Farida Sohrabji
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View article: Therapeutic effects of estrogens on inflammatory demyelination in a mouse model of multiple sclerosis
Therapeutic effects of estrogens on inflammatory demyelination in a mouse model of multiple sclerosis Open
View article: Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring
Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring Open
Background Prenatal alcohol exposure (PAE) is the major cause of developmental disability, ultimately resulting in a wide range of long‐term health consequences across the lifespan. PAE adults are at increased risk for metabolic, immune, a…
View article: Sex differences in neurological disorders: Insights from ischemic stroke, Parkinson’s disease, and multiple sclerosis
Sex differences in neurological disorders: Insights from ischemic stroke, Parkinson’s disease, and multiple sclerosis Open
Ischemic stroke, Parkinson's disease (PD), and multiple sclerosis (MS), are neurodegenerative disorders that exhibit significant sex differences in pathophysiology, clinical manifestations, and outcomes. Women are more likely to experience…
View article: Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells
Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells Open
Traumatic brain injury (TBI) occurs in 2-3 million Americans each year and is a leading cause of death and disability. Among the many physiological consequences of TBI, the hypothalamic pituitary axis (HPA) is particularly vulnerable, incl…
View article: Loss of white matter tracts and persistent microglial activation in the chronic phase of ischemic stroke in female rats and the effect of miR-20a-3p treatment
Loss of white matter tracts and persistent microglial activation in the chronic phase of ischemic stroke in female rats and the effect of miR-20a-3p treatment Open
Our previous studies showed that intravenous injections of the small non-coding RNA mir-20a-3p is neuroprotective for stroke in the acute phase and attenuates long-term cognitive impairment in middle-aged female rats. In this study, we eva…
View article: Therapeutic Effects of Estrogens on Inflammatory Demyelination in a Mouse Model of Multiple Sclerosis
Therapeutic Effects of Estrogens on Inflammatory Demyelination in a Mouse Model of Multiple Sclerosis Open
View article: Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis
Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis Open
Background Our studies show that the small non‐coding RNA, mir20a‐3p, is neuroprotective for stroke in the acute phase and also attenuates long term cognitive decline in middle‐aged female rats. Cognitive decline due to vascular diseases, …
View article: Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis
Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis Open
Background Our studies show that the small non‐coding RNA, mir20a‐3p, is neuroprotective for stroke in the acute phase and also attenuates long term cognitive decline in middle‐aged female rats. Cognitive decline due to vascular diseases, …
View article: Astrocytic glutamate transport is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice
Astrocytic glutamate transport is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice Open
Infusion of 17β-estradiol (E2) into the dorsal hippocampus (DH) of ovariectomized (OVX) mice enhances memory consolidation, an effect that depends on rapid phosphorylation of extracellular signal-regulated kinase (ERK) and Akt. …
View article: Peripheral, but not central, IGF-1 treatment attenuates stroke-induced cognitive impairment in middle-aged female Sprague Dawley rats: The gut as a therapeutic target
Peripheral, but not central, IGF-1 treatment attenuates stroke-induced cognitive impairment in middle-aged female Sprague Dawley rats: The gut as a therapeutic target Open
View article: Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke
Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke Open
View article: The aging ovary impairs acute stroke outcomes
The aging ovary impairs acute stroke outcomes Open
View article: Stroke Literature Synopses (Preclinical)
Stroke Literature Synopses (Preclinical) Open
View article: Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment Open
Stroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injectio…
View article: April <i>Stroke</i> Literature Synopses (Preclinical)
April <i>Stroke</i> Literature Synopses (Preclinical) Open
View article: Abstract Number ‐ 25: Acute Ischemic Stroke Intervention With Penumbra RED Reperfusion Catheters: Updated Subset Analysis From INSIGHT Registry
Abstract Number ‐ 25: Acute Ischemic Stroke Intervention With Penumbra RED Reperfusion Catheters: Updated Subset Analysis From INSIGHT Registry Open
Introduction The prospective INSIGHT Registry is a multicenter ‘multi‐omic’ analysis of thrombi associated with acute hemorrhagic or ischemic stroke. This updated interim analysis evaluated the performance of Penumbra RED catheters used du…
View article: February Literature Synopses
February Literature Synopses Open
lood-brain barrier (BBB) dysfunction, an early and major event in ischemic stroke, is characterized by structural and functional deficits of microvascular endothelial cells and is also associated with poor prognosis.Recently, preclinical a…
View article: Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke
Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke Open
Almost 2/3rds of stroke survivors exhibit vascular cognitive impairment and a third of stroke patients will develop dementia 1-3 years after stroke. These dire consequences underscore the need for effective stroke therapies. In …
View article: Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long‐term behavioral recovery from the effects of an adult‐onset cerebrovascular ischemic stroke
Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long‐term behavioral recovery from the effects of an adult‐onset cerebrovascular ischemic stroke Open
Background Prenatal alcohol exposure (PAE) is a significant risk factor for developmental disability, although its health consequences across the lifespan are poorly understood. Here, we hypothesized that latent brain and systemic conseque…
View article: <i>Stroke</i> Literature Synopsis (Preclinical)
<i>Stroke</i> Literature Synopsis (Preclinical) Open
View article: August Literature Synopsis
August Literature Synopsis Open
View article: Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age
Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age Open
Shift work is associated with increased risk for vascular disease, including stroke- and cardiovascular-related mortality. However, evidence from these studies is inadequate to distinguish the effect of altered circadian rhythms in isolati…
View article: June Literature Synopsis
June Literature Synopsis Open
View article: Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats
Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats Open
Endothelial dysfunction occurs earlier in males, but in females, dysfunction delays until middle age. GPER activation improves the vascular activities in females, but not males. It is promising to employ GPER as a potential drug target in …
View article: Correction to: Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats
Correction to: Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats Open
View article: Abstract 1122‐000211: Histology Profiles of Thrombi in Men and Women Undergoing Thrombectomy
Abstract 1122‐000211: Histology Profiles of Thrombi in Men and Women Undergoing Thrombectomy Open
This meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf
View article: Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant Open
MicroRNAs have gained popularity as a potential treatment for many diseases, including stroke. This study identifies and characterizes a specific member of the miR-17–92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensiv…
View article: Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats
Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats Open
Prenatal alcohol exposure (PAE) can result in neurobehavioral anomalies, that may be exacerbated by co-occurring metabolic and immune system deficits. To test the hypothesis that the peripheral inflammation in adult PAE offspring is linked…
View article: New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases Open
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients …
View article: Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats
Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats Open