Explanipedia

Specific Role of T and Tn Tumor‐associated Antigens in Adhesion between a Human Breast Carcinoma Cell Line and a Normal Human Breast Epithelial Cell Line Open

Teruko Kishikawa, Mohammad Ghazizadeh, Yoshihiro Sasaki, Georg F. Springer · 1999

Biology Medicine

The possibility that tumor‐associated antigens T and Tn act as adhesion molecules between normal and malignant breast epithelial cells at the early stages of recognition in the metastatic pathway was examined in vitro . The adhesive specif…

Quantitative Computerized Image Analysis of Tn and T (Thomsen–Friedenreich) Epitopes in Prognostication of Human Breast Carcinoma Open

Bao-Le Wang, Georg F. Springer, S.C. Carlstedt · 1997

Biology Medicine

The precursors of the blood group N and M-immunodominant structures, Tn and T (Thomsen–Friedenreich) epitopes (EPs) occur in ∼90% of carcinomas (CAs) but are masked in benign-diseased and healthy tissues. We determined quantitatively on 55…

Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells Open

Cynthia Timlick Aller, Ömer Küçük, Georg F. Springer, Alice Gilman‐Sachs · 1996

Medicine

Immunophenotyping of peripheral blood lymphocytes from six patients with B-cell chronic lymphocytic leukemia (B-CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cyt…

Concurrent immunohistochemical staining of tumor-infiltrating lymphocytes and carcinoma-associated T (Thomsen-Friedenreich)/Tn antigens in human breast carcinoma. Open

B L Wang, Georg F. Springer, Michael W. Kaufman · 1996

Biology Medicine

The composition of tumor-infiltrating lymphocytes (TIL) often reflects the host's immune response to the tumor. To study the relationship of TIL and carcinoma-associated T/Tn antigens in breast carcinoma, a straightforward concurrent immun…

Expression of thomsen-friedenreich-related antigens in primary and metastatic colorectal carcinomas. A reevaluation Open

Yi Cao, Uwe Karsten, Winfrid Liebrich, Wolfgang Haensch, Georg F. Springer , et al. · 1995

Medicine

These results prove unequivocally the presence of exposed TF epitopes in a majority of colorectal carcinomas in which both anomers of TF are expressed. These data further suggest that TF favors liver metastasis and that its expression in p…

In Memoriam: Dr. Enrique Pimentel Open

Roberto Patarca, J. V. Klavins, G. D. Birkmayer, Henry T. Lynch, Avery A. Sandberg , et al. · 1995

Philosophy Medicine

It is with deep sadness that we inform the readers of Critical Reviews in Oncogenesis of the untimely demise of Dr. Enrique Pimentel, founding editor of this journal.Dr. Pimentel has been an example and inspiration to all of us.The modest-…

Are pancarcinoma T and Tn differentiation antigens? Open

Nancy J. Barr, Clive R. Taylor, Terrance Young, Georg F. Springer · 1989

Biology Medicine

Human fetal tissues were studied for presence of immunoreactive Thomsen-Friedenreich (T) and Tn epitopes (EPs) using well-defined anti-T and anti-Tn rodent monoclonal antibodies. T and Tn are universal (pan) carcinoma (CA) markers that are…

Proposed molecular basis of murine tumor cell-hepatocyte interaction. Open

Georg F. Springer, R. Cheingsong‐Popov, Volker Schirrmacher, P. R. Desai, H. Tegtmeyer · 1983

Chemistry Biology

Buffered Saline was composed of 0.1 M aqueous NaCl plus 0.

Extent of desialation of blood group MM, NN, and MN antigens required for reactivity with human anti-T antibody and Arachis hypogaea lectin. Open

Georg F. Springer, P. R. Desai · 1982

Biology Chemistry Medicine

Immunochemical activity of the Arachis hypogaea lectin has been equated, in spite of its different hapten combining requirements, with that of the human anti-T (Thomsen-Friedenreich) antibody population which is of importance in cancer imm…

Endotoxin-binding substances from human leukocytes and platelets Open

Georg F. Springer, J. C. Adye · 1975

Biology

We have found whole human platelets, granulocytes, and mononuclear leukocytes to possess high affinity for the toxic lipopolysaccharide from all gram-negative bacteria tested. We have extracted these cells and platelets with n-butanol-wate…

Research and Development in Progress: Biomedical and Environmental Research Program Open

J. N. Stannard, Robert C. Baxter, J.E. Byfield, C.T. Gaffey, Alan H. Haber , et al. · 1972

Engineering Computer science

The ultimate goal of the Biological, Medical, and Environmental Research Program is to provide a body of scientific information which can be used to evaluate the possible hazardous effects of nuclear developments on man and his environment…

PREVENTION OF INTERACTIONS BETWEEN ERYTHROCYTE SURFACE STRUCTURES AND BLOOD- GROUP RELATED TOXIC SUBSTANCES OF MICROBES. Final Progress Report. Open

Georg F. Springer · 1972

Chemistry Biology Psychology

a new method of rotary shadow freeze-etching has been evaluated. The role of lipid-lipid and protein-protein interactions in controlling the mobility of cell surface macromolecules has been studied using freeze-fracture, protein extraction…

THE RELATIONSHIP OF THE INFLUENZA VIRUS INHIBITORY ACTIVITY OF GLYCOPROTEINS TO THEIR MOLECULAR SIZE AND SIALIC ACID CONTENT Open

Georg F. Springer, H. G. Schwick, Mary A Fletcher · 1969

Chemistry Biology

Twenty-four different glycoproteins were investigated for their ability to inhibit hemagglutination by the A/PRS and the B/Md influenza virus strains. A relationship between activity, the molecular size, and sialic acid content was found. …

Blood group isoantibody stimulation in man by feeding blood group-active bacteria Open

Georg F. Springer, Richard E. Horton · 1969

Biology Medicine

It was investigated whether or not the human blood group isoantibodies A and B could be induced by immunogenic stimuli via natural routes with a kind of antigenic substance to which all humans are commonly exposed, or if the appearance of …

Erythrocyte Sensitization by Blood Group-Specific Bacterial Antigens Open

Georg F. Springer, Richard E. Horton · 1964

Biology Chemistry

Human and chicken erythrocytes are readily coated in vitro by blood group active protein-lipopolysaccharides and lipopolysaccharides from E. coli O86 and E. coli O128. Serum albumin, α2- and ß-lipoproteins inhibit this sensitization. Blood…

BLOOD GROUP ACTIVITY OF GRAM-NEGATIVE BACTERIA Open

Georg F. Springer, Peter Williamson, William Brandes · 1961

Biology Medicine

Distribution of blood group A, B, and H(O) activities among 282 aerobic Gram-negative bacteria, many isolated from the blood of patients, has been studied. Almost half of these bacteria were found to be blood group active. About 10 per cen…

ORIGIN OF ANTI-HUMAN BLOOD GROUP B AGGLUTININS IN WHITE LEGHORN CHICKS Open

Georg F. Springer, Richard E. Horton, Martin Forbes · 1959

Biology Medicine

While anti-human blood group B agglutinins are present in the majority of ordinary White Leghorn chicks by the age of 30 days, none could be demonstrated in germfree chicks up to the age of 60 days. Anti-B agglutinins in trace amounts were…

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