2025

Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as…

Feasibility of HPV self-sampling pathway in Kathmandu Valley, Nepal using a human-centred design approach Open

Swastika Shrestha, Saki Thapa, Paul F. G. Sims, Andreea Ardelean, Anamika Basu , et al. · 2021

Cervical cancer is preventable and curable yet causes almost 2000 deaths in Nepali women each year. The present study aims to explore the feasibility and acceptability of a self-sampling-based approach for cervical cancer screening in urba…

Effect of IAPP on the proteome of cultured Rin-5F cells Open

Samaneh Miraee-Nedjad, Paul F. G. Sims, Jean‐Marc Schwartz, Andrew J. Doig · 2018

Results are consistent with a model where IAPP aggregates overwhelm the ability of a cell to degrade proteins via the ubiquitin system. Ultimately this leads to apoptosis. IAPP aggregates may be also toxic to the cell by causing oxidative …

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions Open

David Talavera, Christopher J. Kershaw, Joseph L. Costello, Lydia M. Castelli, William Rowe , et al. · 2018

The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis gene…

Additional file 4: of Effect of IAPP on the proteome of cultured Rin-5F cells Open

Samaneh Miraee-Nedjad, Paul F. G. Sims, Jean‐Marc Schwartz, Andrew J. Doig · 2018

Table S3. Protein-Protein Interactions. (XLSX 44 kb)

Additional file 2: of Effect of IAPP on the proteome of cultured Rin-5F cells Open

Samaneh Miraee-Nedjad, Paul F. G. Sims, Jean‐Marc Schwartz, Andrew J. Doig · 2018

Table S1. Protein Mass Spectrometry Data. (ZIP 2439 kb)

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses Open

Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2017

Additional file 3: of Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses Open

Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2017

Supplementary Source Data 2. ∆T edgeR files for changes in transcript levels with stress. Each TAP-tagged strain ± each stress is shown in a different tab. edgeR outputs shown for Total stress/Total control (∆T). (XLSX 4301 kb)

Additional file 1: of Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses Open

Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2017

Supplementary Source Data 1. Counts by gene after analysis of mapped counts by HTSEQ. Transcript counts of mapped reads for each replicate of each experiment. (XLSX 2793Â kb)

Additional file 4: of Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses Open

Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2017

Supplementary Source Data 3. IP/T edgeR files for enrichment of RNAs in TAP IP with stress. Each TAP-tagged strain IP/T for stressed and unstressed samples is shown in a different tab. edgeR outputs shown for IP/Total (IP/T). (XLSX 5767Â k…

Additional file 5: of Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses Open

Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2017

Supplementary Source Data 4. ∆IP edgeR files for changes in IP with stress. Each TAP-tagged strain ± each stress is shown in a different tab. edgeR outputs shown for [IP(stress)/Total(stress)]/[IP(control)/Total(control)] (termed ∆IP). (XL…

Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring Open

Craig Lawless, Stephen W. Holman, Philip Brownridge, Karin Lanthaler, Victoria M. Harman , et al. · 2016

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p Open

Christopher J. Kershaw, Joseph L. Costello, David Talavera, William Rowe, Lydia M. Castelli , et al. · 2015

The PUF family of RNA-binding proteins regulate gene expression post-transcriptionally. Saccharomyces cerevisiae Puf3p is characterised as binding nuclear-encoded mRNAs specifying mitochondrial proteins. Extensive studies of its regulation…

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation Open

Lydia M. Castelli, David Talavera, Christopher J. Kershaw, Sarah S. Mohammad‐Qureshi, Joseph L. Costello , et al. · 2015

Translation initiation factor eIF4E mediates mRNA selection for protein synthesis via the mRNA 5'cap. A family of binding proteins, termed the 4E-BPs, interact with eIF4E to hinder ribosome recruitment. Mechanisms underlying mRNA specifici…

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response Open

Christopher J. Kershaw, Joseph L. Costello, Lydia M. Castelli, David Talavera, William Rowe , et al. · 2015

The mechanisms by which RNA-binding proteins control the translation of subsets of mRNAs are not yet clear. Slf1p and Sro9p are atypical-La motif containing proteins which are members of a superfamily of RNA-binding proteins conserved in e…

Global mRNA selection mechanisms for translation initiation Open

Joseph L. Costello, Lydia M. Castelli, William Rowe, Christopher J. Kershaw, David Talavera , et al. · 2015

Background The selection and regulation of individual mRNAs for translation initiation from a competing pool of mRNA are poorly understood processes. The closed loop complex, comprising eIF4E, eIF4G and PABP, and its regulation by 4E-BPs a…

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